ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels

Autor: Jeremiah Bernier-Latmani, Cristina Mauri, Rachel Marcone, François Renevey, Stephan Durot, Liqun He, Michael Vanlandewijck, Catherine Maclachlan, Suzel Davanture, Nicola Zamboni, Graham W. Knott, Sanjiv A. Luther, Christer Betsholtz, Mauro Delorenzi, Cathrin Brisken, Tatiana V. Petrova

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

The molecular mechanisms ensuring the specialized structure of small intestinal villus tip blood vessels are incompletely understood. Here the authors show that ADAMTS18+ telocytes maintain a “just-right” level and location of VEGFA signaling on

Externí odkaz: https://doaj.org/article/4f38232a5b4a4d508652a6e98af1cc5f

ADAMTS18

Autor: Jeremiah, Bernier-Latmani, Cristina, Mauri, Rachel, Marcone, François, Renevey, Stephan, Durot, Liqun, He, Michael, Vanlandewijck, Catherine, Maclachlan, Suzel, Davanture, Nicola, Zamboni, Graham W, Knott, Sanjiv A, Luther, Christer, Betsholtz, Mauro, Delorenzi, Cathrin, Brisken, Tatiana V, Petrova

Publikováno v: Nature communications. 13(1)

The small intestinal villus tip is the first point of contact for lumen-derived substances including nutrients and microbial products. Electron microscopy studies from the early 1970s uncovered unusual spatial organization of small intestinal villus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c9aa29f41e420baf612d0e08e6591df
https://pubmed.ncbi.nlm.nih.gov/35810168

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

Autor: Myriam Baratin, Emeline Pollet, Julien Maurizio, Olivier Demaria, Toby Lawrence, Hiroaki Azukizawa, Suzel Davanture, Adriana Flores-Langarica, Chloe Foray, Marc Dalod, Mohamed Habbeddine, Christophe Verthuy

Publikováno v: Immunity. 42:627-639

SummaryMigratory non-lymphoid tissue dendritic cells (NLT-DCs) transport antigens to lymph nodes (LNs) and are required for protective immune responses in the context of inflammation and to promote tolerance to self-antigens in steady-state. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7172bed4e2735d65574777405b9d2b65
https://doi.org/10.1016/j.immuni.2015.03.003

Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells

Autor: Monika Frausto, Sylvia Luxen, Deborah Noack, Bruce E. Torbett, Suzel Davanture, Ulla G. Knaus

Publikováno v: Journal of cell science. 122(Pt 8)

Duox NADPH oxidases generate hydrogen peroxide at the air-liquid interface of the respiratory tract and at apical membranes of thyroid follicular cells. Inactivating mutations of Duox2 have been linked to congenital hypothyroidism, and epigenetic sil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e83acda2dbfb0edae702f4fb532f76
https://pubmed.ncbi.nlm.nih.gov/19339556

Transition from dimers to higher oligomeric forms occurs during the ATPase cycle of the ABCA1 transporter

Autor: Giovanna Chimini, Yannick Hamon, Michel Pierres, Suzel Davanture, Mélanie Alibert, Doriane Trompier

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2006, 281 (29), pp.20283-90. ⟨10.1074/jbc.M601072200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (29), pp.20283-90. ⟨10.1074/jbc.M601072200⟩

Fluorescence resonance energy transfer and native PAGE analytical techniques were employed to assess the quaternary structure of ABCA1, an ATP binding cassette transporter playing a crucial role in cellular lipid handling. These experimental approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17deb55bc6bec6b205d4d14b74214aeb
https://hal.science/hal-00165588