Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Suzanne S. M. Miedema"'
Autor:
Claire Bridel, Juami H. M. van Gils, Suzanne S. M. Miedema, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, August B. Smit, Annemieke J. M. Rozemuller, Sanne Abeln, Charlotte E. Teunissen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Frontotemporal lobar degeneration (FTLD) is characterized pathologically by neuronal and glial inclusions of hyperphosphorylated tau or by neuronal cytoplasmic inclusions of TDP43. This study aimed at deciphering the molecular mec
Externí odkaz:
https://doaj.org/article/b135612f94c34d819b4666a9e32da057
Autor:
Merel O. Mol, Suzanne S. M. Miedema, Shamiram Melhem, Ka Wan Li, Frank Koopmans, Harro Seelaar, Kurt Gottmann, Volkmar Lessmann, Netherlands Brain Bank, August B. Smit, John C. van Swieten, Jeroen G. J. van Rooij
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Semantic dementia (SD) is a clinical subtype of frontotemporal dementia consistent with the neuropathological diagnosis frontotemporal lobar degeneration (FTLD) TDP type C, with characteristic round TDP-43 protein inclusions in the dentate g
Externí odkaz:
https://doaj.org/article/8c2d7e6c8ed449b1816eb6adb95fcab9
Autor:
Suzanne S. M. Miedema, Merel O. Mol, Frank T. W. Koopmans, David C. Hondius, Pim van Nierop, Kevin Menden, Christina F. de Veij Mestdagh, Jeroen van Rooij, Andrea B. Ganz, Iryna Paliukhovich, Shamiram Melhem, Ka Wan Li, Henne Holstege, Patrizia Rizzu, Ronald E. van Kesteren, John C. van Swieten, Peter Heutink, August B. Smit
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-20 (2022)
Abstract Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices at an early age of onset. The disorder shows considerable clinical, pathological, and genetic heterogeneity. Here we investigated the proteom
Externí odkaz:
https://doaj.org/article/3d65d481ed034fb3accf44dce1155278
Autor:
Christina F. de Veij Mestdagh, Jaap A. Timmerman, Frank Koopmans, Iryna Paliukhovich, Suzanne S. M. Miedema, Maaike Goris, Rolinka J. van der Loo, Guido Krenning, Ka Wan Li, Huibert D. Mansvelder, August B. Smit, Robert H. Henning, Ronald E. van Kesteren
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Hibernation induces neurodegeneration-like changes in the brain, which are completely reversed upon arousal. Hibernation-induced plasticity may therefore be of great relevance for the treatment of neurodegenerative diseases, but remains larg
Externí odkaz:
https://doaj.org/article/79d911a2ec34496183b119acd53c6f51
Autor:
Marlijn van der Poel, Thomas Ulas, Mark R. Mizee, Cheng-Chih Hsiao, Suzanne S. M. Miedema, Adelia, Karianne G. Schuurman, Boy Helder, Sander W. Tas, Joachim L. Schultze, Jörg Hamann, Inge Huitinga
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
It is unclear if early pathological changes in normal-appearing multiple sclerosis (MS) tissue are reflected by molecular changes in microglia, which might contribute to lesion initiation. Here, authors demonstrate significant intrinsic differences i
Externí odkaz:
https://doaj.org/article/3dba4ae06f6a4f6d8d2e10b0073b7819
Autor:
Merel O. Mol, Suzanne S. M. Miedema, John C. van Swieten, Jeroen G. J. van Rooij, Elise G. P. Dopper
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10298 (2021)
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder clinically characterized by behavioral, language, and motor symptoms, with major impact on the lives of patients and their families. TDP-43 proteinopathy is the underlying neuro
Externí odkaz:
https://doaj.org/article/e7d2c7085c5649a88034d9843f4351ac
Autor:
Sophie J. F. van der Spek, Miguel A. Gonzalez-Lozano, Frank Koopmans, Suzanne S. M. Miedema, Iryna Paliukhovich, August B. Smit, Ka Wan Li
Publikováno v:
Cells, Vol 10, Iss 7, p 1588 (2021)
Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the human population, for which there is currently no cure. The cause of AD is unknown; however, the toxic effects of amyloid-β (Aβ) are believed to play a role in its onse
Externí odkaz:
https://doaj.org/article/07f2bcdc8e494fa9b236d1a9b1fe4e80
Autor:
Joyce B. J. van Meurs, Takuya Oshima, Harro Seelaar, John C. van Swieten, André G. Uitterlinden, Netherlands Brain Bank, August B. Smit, Ronald E. van Kesteren, Bart J. L. Eggen, Laura Donker Kaat, Francesca Paron, Shamiram Melhem, Suzanne S M Miedema, Pascal P. Arp, Jeroen van Rooij, Merel O. Mol, Pelle van der Wal, Emanuele Buratti
Publikováno v:
Brain, 143, 3827-3841. Oxford University Press
Brain, 143(12), 3827-3841. Oxford University Press
van Rooij, J, Mol, M, Melhem, S, van der Wal, P, Arp, P, Paron, F, Donker Kaat, L, Seelaar, H, Brain Bank, N, Miedema, S S M, Oshima, T, Eggen, B J, Uitterlinden, A G, van Meurs, J B J, van Kesteren, RE, Smit, A B, Buratti, E & van Swieten, J C 2020, ' Somatic TARDBP variants as a cause of semantic dementia ', Brain, vol. 143, no. 12, pp. 3827-3841 . https://doi.org/10.1093/brain/awaa317
Brain
Brain, 143(12), 3827-3841. Oxford University Press
van Rooij, J, Mol, M, Melhem, S, van der Wal, P, Arp, P, Paron, F, Donker Kaat, L, Seelaar, H, Brain Bank, N, Miedema, S S M, Oshima, T, Eggen, B J, Uitterlinden, A G, van Meurs, J B J, van Kesteren, RE, Smit, A B, Buratti, E & van Swieten, J C 2020, ' Somatic TARDBP variants as a cause of semantic dementia ', Brain, vol. 143, no. 12, pp. 3827-3841 . https://doi.org/10.1093/brain/awaa317
Brain
Could somatic variants arising during brain development give rise to non-hereditary neurodegenerative disease? By sequencing DNA from brain tissue and blood from the same semantic dementia patients, van Rooij et al. identify brain-specific somatic TA
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10298, p 10298 (2021)
Mol, M O, Miedema, S S M, van Swieten, J C, van Rooij, J G J & Dopper, E G P 2021, ' Molecular pathways involved in frontotemporal lobar degeneration with tdp-43 proteinopathy : What can we learn from proteomics? ', International Journal of Molecular Sciences, vol. 22, no. 19, 10298 . https://doi.org/10.3390/ijms221910298
International Journal of Molecular Sciences
Mol, M O, Miedema, S S M, van Swieten, J C, van Rooij, J G J & Dopper, E G P 2021, ' Molecular pathways involved in frontotemporal lobar degeneration with tdp-43 proteinopathy : What can we learn from proteomics? ', International Journal of Molecular Sciences, vol. 22, no. 19, 10298 . https://doi.org/10.3390/ijms221910298
International Journal of Molecular Sciences
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder clinically characterized by behavioral, language, and motor symptoms, with major impact on the lives of patients and their families. TDP-43 proteinopathy is the underlying neuro
Autor:
Miguel A. Gonzalez-Lozano, Ka Wan Li, Frank Koopmans, Suzanne S M Miedema, Sophie J. F. van der Spek, August B. Smit, Iryna Paliukhovich
Publikováno v:
Cells, Vol 10, Iss 1588, p 1588 (2021)
Cells
van der Spek, S J F, Gonzalez-Lozano, M A, Koopmans, F, Miedema, S S M, Paliukhovich, I, Smit, A B & Li, K W 2021, ' Age-Dependent Hippocampal Proteomics in the APP/PS1 Alzheimer Mouse Model : A Comparative Analysis with Classical SWATH/DIA and directDIA Approaches ', Cells, vol. 10, no. 7 . https://doi.org/10.3390/cells10071588
Cells, 10(7). MDPI Multidisciplinary Digital Publishing Institute
Volume 10
Issue 7
Cells
van der Spek, S J F, Gonzalez-Lozano, M A, Koopmans, F, Miedema, S S M, Paliukhovich, I, Smit, A B & Li, K W 2021, ' Age-Dependent Hippocampal Proteomics in the APP/PS1 Alzheimer Mouse Model : A Comparative Analysis with Classical SWATH/DIA and directDIA Approaches ', Cells, vol. 10, no. 7 . https://doi.org/10.3390/cells10071588
Cells, 10(7). MDPI Multidisciplinary Digital Publishing Institute
Volume 10
Issue 7
Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the human population, for which there is currently no cure. The cause of AD is unknown
however, the toxic effects of amyloid-β (Aβ) are believed to play a role in its
however, the toxic effects of amyloid-β (Aβ) are believed to play a role in its