A study to assess the correlation between plasma, oral fluid and urine concentrations of flunixin meglumine with the tissue residue depletion profile in finishing-age swine

Autor: Jessica L. Bates, Locke A. Karriker, Suzanne M. Rajewski, Zhoumeng Lin, Ronette Gehring, Mengjie Li, Jim E. Riviere, Johann F. Coetzee

Publikováno v: BMC Veterinary Research, Vol 16, Iss 1, Pp 1-13 (2020)

Abstract Background Flunixin meglumine (FM) was investigated for the effectiveness of plasma, oral fluid, and urine concentrations to predict tissue residue depletion profiles in finishing-age swine, along with the potential for untreated pigs to acq

Externí odkaz: https://doaj.org/article/d4418d151c614328a86354a964611bdd

A study to assess the correlation between plasma, oral fluid and urine concentrations of flunixin meglumine with the tissue residue depletion profile in finishing-age swine

Autor: Ronette Gehring, Mengjie Li, Zhoumeng Lin, Locke A. Karriker, Suzanne M. Rajewski, Johann F. Coetzee, Jessica L. Bates, Jim E. Riviere

Publikováno v: BMC Veterinary Research, 16(1). BioMed Central
BMC Veterinary Research, Vol 16, Iss 1, Pp 1-13 (2020)
BMC Veterinary Research

Background Flunixin meglumine (FM) was investigated for the effectiveness of plasma, oral fluid, and urine concentrations to predict tissue residue depletion profiles in finishing-age swine, along with the potential for untreated pigs to acquire tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b440e1bcaabfa102d4d894a7316cdae
https://doi.org/10.1186/s12917-020-02429-w

Variation in water disappearance, daily dose, and synovial fluid concentrations of tylvalosin and 3-O-acetyltylosin in commerical pigs during five day water medication with tylvalosin under field conditions

Autor: Phillip C. Gauger, Johann F. Coetzee, C. Wang, Kristin Skoland, Locke A. Karriker, Paisley Canning, Jessica L. Bates, Suzanne M. Rajewski, L. W. Wulf, Alejandro Ramirez

Publikováno v: Journal of Veterinary Pharmacology and Therapeutics. 41:632-636

Tylvalosin (TVN) is a water soluble macrolide used in swine production to treat enteric, respiratory, and arthritic pathogens. There is limited data on its distribution to synovial fluid beyond gavage studies, which do not represent field conditions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a191798b5af3a3c7c0e0c9257c91a2
https://doi.org/10.1111/jvp.12503

Pharmacokinetics of Ertapenem in Sheep (Ovis aries) with Experimentally Induced Urinary Tract Infection

Autor: Clare C Slagel, Paul J. Plummer, Suzanne M. Rajewski, David J. Borts, Jon P Mochel, Aude A. Ferran, Alain Bousquet-Mélou, Joe S. Smith

Publikováno v: Comparative Medicine
Comparative Medicine, American Association for Laboratory Animal Science, 2019, 69 (5), pp.413-418. ⟨10.30802/AALAS-CM-18-000144⟩

Sheep are commonly used as animal models for human biomedical research, but descriptions of their use for studying the pharmacokinetics of carbapenem antimicrobials, such as ertapenem, are unavailable. Ertapenem is a critical antimicrobial for human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2afbd1d1670111898146081bbab593
https://hal.inrae.fr/hal-02624660

The impact of pain on the pharmacokinetics of transdermal flunixin meglumine administered at the time of cautery dehorning in Holstein calves

Autor: Michael D. Kleinhenz, Patrick J. Gorden, Suzanne M. Rajewski, Nicholas K Van Engen, P. Walsh, Katie E. Kleinhenz, Johann F. Coetzee, Butch KuKanich

Publikováno v: Veterinary anaesthesia and analgesia. 45(6)

Objective To study the influence of pain on the pharmacokinetics and anti-inflammatory actions of transdermal flunixin administered at dehorning. Study design Prospective, crossover, clinical study. Animals A total of 16 male Holstein calves, aged 6�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5eccc93f520a3f4da17aea3a83bf679
https://pubmed.ncbi.nlm.nih.gov/30122634