Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Suzanne Moreland"'
Autor:
John T. Hunt, Suzanne Moreland, Maria L. Webb, Diane M. McMullen, Mark S. Bolgar, Ving G. Lee, Eddie C.-K. Liu
Publikováno v:
International Journal of Peptide and Protein Research. 42:249-258
While incorporation of penicillamine residues (Pen; beta,beta-dimethyl cysteine) into a peptide can cause dramatic changes in biological activity, the tendency of Pen to form mixed disulfides should also allow the exploitation of the steric bulk of t
Autor:
Sharon N. Bisaha, Rongan Zhang, Maria L. Webb, Natesan Murugesan, Eddie C.-K. Liu, Suzanne Moreland, Zhengxiang Gu, Steven H. Spergel, Philip D. Stein, Joel C. Barrish
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:517-520
A number of 4'-heterocyclic biphenylsulfonamide derivatives, formally derived from BMS-193884 (1) by replacing the oxazole ring with other heterocyclic rings, are potent and selective endothelin A (ET(A)) receptor antagonists. Among the analogues exa
Autor:
Suzanne Moreland, Rongan Zhang, Eddie C.-K. Liu, Richard A. Morrison, Maria L. Webb, Natesan Murugesan, Arvind Mathur, Steven H. Spergel, Philip D. Stein, Joel C. Barrish, Zhengxiang Gu, Eileen Bird, T.L. Waldron, Anthony M. Marino, Leslie Leith
Publikováno v:
Journal of Medicinal Chemistry. 43:3111-3117
The synthesis and structure-activity relationship (SAR) studies of a series of 4'-oxazolyl-N-(3,4-dimethyl-5-isoxazolyl)[1, 1'-biphenyl]-2-sulfonamide derivatives as endothelin-A (ET(A)) receptor antagonists are described. The data reveal a remarkabl
Autor:
Natesan Murugesan, Zhengxiang Gu, Philip D. Stein, Sharon Bisaha, Steve Spergel, Ravi Girotra, Ving G. Lee, John Lloyd, Raj N. Misra, Joan Schmidt, Arvind Mathur, Leslie Stratton, Yolanda F. Kelly, Eileen Bird, Tom Waldron, Eddie C.-K. Liu, Rongan Zhang, Helen Lee, Randy Serafino, Benoni Abboa-Offei, Parker Mathers, Mary Giancarli, Andrea Ann Seymour, Maria L. Webb, Suzanne Moreland, Joel C. Barrish, John T. Hunt
Publikováno v:
Journal of Medicinal Chemistry. 41:5198-5218
Substitution at the ortho position of N-(3,4-dimethyl-5-isoxazolyl) benzenesulfonamide led to the identification of the biphenylsulfonamides as a novel series of endothelin-A (ETA) selective antagonists. Appropriate substitutions on the pendant pheny
Publikováno v:
European Journal of Pharmacology. 317:91-96
Thromboxane A2/prostaglandin endoperoxide receptor antagonists were studied in rat and guinea-pig aortas contracted with U-46619 (9,11-dideoxy-11 alpha,9 alpha-epoxymethanoprostaglandin F2 alpha) or 8-epi-prostaglandin F2 alpha. In rat aorta, the ant
Autor:
Maria T. Valentine, Nancy L. Goller, Tonya Jenkins-West, Stephen K. Durham, Helen Weber, Patricia Ferrer, Christopher J. Molloy, Suzanne Moreland
Publikováno v:
Scopus-Elsevier
Vascular smooth muscle cell (SMC) proliferation is an important component in the development of restenosis. Because endothelin (ET) has been reported to act as an SMC mitogen, we postulated that the orally active ET A receptor antagonist BMS-182874 w
Publikováno v:
European Journal of Pharmacology. 287:279-285
The functional importance of endothelin ETA and ETB receptors in selected arterial and venous smooth muscle preparations was characterized. Endothelin-1 induced force in the saphenous and jugular veins is normally mediated by endothelin ETB-like rece
Autor:
Steven Dzwonczyk, Gary J. Grover, Diane M. McMullen, Paul G. Sleph, Suzanne Moreland, Charles S. Parham, Diane E. Normandin
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:289-294
SummarySQ 32,926 and SQ 32,547, two dihydropyrimidine calcium channel blockers, were characterized as potent inhibitors of depolarization-induced contractions of isolated smooth muscle preparations. In rat aorta, the IC50 values were 5.5 nM for SQ 32
Publikováno v:
Journal of Vascular Research. 32:313-319
Rabbit thoracic aorta was used to determine the effects of decreasing PO2 on the mechanical properties of contractions in response to norepinephrine (NE) and KCl. Aortae were aerated with 45% O2/5% CO2/50% N2 and stimulated with 10 microM NE or 50 mM
Autor:
R.B. Cohen, Kenneth E.J. Dickinson, Zhengxiang Gu, S. Skwish, Michael A. Poss, Randy Serafino, James R. Powell, Carol L. Delaney, Suzanne Moreland, Denis E. Ryono
Publikováno v:
British Journal of Pharmacology. 113:179-189
1. This study compares the activity of BMS-180560 (2-butyl-1-chloro-1-[[1-[2-(2H-tetrazol-5-yl)phenyl]-1H-indol-4- yl]methyl]-1H-imidazole-5-carboxylic acid), an insurmountable angiotensin II (AII) receptor antagonist, with that of losartan and EXP31