Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Suzie Ferreira"'
Autor:
Suzie Ferreira do Nascimento
Publikováno v:
Revista Trágica, Vol 9, Iss 3 (2019)
Quando de suas primeiras reflexões sobre os gregos, Nietzsche concluiu que o aspecto formal das esculturas pré-helênicas revelava desejo de eternidade ou “otimismo”. Nesse artigo irei aproximar essas reflexões ao estilo que ficou conhecido en
Externí odkaz:
https://doaj.org/article/13a08cc7b7a5439f8fc9e861b913afb0
Autor:
Suzie Ferreira do Nascimento
Publikováno v:
ModaPalavra e-periódico, Vol 7, Iss 13 (2014)
Com este texto o que pretendemos é discutir, com vistas ao fazer design, se há pressupostos ao ato de criação e se é legítima a aproximação entre o criador de moda e os criadores das demais artes. Para tal, fizemos alusão especificamente ao
Externí odkaz:
https://doaj.org/article/677cc29ecc6e4923ada1f8319b2edb89
Autor:
Suzie Ferreira do Nascimento
Publikováno v:
ModaPalavra e-periódico, Vol 2, Iss 3 (2009)
Poucos pensadores têm se dedicado à reflexão sobre o fenômeno moda. O presente texto se propõe a exemplificar a possibilidade do exercício filosófico também nesse âmbito, testificando, assim, sua relevância. Reproduzindo, inicialmente, os a
Externí odkaz:
https://doaj.org/article/1dafb970cbfd4b4ba7ee095c38422bbf
Autor:
Rostam Namdari, Jianmin Fu, Brian K. Hubbard, Kuldip Khakh, Suzie Ferreira, Michael D. Winther, Zaihui Zhang, Vandna Raina, Duanjie Hou, Natalie Dales, David G. McLaren, Leslie G. Ratkay, Pokrovskaia Natalia, Shaoyi Sun, Monica Mork
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:526-531
We discovered a series of novel and potent thiazolylpyridinone-based SCD1 inhibitors based on a 2-aminothiazole HTS hit by replacing the amide bond with a pyridinone moiety. Compound 19 demonstrated good potency against SCD1 in vitro and in vivo. The
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(8)
The effectiveness of controlled release 1-aminobenzotriazole (ABT) administration to inhibit cytochrome P450 (P450) enzymes has been evaluated in mice. To maximize the duration of P450 inhibition in vivo, ABT was administered via an osmotic pump. The
Autor:
Chad A. Van Huis, Wendy Collard, Cuiman Cai, Michelle Mastronardi, Roxane Collins, Michael J. Ryan, Jeremy J. Edmunds, Erli Zhang, Mehran Jalaie, Chungang Gu, Ken Mennen, John W. Bryant, Patrick I. McConnell, Fred L. Ciske, Suzie Ferreira, Jacqueline E. Day, Daniel D. Holsworth, Noel A. Powell, Igor Mochalkin
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5912-5949
We report the design and synthesis of a series of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as orally bioavailable small molecule inhibitors of renin. Compounds with a 2-methyl-2-aryl substitution pattern exhibit potent renin inhibition and go
Autor:
Jakal Amin, Scott Louis Cohen, Brad Snodgrass, Xiao-Hui Chen, Monish Jain, Panos Hatsis, Suzie Ferreira, David Barnes-Seeman, Leslie Bell
Publikováno v:
ACS Medicinal Chemistry Letters. 4:514-516
Susceptibility to metabolism is a common issue with the tert-butyl group on compounds of medicinal interest. We demonstrate an approach of removing all the fully sp(3) C-Hs from a tert-butyl group: replacing some C-Hs with C-Fs and increasing the s-c
Autor:
Kenji Namoto, François Gessier, Garry Fenton, Mandy Beswick, Finton Sirockin, Alokesh Duttaroy, Suzie Ferreira, Ulrich Hassiepen, Stefanie Flohr, Bernd Gerhartz, Jörg Trappe, Jon Sutton, Nils Ostermann, David E. Clark, Daniel K. Baeschlin, Richard Sedrani
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(3)
The successful launches of dipeptidyl peptidase IV (DPP IV) inhibitors as oral anti-diabetics warrant and spur the further quest for additional chemical entities in this promising class of therapeutics. Numerous pharmaceutical companies have pursued
Autor:
Suzie Ferreira, Vinayak Hosagrahara, Upendra A. Argikar, Mithat Gunduz, Daniel K. Baeschlin, Shawn Harriman
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 38(3)
1-[4-Aminomethyl-4-(3-chlorophenyl)-cyclohexyl]-tetrahydro-pyrimidin- 2-one, 1, was developed as an inhibitor of dipeptidyl peptidase-4 enzyme. Biotransformation studies with 1 revealed the presence of an N-carbamoyl glucuronide metabolite (M1) in ra
Autor:
Jeremy J. Edmunds, Suzie Ferreira, Mehran Jalaie, Rajendra Subedi, Daniel D. Holsworth, Erli Zhang, Samarendra N. Maiti, Patrick I. McConnell, John W. Bryant, Tingsheng Li, Noel A. Powell, Thomas Richard Belliotti, Cuiman Cai, Michael J. Ryan, Igor Mochalkin, Michael Stier, Aparna Kasani, Wendy Collard
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(13)
Novel 2,4-diaminopyrimidine-based small molecule renin inhibitors are disclosed. Through high throughput screening, parallel synthesis, X-ray crystallography, and structure based drug design, we have developed the first non-chiral, non-peptidic, smal