Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Suzanne R, Thorpe"'
Autor:
Jonathan W.C. Brock, Alicia J. Jenkins, Timothy J. Lyons, Richard L. Klein, Eunsil Yim, Maria Lopes-Virella, Rickey E. Carter, (DCCT/EDIC) Research Group, Suzanne R. Thorpe, John W. Baynes
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 4, Pp 847-855 (2008)
Cardiovascular disease is a major cause of morbidity and premature mortality in diabetes. HDL plays an important role in limiting vascular damage by removing cholesterol and cholesteryl ester hydroperoxides from oxidized low density lipoprotein and f
Externí odkaz:
https://doaj.org/article/94796c5df90a4b698aef377de2232a2c
Autor:
Andrzej S. Januszewski, Nathan L. Alderson, Alicia J. Jenkins, Suzanne R. Thorpe, John W. Baynes
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 7, Pp 1440-1449 (2005)
Chemical modification of proteins by advanced glycation and lipoxidation end products is implicated in the pathogenesis of macrovascular disease in aging and diabetes. To identify biomarkers of the lipoxidative modification of protein, we studied the
Externí odkaz:
https://doaj.org/article/7c839f99536d448fba1d1fb10a849551
Autor:
Gabriel Virella, Suzanne R. Thorpe, Nathan L. Alderson, M. Brooks Derrick, Charlyne Chassereau, J. Matthew Rhett, Maria F. Lopes-Virella
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 10, Pp 1859-1867 (2004)
Humans and laboratory animals recognize human modified LDL as immunogenic. Immune complexes (ICs) isolated from human sera contain malondialdehyde-modified LDL (MDA-LDL) and N ε(carboxymethyl)lysine-modified LDL (CML-LDL) as well as antibodies react
Externí odkaz:
https://doaj.org/article/849fa92d82034bf7958d07475752ed3f
Autor:
Gabriel Virella, Suzanne R. Thorpe, Nathan L. Alderson, Elias M. Stephan, Daniel Atchley, Francesco Wagner, Maria F. Lopes-Virella
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 3, Pp 487-493 (2003)
Advanced glycosylation end-products (AGEs) are believed to play a significant role in the development of vascular complications in diabetic patients. One such product, AGE-LDL, has been shown to be immunogenic. In this report, we describe the isolati
Externí odkaz:
https://doaj.org/article/5f8ef3b78c5e4cc3b193093b6cdf380c
Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: A prospective study
Autor:
Suzanne R. Thorpe, Timothy J. Lyons, Maria F. Lopes-Virella, Arpita Basu, Julie A. Stoner, Alicia J. Jenkins, Richard L. Klein, W. Timothy Garvey
Publikováno v:
Atherosclerosis. 236:188-195
Plasma total homocysteine (tHcy) has been positively associated with carotid intima-media thickness (IMT) in non-diabetic populations and in a few cross-sectional studies of diabetic patients. We investigated cross-sectional and prospective associati
Autor:
Mathur Rajesh, Ryoji Nagai, Matthew J. Jepson, Suzanne R. Thorpe, James A. Carson, John W. Baynes, Norma Frizzell
Publikováno v:
Journal of Biological Chemistry. 284:25772-25781
S-(2-Succinyl)cysteine (2SC) is formed by reaction of the Krebs cycle intermediate fumarate with cysteine residues in protein, a process termed succination of protein. Both fumarate and succination of proteins are increased in adipocytes cultured in
Autor:
Peter P. Nawroth, Elizabeth K. Deemer, Per M. Humpert, Martin Andrassy, Ezzat M. Awad, Stefan Hofer, Michael Kasper, Angelika Bierhaus, Suzanne R. Thorpe, Markus Schwaninger, Ivan K. Lukic, Markus A. Weigand, Erwin Schleicher
Publikováno v:
Journal of Leukocyte Biology. 86:589-597
Advanced glycation endproducts (AGEs) act as potential contaminants of infusion solutions boosting inflammation in experimental sepsis. HSA preparations for i.v. use are administered in critically ill patients. Although increasing intravascular osmot
Publikováno v:
Annals of the New York Academy of Sciences. 1126:272-275
S-(2-succinyl)cysteine (2SC) is a chemical modification of proteins formed by a Michael addition reaction between the Krebs cycle intermediate, fumarate, and thiol groups in protein—a process known as succination of protein. Succination causes irre
Publikováno v:
Diabetes. 57:41-49
OBJECTIVE—S-(2-succinyl)cysteine (2SC) is formed by a Michael addition reaction of the Krebs cycle intermediate, fumarate, with cysteine residues in protein. We investigated the role of fumarate in chemical modification and inhibition of the sulfhy
Autor:
John W. Baynes, Norma Frizzell, John E. Baatz, Michael D. Walla, Jonathan W. C. Brock, Suzanne R. Thorpe, Jennifer R. Bethard, Matthew Blatnik, Ryoji Nagai
Publikováno v:
Journal of Biological Chemistry. 282:34219-34228
Although obesity is a risk factor for development of type 2 diabetes and chemical modification of proteins by advanced glycoxidation and lipoxidation end products is implicated in the development of diabetic complications, little is known about the c