Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Suzanne R.L. Young"'
Autor:
Komal Jhaveri, Nadia Harbeck, Philippe Aftimos, Sung-Bae Kim, Xavier Pivot, Cristina Saura, Giuseppe Curigliano, Monica Casalnuovo, Xuejing Aimee Wang, Suzanne R.L. Young, Lillian Smyth, Joyce O'Shaughnessy
Publikováno v:
Cancer Research. 82:OT2-11
Background: The estrogen receptor (ER) is the key therapeutic target for ER-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Novel degraders of ER may overcome resistance to available endocrine therapy (ET) whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8e76dd3d7e2e814eb5ae0259abb5005
https://doi.org/10.1158/1538-7445.sabcs21-ot2-11-01
https://doi.org/10.1158/1538-7445.sabcs21-ot2-11-01
Autor:
Muralidhar Beeram, Erika Hamilton, Philippe Aftimos, Xuejing Aimee Wang, Meena Okera, Sung-Bae Kim, Peter A. Kaufman, Kalyan Banda, Tarek Meniawy, Joohyuk Sohn, Sarah Sammons, Cynthia X. Ma, Suzanne R.L. Young, Rinath Jeselsohn, J. Thaddeus Beck, Kathleen K. Harnden, Komal Jhaveri, Cristina Saura, Kan Yonemori, Elgene Lim
Publikováno v:
Journal of Clinical Oncology. 39:1050-1050
1050 Background: Novel degraders and antagonists of ER are under evaluation in aBC, to overcome both ER mediated resistance and the bioavailability and dosing limitations of fulvestrant, the only approved SERD. ER is also overexpressed in ̃80% of EE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a9341ea6d19ca46f1f9a7a6038bdf1a
https://doi.org/10.1200/jco.2021.39.15_suppl.1050
https://doi.org/10.1200/jco.2021.39.15_suppl.1050
Focal Adhesion Kinase Is Important for Fluid Shear Stress–Induced Mechanotransduction in Osteoblasts
Publikováno v:
Journal of Bone and Mineral Research. 24:411-424
Mechanical loading of bone is important for maintenance of bone mass and structural stability of the skeleton. When bone is mechanically loaded, movement of fluid within the spaces surrounding bone cells generates fluid shear stress (FSS) that stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37083e2a0355a591ea34d89255a5689
https://doi.org/10.1359/jbmr.081102
https://doi.org/10.1359/jbmr.081102
Autor:
David G. Skalnik, Suzanne R.L. Young
Publikováno v:
DNA and Cell Biology. 26:80-90
CXXC finger protein 1 (CFP1) binds to unmethylated CpG motifs in DNA, is a component of the mammalian Set1 histone methyltransferase complex, and is essential for zebrafish hematopoiesis. Transfection of the human PLB-985 myeloid cell line with a sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912117ab046a27d32a7d0e33f6a4b4f6
https://doi.org/10.1089/dna.2006.0535
https://doi.org/10.1089/dna.2006.0535
Publikováno v:
Journal of Biological Chemistry. 281:37034-37044
CXXC finger protein 1 (CFP1) binds to unmethylated CpG dinucleotides and is a component of the Set1 histone methyltransferase complex. Mice lacking CFP1 suffer a peri-implantation lethal phenotype, and CFP1-deficient embryonic stem cells are viable b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e3115349d019edd4f83e2d9715ac54
https://doi.org/10.1074/jbc.m604546200
https://doi.org/10.1074/jbc.m604546200
Autor:
Diana L. Carlone, Joseph C. Ruiz, Suzanne R.L. Young, David G. Skalnik, Jeong Heon Lee, Jill Sergesketter Butler, Erika A. Dobrota
Publikováno v:
Molecular and Cellular Biology. 25:4881-4891
The CpG dinucleotide is an important regulatory component of mammalian genomes. The cytosine of this dinucleotide serves as the target for methylation by DNA methyltransferase (Dnmt) enzymes, which functions as a critical epigenetic modification of D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5f5748a1232b17a78edd183000862b
https://doi.org/10.1128/mcb.25.12.4881-4891.2005
https://doi.org/10.1128/mcb.25.12.4881-4891.2005
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16026 (2011)
PLoS ONE
PLoS ONE
Mechanotransduction, the process by which cells convert external mechanical stimuli such as fluid shear stress (FSS) into biochemical changes, plays a critical role in maintenance of the skeleton. We have proposed that mechanical stimulation by FSS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5724782b9a44d315d0d505929692e21
http://europepmc.org/articles/PMC3026802?pdf=render
http://europepmc.org/articles/PMC3026802?pdf=render
When bone is mechanically loaded fluid shear stress (FSS) is generated as a result of the movement of interstitial fluid across the membranes of osteoblasts and osteocytes. This external mechanical loading stimulates changes in the activity of cytopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac4c50f97c590adf55336cda3a8d79c
https://europepmc.org/articles/PMC2891440/
https://europepmc.org/articles/PMC2891440/
Publikováno v:
Mechanosensitivity and Mechanotransduction ISBN: 9789048198801
Bone is a dynamic tissue that adjusts its structure over time to adapt to changes in mechanical load. This adaptive ability is critical to skeletal development and maintenance of optimal skeletal health throughout life. Imbalances in the ability of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c6b4e10ebecae146a386f5202da87cd
https://doi.org/10.1007/978-90-481-9881-8_12
https://doi.org/10.1007/978-90-481-9881-8_12
Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts
Publikováno v:
Journal of Bone and Mineral Research. 28:2431-2431
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::125f50ad1701967dffd970e432c0c3b4
https://doi.org/10.1002/jbmr.2046
https://doi.org/10.1002/jbmr.2046