SAT-741 Salivary Cortisol and Cortisone Measurement Provide a Novel and Non-Invasive Method of Monitoring Medical Therapy in Cushing’s Syndrome

Autor: Safwaan Adam, Brian G. Keevil, Anna-Elisabeth Minder Steimer, Suzanne Meredith, Megan Elizabeth Manson, Anne White, Peter J Trainer, Claire E Higham, Elizabeth Cottrell, Noor Rafhati Adyani Abdullah, Phillip J. Monaghan

Publikováno v: Journal of the Endocrine Society

Introduction: Salivary glucocorticoids (cortisol [SalF], cortisone [SalE]) are collected non-invasively, unaffected by variation in cortisol binding globulin (CBG) and an established tool in the investigation of Cushing’s syndrome (CS). We have pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3a2394c4bec6ad8f4a6756c8bff903
https://doi.org/10.1210/jendso/bvaa046.1788

International survey on high- and low-dose synacthen test and assessment of accuracy in preparing low-dose synacthen

Autor: Pooja Sachdev, Neil Wright, Anne White, Leanne Walker, Alexandra S Cross, Nils Krone, Charlotte Elder, Suzanne Meredith, E. Helen Kemp, Richard J. Ross

Publikováno v: Cross, A S, Kemp, E H, White, A, Walker, L, Meredith, S, Sachdev, P, Krone, N P, Ross, R J, Wright, N P & Elder, C J 2018, ' International survey on high-and low-dose synacthen test and assessment of accuracy in preparing low-dose synacthen ', Clinical Endocrinology . https://doi.org/10.1111/cen.13559

ObjectiveThe short synacthen test (SST) is widely used to assess patients for adrenal insufficiency but the frequency and protocols used across different centres for the low-dose test (LDT) are unknown. This study aimed to survey centres and test the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1ea0e85db6335b3bafd6228c25a9f8
https://doi.org/10.1111/cen.13559

Salivary cortisone is a potential surrogate for serum cortisol measurement

Autor: Claire E Higham, Alison Davies, Anne White, Richard F. Preziosi, Suzanne Meredith, Anna Minder, Peter J Trainer, Elizabeth Cottrell, Brian G. Keevil, Safwaan Adam

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84742ab3023f5615a23d2d177f09a947
https://doi.org/10.1530/endoabs.44.p39

Irradiation Decreases the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo

Autor: Roya Behrouzi, Anne White, Muhammad Babur, Jennifer L. Bryant, Philip Riddell, Suzanne Meredith, Kaye J. Williams

Publikováno v: PLOS ONE
Meredith, S, Bryant, J, Babur, M, Riddell, P W, Behrouzi, R, Williams, K & White, A 2016, ' Irradiation Decreases the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo. ', P L o S One, vol. 11, no. 2, e0148404 . https://doi.org/10.1371/journal.pone.0148404
PLoS ONE, Vol 11, Iss 2, p e0148404 (2016)
PLoS ONE

Background Small cell lung cancer (SCLC) is an extremely aggressive disease, commonly displaying therapy-resistant relapse. We have previously identified neuroendocrine and epithelial phenotypes in SCLC tumours and the neuroendocrine marker, pro-opio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d8c47a6ce1d3b3942e445026a80909

Glucocorticoid receptor-mediated apoptosis in small-cell lung cancer requires interaction with BCL2

Autor: Anne White, Alison Davies, George Schlossmacher, Suzanne Meredith, Eleanor Platt

Publikováno v: University of Manchester-PURE

Small-cell lung cancer (SCLC) tumours are highly aggressive. At the time of diagnosis, patients have often developed metastases, and overall prognosis is particularly poor, making effective treatment difficult. Novel mechanisms need to be identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9b1cdda3c854c9acdac77254ac844
https://pubmed.ncbi.nlm.nih.gov/24036132