Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Suzie, Yeh"'
Autor:
Kerry L. Fillgrove, Deanne Jackson Rudd, Eric Woolf, Melanie Anderson, Rena Zhang, Bing Lu, Suzie Yeh, Cynthia Chavez-Eng, Sheila Breidinger, Li Sun, Iris Xie
Publikováno v:
Bioanalysis. 11:233-250
Aim: MK-8591 (EFdA), a novel anti-HIV nucleoside analog, is converted to mono-, di- and tri-phosphates (MK-8591-MP, MK-8591-DP and MK-8591-TP) intracellularly, among which MK-8591-TP is the active pharmacological form. An ultrasensitive LC–MS/MS as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e44f02a4f38638ea284bda033f3b74
https://doi.org/10.4155/bio-2018-0101
https://doi.org/10.4155/bio-2018-0101
Autor:
Carrie Wolffe, Mark E. Fraley, Alexander Mccampbell, Rebecca B. White, Rena Zhang, John Majercak, Mary J. Savage, William J. Ray, Sang Jin Na, George D. Hartman, Shaei Y. Huang, Timothy J. Hartingh, Antonella Converso, Robert M. Garbaccio, Yuanjiang Yu, Suzie Yeh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2737-2740
Elevated plasma homocysteine (Hcy) levels are an independent risk factor for the onset and progression of Alzheimer's disease. Reduction of Hcy to normal levels therefore presents a new approach for disease modification. Hcy is produced by the cytoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8aa1f4f564027151b5c9e0f8c1f0175
https://doi.org/10.1016/j.bmcl.2014.04.034
https://doi.org/10.1016/j.bmcl.2014.04.034
Autor:
Edward Keough, Suzie Yeh, Mike Lyman, Ken Koeplinger, Ed Carlini, Charles D. Thompson, Jeff Roberts, Marian E. Gindy, Melissa Stern, Scott Fauty, Mei Ou, Yan Xu, Elizabeth Mahan, Conrad E. Raab, Yi Wang, Jerome Hochman, Rena Zhang, Don Slaughter
Publikováno v:
Molecular Pharmaceutics. 11:1424-1434
Effective delivery of small interfering RNA (siRNA) requires efficient cellular uptake and release into cytosol where it forms an active complex with RNAi induced silencing complex (RISC). Despite rapid developments in RNAi therapeutics, improvements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9336458e9196c53535274f85ff505c96
https://doi.org/10.1021/mp400584h
https://doi.org/10.1021/mp400584h
Autor:
Matthew J. Cato, Peter J. Manley, Christopher J. Dinsmore, Jixin Wang, B. Wesley Trotter, M. Brad Nolt, Bing Li, Robert H. Spencer, Mark T. Bilodeau, Gary L. Stump, Scott E. Wolkenberg, Rebecca B. White, Kausik K. Nanda, Laszlo Kiss, George D. Hartman, Craig W. Lindsley, Christopher P. Regan, Stefanie A. Kane, Zhicai Wu, Suzie Yeh, Joseph J. Lynch, Nathan R. Kett
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(4)
Selective inhibition of Kv1.5, which underlies the ultra-rapid delayed rectifier current, IKur, has been pursued as a treatment for atrial fibrillation. Here we describe the discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity versus the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28d78944ff68aea790d3850958003ea
https://pubmed.ncbi.nlm.nih.gov/28131713
https://pubmed.ncbi.nlm.nih.gov/28131713
Autor:
Jack Henion, Daniel Eikel, Carol Bason, Marissa Vavrek, Walter A. Korfmacher, Suzie Yeh, Sheri Smith
Publikováno v:
Rapid Communications in Mass Spectrometry. 25:3587-3596
Liquid extraction surface analysis mass spectrometry (LESA-MS) is a novel surface profiling technique that combines micro-liquid extraction from a solid surface with nano-electrospray mass spectrometry. One potential application is the examination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb6991413b5cc843d1acb0ddc35f34e2
https://doi.org/10.1002/rcm.5274
https://doi.org/10.1002/rcm.5274
Autor:
Michael D. Leitl, Darrell A. Henze, B. Wesley Trotter, Kimberly Della Penna, Ahren Iver Green, Mark T. Bilodeau, Zhicai Wu, Christopher S. Burgey, Wei Lemaire, Stefanie A. Kane, Craig M. Potteiger, Reshma Desai, Mark O. Urban, Suzie Yeh, Rebecca B. White, Nathan R. Kett, James Z. Deng, George D. Hartman, John C. Hartnett, Kausik K. Nanda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2354-2358
A new series of imidazopyridine CB2 agonists is described. Structural optimization improved CB2/CB1 selectivity in this series and conferred physical properties that facilitated high in vivo exposure, both centrally and peripherally. Administration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14244f428a1317fe2d743c1692b389db
https://doi.org/10.1016/j.bmcl.2011.02.082
https://doi.org/10.1016/j.bmcl.2011.02.082
Autor:
Suzie Yeh, John Majercak, Dawn Toolan, Alexei A. Podtelezhnikov, Peter Szczerba, Keith Wessner, Mary J. Savage, Keith Q. Tanis, Carrie Wolffe, Michael W. Marlatt, Alexander McCampbell, William J. Ray, Rena Zhang
Publikováno v:
Journal of Neurochemistry. 116:82-92
Elevated plasma homocysteine, a risk factor for Alzheimer's disease, could result from increased production from methionine or by inefficient clearance by folate- and B-vitamin-dependent pathways. Understanding the relative contributions of these pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f3046176b1643bc925365beffc26c5b
https://doi.org/10.1111/j.1471-4159.2010.07087.x
https://doi.org/10.1111/j.1471-4159.2010.07087.x
Autor:
Nigel J. Liverton, Douglas C. Beshore, Robert H. Spencer, Brian E. Libby, Charles J. Mcintyre, Stephanie A. Kane, Laszlo Kiss, Christopher P. Regan, Christopher J. Dinsmore, Joseph J. Salata, J. Christopher Culberson, Christopher F. Claiborne, George D. Hartman, Rebecca B. White, Joseph J. Lynch, Suzie Yeh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2493-2496
A series of triarylethanolamine inhibitors of the Kv1.5 potassium channel have been prepared and evaluated for their effects in vitro and in vivo. The structure–activity relationship (SAR) studies described herein led to the development of potent,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a05fe6bb599aa540b83e8c246924240
https://doi.org/10.1016/j.bmcl.2010.03.005
https://doi.org/10.1016/j.bmcl.2010.03.005
Autor:
Darrell A. Henze, Mark T. Bilodeau, Kausik K. Nanda, Wei Lemaire, Kimberly Della Penna, Suzie Yeh, B. Wesley Trotter, Janine N. Brouillette, George D. Hartman, Michael D. Leitl, Reshma Desai, Rebecca B. White
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(4)
A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf50a82eeebf4c0853e663a39f8d1e02
https://pubmed.ncbi.nlm.nih.gov/24461289
https://pubmed.ncbi.nlm.nih.gov/24461289
Autor:
Daniel, Eikel, Marissa, Vavrek, Sheri, Smith, Carol, Bason, Suzie, Yeh, Walter A, Korfmacher, Jack D, Henion
Publikováno v:
Rapid communications in mass spectrometry : RCM. 25(23)
Liquid extraction surface analysis mass spectrometry (LESA-MS) is a novel surface profiling technique that combines micro-liquid extraction from a solid surface with nano-electrospray mass spectrometry. One potential application is the examination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::325687401608920baf4b18ed02780651
https://pubmed.ncbi.nlm.nih.gov/22095508
https://pubmed.ncbi.nlm.nih.gov/22095508