Zobrazeno 1 - 10 of 45 pro vyhledávání: '"Suzette R. Riddle"'
1
Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model
Autor: R. Dale Brown, Kendall S. Hunter, Min Li, Maria G. Frid, Julie Harral, Greta M. Krafsur, Timothy N. Holt, Jason Williams, Hui Zhang, Suzette R. Riddle, Michael G. Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B. Graham, Lori A. Walker, Franklyn B. Garry, Peter M. Buttrick, Tim Lahm, Vitaly O. Kheyfets, Kirk C. Hansen, Kurt R. Stenmark
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 324:H804-H820
Using a large animal model and employing a comprehensive approach integrating hemodynamic, transcriptomic, proteomic, and immunohistochemical analyses, we examined the early (2 wk) effects of severe PH on the RV. We observed that RV remodeling during
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e426dd05eb030a8846d9667ad5f8d584
https://doi.org/10.1152/ajpheart.00614.2022
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2
Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages
Autor: Hui Zhang, Angelo D'Alessandro, Kirk C. Hansen, Subhash Chandra Yadav, Sushil Kumar, Min Li, Monika Dzieciatkowska, Micaela K Roy, Maria G. Frid, Kurt R. Stenmark, R. Dale Brown, Suzette R. Riddle
Publikováno v: JCI Insight
Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by complement-dependent, fibroblast-induced perivascular accumulation and proinflammatory activation of macrophages. We hypothesized that, in PH, nanoscale-sized small extr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175ece36b248e14e21b6e3b3f054b60a
https://doi.org/10.1172/jci.insight.148382
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3
Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension
Autor: Maria G. Frid, Kurt R. Stenmark, Aya Laux, Karim C. El Kasmi, Sushil Kumar, Suzette R. Riddle, Joanna M. Poczobutt, Julie A. Reisz, B. Alexandre McKeon, R. Dale Brown, Maureen J. Ostaff, Min Li, Mehdi A. Fini, Angelo D'Alessandro, Travis Nemkov, Hui Zhang, Cheng-Jun Hu
Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
The recruitment and subsequent polarization of inflammatory monocytes/macrophages in the perivascular regions of pulmonary arteries is a key feature of pulmonary hypertension (PH). However, the mechanisms driving macrophage polarization within the ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966286f45b365e8bfccc582a2d524c9c
https://pubmed.ncbi.nlm.nih.gov/33868271
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7
Suppression of HIF2 signaling attenuates the initiation of hypoxia-induced pulmonary hypertension
Autor: Maria G. Frid, Steven C. Pugliese, Aya Laux, Amanda Flockton, Min Li, Sushil Kumar, R. Dale Brown, Kurt R. Stenmark, Suzette R. Riddle, Brittany McKeon, Wallace Eli M, Gary Mouradian, Brian B. Graham, Jens M. Poth, Hui Zhang, Cheng-Jun Hu
Most published studies addressing the role of HIFs in hypoxia-induced PH development employ models that may not recapitulate the clinical setting, including the use of animals having pre-existing lung/vascular defects secondary to embryonic HIF ablat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414f6c5c8b519a08599cc8ecce1e6e89
https://europepmc.org/articles/PMC6911916/
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8
A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension
Autor: Sushil Kumar, William J. Janssen, Suzette R. Riddle, Kurt R. Stenmark, Brian B. Graham, Maria G. Frid, Steven C. Pugliese, Karim C. El Kasmi
Publikováno v: The Journal of Immunology. 198:4802-4812
Studies in various animal models suggest an important role for pulmonary macrophages in the pathogenesis of pulmonary hypertension (PH). Yet, the molecular mechanisms characterizing the functional macrophage phenotype relative to time and pulmonary l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9c1882b530416a63f0a96129ff4ff65
https://doi.org/10.4049/jimmunol.1601692
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