Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Suzanne M. Morris"'
Autor:
Xiaoxia Yang, Suzanne M Morris, Jeffery M Gearhart, Christopher D Ruark, Merle G Paule, William Slikker, Donald R Mattison, Benedetto Vitiello, Nathan C Twaddle, Daniel R Doerge, John F Young, Jeffrey W Fisher
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106101 (2014)
The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development. For the first time a physiologically based pharmacokinetic (PBPK) model has been developed
Externí odkaz:
https://doaj.org/article/b5b645e24fba41e9a37210a41f624b02
Autor:
Daniel A. Casciano, Suzanne M. Morris, Alexandru S. Biris, Andersen Lafont, Thikra Mustafa, Fumiya Watanabe, Vasily N. Dobrovolsky, Dayton M. Petibone, Zeid A. Nima, Shawn E. Bourdo, Alokita Karmakar, Wei Ding
Publikováno v:
Journal of Applied Toxicology. 37:1333-1345
Due to the distinctive physical, electrical, and chemical properties of graphene nanomaterials, numerous efforts pursuing graphene-based biomedical and industrial applications are underway. Oxidation of pristine graphene surfaces mitigates its otherw
Autor:
Rosemary Roberts, Gonçalo Gamboa da Costa, Suzanne M. Morris, Lucie Loukotková, Mallikarjuna S. Basavarajappa, Jeffrey W. Fisher, Annie Lumen, Frederick A. Beland, Donald R. Mattison
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 112
Oseltamivir is an antiviral drug approved to treat influenza in humans. Although the dosing regimen of this drug is well established for non-pregnant patients, it is not clear if the significant physiological alterations associated with pregnancy aff
Autor:
Suzanne M. Morris, Vasily N. Dobrovolsky, Bridgett Knox, Javier R. Revollo, Dayton M. Petibone, Page B. McKinzie, Baitang Ning
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 795:60-69
Closely related TK6, WTK1, and NH32 human B-lymphoblastoid cell lines differ in their p53 functional status. These lines are used frequently in genotoxicity studies and in studies aimed at understanding the role of p53 in DNA repair. Despite their ro
Autor:
Dayton M, Petibone, Thikra, Mustafa, Shawn E, Bourdo, Andersen, Lafont, Wei, Ding, Alokita, Karmakar, Zeid A, Nima, Fumiya, Watanabe, Daniel, Casciano, Suzanne M, Morris, Vasily N, Dobrovolsky, Alexandru S, Biris
Publikováno v:
Journal of applied toxicology : JAT. 37(11)
Due to the distinctive physical, electrical, and chemical properties of graphene nanomaterials, numerous efforts pursuing graphene-based biomedical and industrial applications are underway. Oxidation of pristine graphene surfaces mitigates its otherw
Autor:
Mallikarjuna S. Basavarajappa, Donald R. Mattison, Denita Williams, Suzanne M. Morris, Sonja A. Rasmussen
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 100:806-810
The U.S. Food and Drug Administration (FDA) and other federal agencies partner to ensure that medical countermeasures (e.g., drug therapies and vaccines) are available for public health emergencies (FDA, 2014). Despite continuing progress, providing
Autor:
Suzanne M. Morris, Donald R. Mattison, James J. Chen, Kristine L. Witt, Dayton M. Petibone, Wei Jiun Lin, Benedetto Vitiello
Publikováno v:
Journal of Applied Toxicology. 32:756-764
Attention deficit/hyperactivity disorder (ADHD), a common children's behavioral disorder, is characterized by inattention, hyperactivity and impulsivity. The disorder is thought to stem from abnormalities in the catecholamine pathway and the symptoms
Autor:
Donald R. Mattison, Charlotte E. Hotchkiss, Merle G. Paule, Suzanne M. Morris, Daniel R. Doerge, R.R. Allen, Jesse S. Rodriguez
Publikováno v:
Neurotoxicology and Teratology. 32:142-151
Methylphenidate (MPH) is an amphetamine derivative widely prescribed for the treatment of attention deficit–hyperactivity disorder. Recent concern over its genotoxic potential in children [11] spurred a study on the effects of chronic MPH treatment
Autor:
Makoto Uchikawa, Donald R. Mattison, Vasily N. Dobrovolsky, Mugimane G. Manjanatha, Daishiro Miura, Roberta A. Mittelstaedt, Joseph G. Shaddock, Suzanne M. Morris
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 673:21-28
We have investigated the use of peripheral blood from the nonhuman primate (NHP) rhesus monkey (Macaca mulatta) as a model system for mutation detection. The rhesus monkey is metabolically closer to humans than most common laboratory animals, and the
Autor:
Donald R. Mattison, Vasily N. Dobrovolsky, Joseph G. Shaddock, Charlotte E. Hotchkiss, Mugimane G. Manjanatha, James J. Chen, Merle G. Paule, Daniel R. Doerge, Roberta A. Mittelstaedt, Sharon D. Shelton, Dayton M. Petibone, William Slikker, Chien-Ju Lin, Michelle E. Bishop, Suzanne M. Morris, James D. Tucker, Nathan C. Twaddle
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 673:59-66
The studies presented in this work were designed to evaluate the genetic toxicity of methylphenidate hydrochloride (MPH) in non-human primates (NHP) using a long-term, chronic dosing regimen. Thus, approximately two-year old, male rhesus monkeys of I