Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Suzanne Tay"'
Autor:
Ning Liu, Mika Kosaka, Utkarsh Doshi, Jane R. Kenny, Albert P. Li, Peter Vuong, Suzanne Tay, Hoa Le, Susan Wong, Zhengyin Yan
Publikováno v:
Drug Metabolism Letters. 12:3-13
Background A recent advancement in isolation and cryopreservation has resulted in commercially available primary human enterocytes that express various drug metabolizing enzymes (DMEs) and transporters. The main objective of this study was to further
Autor:
Mingcui Liu, Aijun Lu, Shun Zhang, Heidi J.A. Wallweber, Matthew Volgraf, Bianca M. Liederer, David H. Hackos, Jacob Schwarz, Yuen Po-Wai, Elisia Villemure, Gauri Deshmukh, Xifeng Luo, Benjamin D. Sellers, Jesse E. Hanson, Tzu-Ming Wang, Jiang Yu, Kimberly Scearce-Levie, Cuong Ly, Guosheng Wu, Emile Plise, Suzanne Tay, Patrick J. Lupardus
Publikováno v:
ACS Medicinal Chemistry Letters. 8:84-89
The N-methyl-d-aspartate receptor (NMDAR) is an ionotropic glutamate receptor, gated by the endogenous coagonists glutamate and glycine, permeable to Ca2+ and Na+. NMDAR dysfunction is associated with numerous neurological and psychiatric disorders,
Autor:
Lisa Almond, M Jamei, K Rowland-Yeo, Suzanne Tay, Oliver Hatley, Sophie Mukadam, Krystle Okialda, Jane R. Kenny, Susan Wong, Iain Gardner, Amin Rostami-Hodjegan
Publikováno v:
Drug Metabolism and Disposition. 44:821-832
Using physiologically based pharmacokinetic modeling, we predicted the magnitude of drug-drug interactions (DDIs) for studies with rifampicin and seven CYP3A4 probe substrates administered i.v. (10 studies) or orally (19 studies). The results showed
Autor:
Rebecca M. Reese, Desiree Amm, Justin Ly, Aleksandr Kolesnikov, Christine E. Brotherton-Pleiss, Steven Do, Daniel G. Shore, David H. Hackos, Vishal Verma, Matthew Volgraf, Lesley J. Murray, Xiaofeng Xu, Guosheng Wu, Aijun Lu, Jun Chen, Baihua Hu, Martin E. Dahl, Huifen Chen, Yuen Po-Wai, Elisia Villemure, Yamin Zhang, Joseph P. Lyssikatos, Yong Chen, Brian Safina, Lan Wang, Anthony Estrada, Wienke Lange, Shawn David Erickson, Shannon D. Shields, Suzanne Tay
Publikováno v:
Journal of medicinal chemistry. 61(8)
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in sensory neurons where it functions as an irritant sensor for a plethora of electrophilic compounds and is implicated in pain, itch, and respiratory disease.
Autor:
Daniel F. Ortwine, Rebecca Erickson, Jonathan Hau, Binqing Wei, Charles Eigenbrot, Arna Katewa, James J. Crawford, Regina Choy, Dinah Misner, Georgette Castanedo, Pawan Bir Kohli, Suzanne Tay, Liming Dong, Lisa D. Belmont, Joseph W. Lubach, Wendy B. Young, Adam R. Johnson, Lichuan Liu, Harvey Wong, Leah Schutt, Karin Reif, Brent S. McKenzie, Melis Coraggio, Nico Ghilardi, Wendy Lee
Publikováno v:
Journal of medicinal chemistry. 61(6)
Bruton's tyrosine kinase (Btk) is a nonreceptor cytoplasmic tyrosine kinase involved in B-cell and myeloid cell activation, downstream of B-cell and Fcγ receptors, respectively. Preclinical studies have indicated that inhibition of Btk activity migh
Autor:
Grace Ka Yan Chan, Jae H. Chang, Vickie Tsui, Heidi J.A. Wallweber, Jeremy Murray, John Moffat, Huiyong Hu, Steven Do, Suzanne Tay, Veerendra Munugalavadla, Justin Ly, Eric Harstad, Dionysos Slaga, Jason Drummond, Allen J. Ebens, Ning Liu, Qi Chao, Aleksandr Kolesnikov, Matthew Volgraf, Xiaojing Wang
Publikováno v:
Journal of medicinal chemistry. 60(10)
Pim kinases have been identified as promising therapeutic targets for hematologic–oncology indications, including multiple myeloma and certain leukemia. Here, we describe our continued efforts in optimizing a lead series by improving bioavailabilit
Autor:
Elisia, Villemure, Matthew, Volgraf, Yu, Jiang, Guosheng, Wu, Cuong Q, Ly, Po-Wai, Yuen, Aijun, Lu, Xifeng, Luo, Mingcui, Liu, Shun, Zhang, Patrick J, Lupardus, Heidi J A, Wallweber, Bianca M, Liederer, Gauri, Deshmukh, Emile, Plise, Suzanne, Tay, Tzu-Ming, Wang, Jesse E, Hanson, David H, Hackos, Kimberly, Scearce-Levie, Jacob B, Schwarz, Benjamin D, Sellers
Publikováno v:
ACS medicinal chemistry letters. 8(1)
The
Autor:
Wendy Lee, Lionel Rouge, Joachim Rudolph, Sreemathy Ramaswamy, Klaus P. Hoeflich, Suzanne Tay, Lesley J. Murray, Ignacio Aliagas, Christopher E. Heise, Hank La, Weiru Wang, Robert Mintzer, James J. Crawford, Simon Mathieu
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(15)
A series of 4-azaindole-containing p21-activated kinase-1 (PAK1) inhibitors was prepared with the goal of improving physicochemical properties relative to an indole starting point. Indole 1 represented an attractive, non-basic scaffold with good PAK1
Autor:
Paul Reynen, Matthew Volgraf, Gauri Deshmukh, James B Herrington, Shun Zhang, Richard Pastor, Guosheng Wu, Liang Sun, David H. Hackos, Aijun Lu, Mingcui Liu, Bianca M. Liederer, Yanzhou Liu, Heidi J.A. Wallweber, Yuen Po-Wai, Elisia Villemure, Jacob Bradley Schwarz, Xifeng Luo, Akim Dirksen, Matthias G. A. Dietz, Yichin Liu, Benjamin D. Sellers, Amy Gustafson, Patrick J. Lupardus, Tzu-Ming Wang, Cuong Ly, Yuhong Fu, Jiang Yu, Jesse E. Hanson, Suzanne Tay, Kimberly Scearce-Levie, Emile Plise
Publikováno v:
Journal of medicinal chemistry. 59(6)
The N-methyl-D-aspartate receptor (NMDAR) is a Na(+) and Ca(2+) permeable ionotropic glutamate receptor that is activated by the coagonists glycine and glutamate. NMDARs are critical to synaptic signaling and plasticity, and their dysfunction has bee
Autor:
Erlie Marie Delarosa, Suzanne Tay, Leslie Wang, S. Cyrus Khojasteh, Jane R. Kenny, Sophie Mukadam, Jason Halladay, Daniel Tran
Publikováno v:
Drug Metabolism Letters. 6:43-53
Early in the drug discovery process, the identification of cytochrome P450 (CYP) time-dependent inhibition (TDI) is an important step for compound optimization. Here we describe a high-throughput, automated method for the evaluation of TDI utilizing