Výsledky vyhledávání - "Suzanne M. Weber"

Reduction of Cocaine Self-Administration and D3 Receptor-Mediated Behavior by Two Novel Dopamine D3 Receptor-Selective Partial Agonists, OS-3-106 and WW-III-55

Autor: Robert H. Mach, Kayla N. Chandler, Robert R. Luedtke, Romina F. Schaan, Amy L. Loriaux, Suzanne M. Weber, Janet L. Neisewander, T. H. C. Cheung, Jeffrey D. Lenz

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 347:410-423

Dopamine D3 receptor (D3R)-selective compounds may be useful medications for cocaine dependence. In this study, we identified two novel arylamide phenylpiperazines, OS-3-106 and WW-III-55, as partial agonists at the D3R in the adenylyl cyclase inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60265a667ebda3a6aa1b7ee125f4f0b
https://doi.org/10.1124/jpet.112.202911

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Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats

Autor: B. C. Nolan, T. H. C. Cheung, Janet L. Neisewander, Natalie A. Peartree, Robert T. Luedtke, J. P. Durbin, Lindsey R. Hammerslag, Robert H. Mach, Suzanne M. Weber

Publikováno v: Neuropharmacology. 63:1346-1359

This study examined cocaine self-administration after pretreatments with three structurally related compounds that bind selectively to dopamine D3 receptors (D3Rs) relative to the D2 receptor subtype (D2Rs) and exhibit varying intrinsic activities in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b87260cd02b32a5311ee945ad098395
https://doi.org/10.1016/j.neuropharm.2012.08.011

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Novel Cues Reinstate Cocaine-Seeking Behavior and Induce Fos Protein Expression as Effectively as Conditioned Cues

Autor: Peter R. Kufahl, Nathan S. Pentkowski, Janet L. Neisewander, Kenneth J. Thiel, Suzanne M. Weber, Ryan M. Bastle, Mari N Turk

Publikováno v: Neuropsychopharmacology. 37:2109-2120

Cue reinstatement of extinguished cocaine-seeking behavior is a widely used model of cue-elicited craving in abstinent human addicts. This study examined Fos protein expression in response to cocaine cues or to novel cues as a control for activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0646d4a10349a0f38d09ebebcd613b9c
https://doi.org/10.1038/npp.2012.60

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A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model

Autor: David M. Weiner, Francesco Bibbiani, Aiste Kielaite, Suzanne M. Weber, Kimberly E. Vanover, John D. Salamone, Thomas N. Chase, Adrienne J. Betz, Robert E. Davis

Publikováno v: Pharmacology Biochemistry and Behavior. 90:540-544

A potent 5-hydroxytryptamine (5-HT)2A receptor inverse agonist and antagonist, ACP-103 [N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1, active:salt)], was evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9c55ba7868d10634846921a14c2c2d
https://doi.org/10.1016/j.pbb.2008.04.010

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The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors

Autor: John D. Salamone, Peter J. McLaughlin, Suzanne M. Weber, Melissa Burgos, Adrienne J. Betz

Publikováno v: Psychopharmacology. 194:347-359

Nonselective muscarinic acetylcholine antagonists have been used for several years as antiparkinsonian drugs. However, there are at least five subtypes of muscarinic receptor (M1-5). Neostriatal M4 receptors have been implicated in aspects of motor f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ed8155ab078195b164313429d080de
https://doi.org/10.1007/s00213-007-0844-6

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Nucleus Accumbens Dopamine and the Forebrain Circuitry Involved in Behavioral Activation and Effort-Related Decision Making: Implications for Understanding Anergia and Psychomotor Slowing in Depression

Autor: John D. Salamone, Susana Mingote, Mercè Correa, Andrew M. Farrar, Suzanne M. Weber

Publikováno v: Current Psychiatry Reviews. 2:267-280

The notion that motivated behaviors having an energetic or activational component is an old one, and there are numerous examples of this idea from the literatures of psychology and ethology. Behavioral researchers have demonstrated that vigor or pers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71ea79df9c5d5933afc2a1f690c309f5
https://doi.org/10.2174/157340006776875914

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Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine

Autor: Mercè Correa, John D. Salamone, Susana Mingote, Suzanne M. Weber

Publikováno v: Current Opinion in Pharmacology. 5:34-41

According to the dopamine (DA) hypothesis of reward, DA systems in the brain, particularly in the nucleus accumbens, are thought to directly mediate the rewarding or primary motivational characteristics of natural stimuli such as food, water and sex,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0977209edf1233e954c90fd61873afc4
https://doi.org/10.1016/j.coph.2004.09.004

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Effects of 7-OH-DPAT on cocaine-seeking behavior and on re-establishment of cocaine self-administration

Autor: Suzanne M. Weber, Ly T.L. Tran-Nguyen, Rita A. Fuchs, Taline V. Khroyan, Janet L. Neisewander

Publikováno v: Pharmacology Biochemistry and Behavior. 72:623-632

Effects of the D2-like dopamine agonist, 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT), on cocaine-seeking behavior and re-establishment of cocaine self-administration were examined. Rats were trained to lever press for cocaine infusions (0.2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bafc3251d8445f731c54da7556c6f8
https://doi.org/10.1016/s0091-3057(02)00731-1

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A new criterion for acquisition of nicotine self-administration in rats

Autor: Janet L. Neisewander, Kenneth J. Thiel, Suzanne M. Weber, T. H. C. Cheung, Natalie A. Peartree, Federico Sanabria

Publikováno v: Drug and alcohol dependence. 124(1-2)

Acquisition of nicotine self-administration in rodents is relatively difficult to establish and measures of acquisition rate are sometimes confounded by manipulations used to facilitate the process. This study examined acquisition of nicotine self-ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5dad804613671f5ac1bd660564ce42
https://pubmed.ncbi.nlm.nih.gov/22243759

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Stimulation of medial prefrontal cortex serotonin 2C (5-HT(2C)) receptors attenuates cocaine-seeking behavior

Autor: Elizabeth C. Hamilton, Janet L. Neisewander, Lara A. Pockros, Nathan S. Pentkowski, Andrew P. Teer, Felicia D Duke, Kenneth J. Thiel, Suzanne M. Weber

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 35(10)

Serotonin 2C receptor (5-HT(2C)R) agonists administered systemically attenuate both cocaine-primed and cue-elicited reinstatement of extinguished cocaine-seeking behavior. To further elucidate the function of these receptors in addiction-like process

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b04930e468cf742f9dc2acab59e1254
https://pubmed.ncbi.nlm.nih.gov/20948510

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