Výsledky vyhledávání - "Suzanne M.R. Southward"

Relationships among tumor burden, tumor size, and the changing concentrations of fibrin degradation products and fibrinolytic factors in the pleural effusions of rabbits with VX2 lung tumors

Autor: Mary Richardson, Bonnie Ross, Gurmit Singh, Bryan J. Clarke, Suzanne M.R. Southward, Mark W.C. Hatton

Publikováno v: Journal of Laboratory and Clinical Medicine. 147:27-35

The VX2 tumor is derived from a papilloma virus-induced rabbit epithelial cell line. If VX2 tumor cells (trapped in a plasma clot) are introduced intravenously into NZW rabbits, the cells lodge in the lung capillary bed and produce tumors. Independen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b882f56229797e90378331624a3948a4
https://doi.org/10.1016/j.lab.2005.08.014

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Fibrinogen catabolism within the procoagulant VX-2 tumor of rabbit lung in vivo: effluxing fibrin(ogen) fragments contain antiangiogenic activity

Autor: Morris A. Blajchman, Bonnie Ross, Kimberly Legault, Mark W.C. Hatton, Gurmit Singh, Suzanne M.R. Southward, Laszlo Bajzar, Bryan J. Clarke, Mary Richardson

Publikováno v: Journal of Laboratory and Clinical Medicine. 143:241-254

Many types of solid tumors are known to be procoagulant environments. This is partly because a hyperpermeable vascular system within the tumor allows plasma hemostatic factors to accumulate in relatively high concentrations in the stroma, and many so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c02832ca02c9210e70e9dce6fb916cf
https://doi.org/10.1016/j.lab.2004.01.006

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Angiostatin II is the predominant glycoform in pleural effusates of rabbit VX-2 lung tumors

Autor: Kimberly Legault, Lindsay Marien, Darren Korbie, Bryan J. Clarke, Bonnie Ross, Morris A. Blajchman, Mark W.C. Hatton, Gurmit Singh, Mary Richardson, Suzanne M.R. Southward

Publikováno v: Journal of Laboratory and Clinical Medicine. 139:316-323

Angiostatin (AST), a polypeptide with potent antiangiogenic properties, is released proteolytically from plasminogen in vivo. Plasminogen exists naturally in plasma as two glycoforms (PLGs), I and II. Recently it was shown with the use of a chick-emb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2c6f2efa72d981772262762c2f19c0
https://doi.org/10.1067/mlc.2002.123267

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Metabolism of rabbit plasma-derived factor VII in relation to prothrombin in rabbits

Autor: Suzanne M.R. Southward, Sampath Sridhara, Bryan J. Clarke, Bonnie Ross, Morris A. Blajchman, Mark W.C. Hatton, Myron Kulzcycky

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 281:E507-E515

In the human circulation, factor VII is present in relatively low plasma concentration (0.01 μM) and has been reported to have a short half-life ( t½; 6 h). In contrast, prothrombin is present in a relatively high plasma concentration (2 μM) and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30fa6ae4b659a824c57bb165d914d4f
https://doi.org/10.1152/ajpendo.2001.281.3.e507

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Metabolism of rabbit angiostatin glycoforms I and II in rabbits: Angiostatin-I leaves the intravascular space faster and appears to have greater anti-angiogenic activity than angiostatin-II

Autor: Eric Seidlitz, Steven Day, Mark W.C. Hatton, Mary Richardson, Marnie DeReske, Suzanne M.R. Southward, Gurmit Singh, Bonnie Ross

Publikováno v: Journal of Laboratory and Clinical Medicine. 138:83-93

Plasminogen (PLG) exists in the circulation as two glycoforms, I and II. Angiostatin (AST) is a polypeptide that has been cleaved from the kringle region of PLG and has strong anti-angiogenic properties. AST-I and AST-II, which consisted only of krin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbae70885932b84f8231563365349382
https://doi.org/10.1067/mlc.2001.116679

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Plasminogen II accumulates five times faster than plasminogen I at the site of a balloon de-endothelializing injury in vivo to the rabbit aorta: Comparison with other hemostatic proteins

Autor: Steven Day, Marnie DeReske, Mark W.C. Hatton, Mary Richardson, Suzanne M.R. Southward, Bonnie Ross

Publikováno v: Journal of Laboratory and Clinical Medicine. 134:260-266

In the rabbit blood stream, plasminogen circulates as two glycoforms, plasminogen I (PLG-I) and plasminogen II (PLG-II), in a molar ratio of 1:2.2. To compare their relative behaviors toward a site of vascular injury, radiolabeled samples of PLG-I an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f319590c4bb8ecb0d4e13678b5529e2f
https://doi.org/10.1016/s0022-2143(99)90206-8

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Uptake of heparin cofactor II and antithrombin into the aorta wall after a deendothelializing injury in vivo: Comparison with the behaviors of prothrombin and fibrinogen

Autor: Bonnie Ross, Hugh Hoogendoorn, Marnie DeReske, Suzanne M.R. Southward, Mary Richardson, Morris A. Blajchman, Mark W.C. Hatton

Publikováno v: Journal of Laboratory and Clinical Medicine. 133:81-87

The initiation of a denuding injury to the vascular endothelium rapidly leads to a deposition of platelets and fibrin at the site of injury. We have measured previously the responses of rabbit fibrinogen, prothrombin, and antithrombin to a deendothel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f21f3a2fd327fa9dcb287ec83327c73
https://doi.org/10.1053/lc.1999.v133.a94657

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The Procoagulant State of the VX-2 Tumor in Rabbit Lung In Vivo

Autor: Mary Richardson, Morris A. Blajchman, Mark W.C. Hatton, Suzanne M.R. Southward, Bonnie Ross, Leslie Bardossy, Marnie DeReske

Publikováno v: Thrombosis and Haemostasis. 82:1694-1702

SummaryDuring their growth, many malignant solid tumors elicit a hemostatic response in the host. In this report, the fluxes of various rabbit plasma hemostatic proteins into pulmonary VX-2 tumors have been measured in vivo. VX-2 cells were contained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e6efbc1a093b7d83fc30eb97fb0edfe
https://doi.org/10.1055/s-0037-1614901

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Pretreatment of Rabbits With Either Hirudin, Ancrod, or Warfarin Significantly Reduces the Immediate Uptake of Fibrinogen and Platelets by the Deendothelialized Aorta Wall After Balloon-Catheter Injury In Vivo

Autor: Bonnie Ross, Marnie DeReske, Suzanne M.R. Southward, Mark W.C. Hatton, Mary Richardson

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 18:816-824

Abstract —Fibrinogen and platelets rapidly saturate the exposed subendothelium of a freshly deendothelialized aorta in vivo. As thrombin generated within the site of injury is largely responsible for fibrin(ogen) deposition, we questioned whether v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6af6f0cb764515981527c67d201a62b
https://doi.org/10.1161/01.atv.18.5.816

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Turnover and fate of fibrinogen and platelets at the rabbit aorta wall immediately after a balloon de-endothelializing injury in vivo

Autor: Mark W.C. Hatton, Mary Richardson, Marnie Timleck, Suzanne M.R. Southward, Bonnie Ross

Publikováno v: Thrombosis and haemostasis. 96(1)

A de-endothelializing injury to the artery wall in vivo results in a rapid procoagulant response at the surface of the exposed subendothelium. Activated tissue factor (TF)-bearing cells and hemostasis factors located at the site of injury respond by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79639a1fda7bb2e7dbf947623b4fff1a
https://pubmed.ncbi.nlm.nih.gov/16807652

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