Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Suzanne Walker"'
Autor:
Irina Shlosman, Elayne M. Fivenson, Morgan S. A. Gilman, Tyler A. Sisley, Suzanne Walker, Thomas G. Bernhardt, Andrew C. Kruse, Joseph J. Loparo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The peptidoglycan (PG) cell wall protects bacteria against osmotic lysis and determines cell shape, making this structure a key antibiotic target. Peptidoglycan is a polymer of glycan chains connected by peptide crosslinks, and its synthesis
Externí odkaz:
https://doaj.org/article/46f4aabe611d4823be2a46c4d4c0f829
Autor:
Catrin M Beetham, Christopher F Schuster, Igor Kviatkovski, Marina Santiago, Suzanne Walker, Angelika Gründling
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011927 (2024)
Staphylococcus aureus is an opportunistic pathogen capable of causing many different human diseases. During colonization and infection, S. aureus will encounter a range of hostile environments, including acidic conditions such as those found on the s
Externí odkaz:
https://doaj.org/article/d1698710113844d49c7dd969cb4b01e9
Autor:
Xiao Wang, Sharyn Katz, John Miura, Giorgos Karakousis, Leonid Roshkovan, Suzanne Walker, Sally McNulty, Christine Ciunci, Keith Cengel, Corey J Langer, Melina E Marmarelis
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0275187 (2022)
BackgroundDiffuse malignant peritoneal mesothelioma (DMPM) is a rare variant of malignant mesothelioma, representing 10-15% of malignant mesothelioma cases. The preferred therapeutic approach is cytoreductive surgery (CRS) accompanied by hyperthermic
Externí odkaz:
https://doaj.org/article/292e1a5e154c404cb9b58769b1fc83b3
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 7, Pp 713-720 (2019)
Cyclin-dependent kinase 9 (CDK9), a key regulator of RNA-polymerase II, is a candidate drug target for cancers driven by transcriptional deregulation. Here we report a multi-omics-profiling of prostate cancer cell responses to CDK9 inhibition to iden
Externí odkaz:
https://doaj.org/article/34852b670cc44f2f86f927cf7351af29
Autor:
Clare L. Laut, William J. Perry, Alexander L. Metzger, Andy Weiss, Devin L. Stauff, Suzanne Walker, Richard M. Caprioli, Eric P. Skaar
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Bacillus anthracis is a spore-forming bacterium that causes devastating infections and has been used as a bioterror agent. This pathogen can survive hostile environments through the signaling activity of two-component systems, which couple e
Externí odkaz:
https://doaj.org/article/2816dfa936834795914d279b5029f5a0
Autor:
Samantha G Palace, Yi Wang, Daniel HF Rubin, Michael A Welsh, Tatum D Mortimer, Kevin Cole, David W Eyre, Suzanne Walker, Yonatan H Grad
Publikováno v:
eLife, Vol 9 (2020)
Increasing Neisseria gonorrhoeae resistance to ceftriaxone, the last antibiotic recommended for empiric gonorrhea treatment, poses an urgent public health threat. However, the genetic basis of reduced susceptibility to ceftriaxone is not completely u
Externí odkaz:
https://doaj.org/article/ac23c5c2218a4acdaa15d6f7afe4e4ec
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Recent data indicate that the metabolism of Mycobacterium tuberculosis (Mtb) inside its host cell is heavily dependent on cholesterol and fatty acids. Mtb exhibits a unique capacity to co-metabolize different carbon sources and the products
Externí odkaz:
https://doaj.org/article/f6c81e6275fa44bfb16513cf85230f7e
Autor:
Kathryn A Coe, Wonsik Lee, Madeleine C Stone, Gloria Komazin-Meredith, Timothy C Meredith, Yonatan H Grad, Suzanne Walker
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1007862 (2019)
Antibiotic-resistant Staphylococcus aureus remains a leading cause of antibiotic resistance-associated mortality in the United States. Given the reality of multi-drug resistant infections, it is imperative that we establish and maintain a pipeline of
Externí odkaz:
https://doaj.org/article/a3fcbfb5357d44ef956c36af3b3fe34d
Autor:
Patricia D A Rohs, Jackson Buss, Sue I Sim, Georgia R Squyres, Veerasak Srisuknimit, Mandy Smith, Hongbaek Cho, Megan Sjodt, Andrew C Kruse, Ethan C Garner, Suzanne Walker, Daniel E Kahne, Thomas G Bernhardt
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007726 (2018)
Cell elongation in rod-shaped bacteria is mediated by the Rod system, a conserved morphogenic complex that spatially controls cell wall assembly by the glycan polymerase RodA and crosslinking enzyme PBP2. Using Escherichia coli as a model system, we
Externí odkaz:
https://doaj.org/article/c69d3cdb91424e9cb61072c9e9650e6d
Autor:
Catherine Baranowski, Michael A Welsh, Lok-To Sham, Haig A Eskandarian, Hoong Chuin Lim, Karen J Kieser, Jeffrey C Wagner, John D McKinney, Georg E Fantner, Thomas R Ioerger, Suzanne Walker, Thomas G Bernhardt, Eric J Rubin, E Hesper Rego
Publikováno v:
eLife, Vol 7 (2018)
In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unus
Externí odkaz:
https://doaj.org/article/6695fdf7fa9f4cceb2741307353a71cf