Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Suzanne M. Pilkington"'
Autor:
Alexandra C. Kendall, Suzanne M. Pilkington, Jonathan R. Wray, Victoria L. Newton, Christopher E. M. Griffiths, Mike Bell, Rachel E. B. Watson, Anna Nicolaou
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The menopause can lead to epidermal changes that are alleviated by hormone replacement therapy (HRT). We hypothesise that these changes could relate to altered ceramide production, and that oestrogen may have a role in keratinocyte ceramide
Externí odkaz:
https://doaj.org/article/82e2ea033c4f431a8e806576b37aa657
Autor:
Emanuel Rognoni, Georgina Goss, Toru Hiratsuka, Kalle H Sipilä, Thomas Kirk, Katharina I Kober, Prudence PokWai Lui, Victoria SK Tsang, Nathan J Hawkshaw, Suzanne M Pilkington, Inchul Cho, Niwa Ali, Lesley E Rhodes, Fiona M Watt
Publikováno v:
eLife, Vol 10 (2021)
Solar ultraviolet radiation (UVR) is a major source of skin damage, resulting in inflammation, premature ageing, and cancer. While several UVR-induced changes, including extracellular matrix reorganisation and epidermal DNA damage, have been document
Externí odkaz:
https://doaj.org/article/4829444af2e143fb9fb4e90ef82c6974
Autor:
Nathan J Hawkshaw, Suzanne M Pilkington, Sharon A Murphy, Norah Al‐Gazaq, Mark D Farrar, Rachel EB Watson, Anna Nicolaou, Lesley E Rhodes
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 4, Pp n/a-n/a (2020)
Abstract Objectives Solar ultraviolet radiation (UVR) has major adverse effects on human health. While the mechanisms responsible for induction of UVR‐induced inflammation are well‐documented, the mediation of its resolution and longer‐term ada
Externí odkaz:
https://doaj.org/article/143eb1fde9084217b2479f8d099fda85
Publikováno v:
Journal of Investigative Dermatology. 141:1087-1095
As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of
Publikováno v:
The British Journal of Dermatology
Summary Background The outbreak of chilblain‐like lesions (CLL) during the COVID‐19 pandemic has been reported extensively, potentially related to SARS‐CoV‐2 infection, yet its underlying pathophysiology is unclear. Objectives To study skin a
Autor:
Katharina Isabelle Kober, Nathan J. Hawkshaw, Georgina Goss, Fiona M. Watt, Prudence PokWai Lui, Inchul Cho, Lesley E. Rhodes, Kalle Sipilä, Niwa Ali, Victoria Sk Tsang, Suzanne M. Pilkington, Toru Hiratsuka, Emanuel Rognoni
Solar ultraviolet radiation (UVR) is a major source of skin damage, resulting in inflammation, premature ageing and cancer. While several UVR-induced changes, including extracellular matrix reorganisation and epidermal DNA damage, have been documente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe8b55ef84bf0fc31c50edf93de949d
https://doi.org/10.1101/2021.06.08.447606
https://doi.org/10.1101/2021.06.08.447606
Autor:
Silvia Bulfone-Paus, Suzanne M. Pilkington, Rachel E.B. Watson, M.J. Barron, Christopher E.M. Griffiths
Publikováno v:
The British Journal of Dermatology
Pilkington, S M, Barron, M J, Watson, R E B, Griffiths, C E M & Bulfone-paus, S 2019, ' Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide-positive nerve fibres ', British Journal of Dermatology, vol. 180, no. 4, pp. 849-858 . https://doi.org/10.1111/bjd.17268
Pilkington, S M, Barron, M J, Watson, R E B, Griffiths, C E M & Bulfone-Paus, S 2019, ' Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide-positive nerve fibres ', British Journal of Dermatology . https://doi.org/10.1111/bjd.17268
Pilkington, S M, Barron, M J, Watson, R E B, Griffiths, C E M & Bulfone-paus, S 2019, ' Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide-positive nerve fibres ', British Journal of Dermatology, vol. 180, no. 4, pp. 849-858 . https://doi.org/10.1111/bjd.17268
Pilkington, S M, Barron, M J, Watson, R E B, Griffiths, C E M & Bulfone-Paus, S 2019, ' Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide-positive nerve fibres ', British Journal of Dermatology . https://doi.org/10.1111/bjd.17268
Summary Background Skin health declines with age and this is partially attributed to immunosenescence. Mast cells (MCs) are innate immune cells that coordinate tissue immune responses integral to skin homeostasis and disease. Objectives To understand
Autor:
Matiss Ozols, Rachel E.B. Watson, Ronan O’Cualain, April Foster, Suzanne M. Pilkington, Christopher E.M. Griffiths, David Knight, Alexander Eckersley, Emma-Jayne Keevill, Michael J. Sherratt
Publikováno v:
Matrix Biology Plus, Vol 5, Iss, Pp-(2020)
Eckersley, A, Ozols, M, O'Cualain, R, Keevill, E-J, Foster, A R, Pilkington, S, Knight, D, Griffiths, CEM, Watson, R & Sherratt, M 2020, ' Proteomic fingerprints of damage in extracellular matrix assemblies ', Matrix Biology Plus . https://doi.org/10.1016/j.mbplus.2020.100027
Matrix Biology Plus
Eckersley, A, Ozols, M, O'Cualain, R, Keevill, E-J, Foster, A R, Pilkington, S, Knight, D, Griffiths, CEM, Watson, R & Sherratt, M 2020, ' Proteomic fingerprints of damage in extracellular matrix assemblies ', Matrix Biology Plus . https://doi.org/10.1016/j.mbplus.2020.100027
Matrix Biology Plus
In contrast to the dynamic intracellular environment, structural extracellular matrix (ECM) proteins with half-lives measured in decades, are susceptible to accumulating damage. Whilst conventional approaches such as histology, immunohistochemistry a
Autor:
Rachel E.B. Watson, Nathan J. Hawkshaw, Lesley E. Rhodes, Sharon Murphy, Suzanne M. Pilkington, Norah Al-Gazaq, Mark D. Farrar, Anna Nicolaou
Publikováno v:
Clinical & Translational Immunology. 9
Objectives Solar ultraviolet radiation (UVR) has major adverse effects on human health. While the mechanisms responsible for induction of UVR-induced inflammation are well-documented, the mediation of its resolution and longer-term adaptive homeostas
Autor:
Suzanne M. Pilkington
Publikováno v:
British Journal of Dermatology. 184:1000-1001