Výsledky vyhledávání - "Suzanne M. Spong"

Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer

Autor: Brian S. Gloss, David K. Chang, Michael J. Birrer, Samuel Yuen, Carol Wong, Viive M. Howell, Rajmohan Murali, Goli Samimi, Suzanne M. Spong, Laura M. Brown, Neville F. Hacker, Marc D. Jones, Samuel C. Mok, Emily K. Colvin, Sue Ghosh, Christopher J. Scarlett, Kim Moran-Jones

Publikováno v: Oncotarget

Ovarian cancer is the most common cause of death among women with gynecologic cancer. We examined molecular profiles of fibroblasts from normal ovary and high-grade serous ovarian tumors to identify novel therapeutic targets involved in tumor progres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f17ef645daac04b0007ab6cfdcb99c
http://europepmc.org/articles/PMC4792575

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Connective Tissue Growth Factor–Specific Monoclonal Antibody Therapy Inhibits Pancreatic Tumor Growth and Metastasis

Autor: Rendall Nacalumi, Amato J. Giaccia, Michael T. Longaker, Kevin L. Bennewith, Stephen J. Klaus, George P. Yang, Ali Salim, Albert C. Koong, Q.T. Le, Michael Höckel, Carol Wong, Fiona Kaper, Nadja Dornhöfer, Suzanne M. Spong, Neeraja Kambham, Patrick D. Sutphin

Publikováno v: Cancer Research. 66:5816-5827

Pancreatic cancer is highly aggressive and refractory to most existing therapies. Past studies have shown that connective tissue growth factor (CTGF) expression is elevated in human pancreatic adenocarcinomas and some pancreatic cancer cell lines. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22844aed9acff53a91020531ff5c775d
https://doi.org/10.1158/0008-5472.can-06-0081

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Mammalian Tolloid Metalloproteinase, and Not Matrix Metalloprotease 2 or Membrane Type 1 Metalloprotease, Processes Laminin-5 in Keratinocytes and Skin

Autor: Douglas R. Keene, Pasi Nokelainen, Daniel S. Greenspan, N. Nguyen, William N. Pappano, Robert Stephenson, Dallas P. Veitch, Thuong-Thuong Nguyen, Kelly A. McGowan, Suzanne M. Spong, Paul R. Findell, M. Peter Marinkovich

Publikováno v: Journal of Biological Chemistry. 278:15661-15668

Laminin-5, a major adhesive ligand for epithelial cells, undergoes processing of its gamma2 and alpha3 chains. This study investigated the mechanism of laminin-5 processing by keratinocytes. BI-1 (BMP-1 isoenzyme inhibitor-1), a selective inhibitor o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81051454fd8746664ef224b21025d9b2
https://doi.org/10.1074/jbc.m210588200

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CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer

Autor: Kristopher K. Frese, Christian Pilarsky, Todd W. Seeley, Albrecht Neesse, Tashinga E. Bapiro, Mark D. Sternlicht, Suzanne M. Spong, David A. Tuveson, Duncan I. Jodrell, Tomoaki Nakagawa

Publikováno v: Proceedings of the National Academy of Sciences; Vol 110
Proceedings of the National Academy of Sciences

Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant desmoplasia and poor tissue perfusion. These features are proposed to limit the access of therapies to neoplastic cells and blunt treatment efficacy. Indeed, several agents that targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec15ced7338a06331837fb9ad982e91c
https://pubmed.ncbi.nlm.nih.gov/23903094

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CTGF is a therapeutic target for metastatic melanoma

Autor: Erinn B. Rankin, Barbara Bedogni, T. R. Williams, Chao Cheng, Elizabeth C. Finger, Marianne Broome Powell, Suzanne M. Spong, Amato J. Giaccia, Tachiki L

Publikováno v: Oncogene. 33(9)

Metastatic melanoma remains a devastating disease with a 5-year survival rate of less than five percent. Despite recent advances in targeted therapies for melanoma, only a small percentage of melanoma patients experience durable remissions. Therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3942a7caa404447e743effb2fe6d23b
https://pubmed.ncbi.nlm.nih.gov/23435419

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Abstract B33: Inhibition of stromal-derived CTGF sensitizes murine pancreatic adenocarcinoma to gemcitabine treatment

Autor: Kristopher K. Frese, Suzanne M. Spong, Duncan I. Jodrell, Albrecht Neesse, Tash E. Bapiro, David A. Tuveson

Publikováno v: Therapy.

Introduction: Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant desmoplasia contributing to tumor progression and therapeutic resistance. Here, we aim to therapeutically target the profibrotic connective tissue growth factor (CTGF)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::304d77c423227f7195a29dbf5a405998
https://doi.org/10.1158/1538-7445.panca2012-b33

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Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer

Autor: Suzanne M. Spong, Takuma Aikawa, Jason R. Gunn, Murray Korc, Stephen J. Klaus

Publikováno v: Molecular cancer therapeutics. 5(5)

Connective tissue growth factor (CTGF) plays an important role in fibrosis by modulating cell migration and cell growth but may also modify tumor growth and metastasis. Because CTGF is overexpressed in pancreatic ductal adenocarcinoma, we investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24150a9e18e6cca8797078d89fa77346
https://pubmed.ncbi.nlm.nih.gov/16731742

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Mature human thymocytes migrate on laminin-5 with activation of metalloproteinase-14 and cleavage of CD44

Autor: Suzanne M. Spong, Alain Bernard, Patricia Rousselle, Mylène Vivinus-Nebot, Françoise Cottrez, Jean-Philippe Breittmayer, M. Peter Marinkovich, Claire Cenciarini, Sonia Berrih-Aknin, Pasi Nokelainen

Publikováno v: Scopus-Elsevier

We have previously shown that laminin-5 is expressed in the human thymic medulla, in which mature thymocytes are located. We now report that laminin-5 promotes migration of mature medullary thymocytes, whereas it has no effect on cortical immature th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2276d12e991c7a9032de3f257aba50aa
https://pubmed.ncbi.nlm.nih.gov/14734715

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Abstract B58: Connective tissue growth factor (CTGF) as a novel therapeutic target in high grade serous ovarian cancer

Autor: Samuel C. Mok, David K. Chang, Carol Wong, Michael J. Birrer, Kim Moran-Jones, Rajmohan Murali, Neville F. Hacker, Goli Samimi, Suzanne M. Spong

Publikováno v: Clinical Cancer Research. 19:B58-B58

The tumor microenvironment plays an active role in promoting proliferation, invasion and metastasis, thereby making soluble factors secreted by cancer-associated fibroblasts promising therapeutic targets. As a result, secreted tumor stromal factors a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2609b533913206afd35102ed7f313a44
https://doi.org/10.1158/1078-0432.ovca13-b58

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Abstract 509: The CTGF antibody FG-3019 blocks CTGF-stimulated migration in ovarian cancer cells

Autor: Michael J. Birrer, Suzanne M. Spong, Goli Samimi, Carol Wong

Publikováno v: Cancer Research. 71:509-509

Ovarian tumors generally arise from the surface epithelium of the ovary, and require interactions with host stroma to promote tumor cell proliferation and expansion. The signaling mechanisms between tumor-associated stroma and adjacent ovarian epithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::723ec45a90c0698efef47cb6a806be21
https://doi.org/10.1158/1538-7445.am2011-509

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