Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry

Autor: Kamalakannan Vijayan, Igor Cestari, Fred D. Mast, Elizabeth K.K. Glennon, Suzanne M. McDermott, Heather S. Kain, Alyssa M. Brokaw, John D. Aitchison, Kenneth Stuart, Alexis Kaushansky

Publikováno v: iScience, Vol 21, Iss , Pp 603-611 (2019)

Summary: The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes, lysosomes are redistributed away from the nucleus, and surface exposure of lysosome-

Externí odkaz: https://doaj.org/article/71883b55b11447df94c7c0940ad75586

Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification

Autor: Suzanne M. McDermott, Carine Meignin, Juri Rappsilber, Ilan Davis

Publikováno v: Biology Open, Vol 1, Iss 5, Pp 488-497 (2012)

Summary In the Drosophila oocyte, mRNA transport and localised translation play a fundamental role in axis determination and germline formation of the future embryo. gurken mRNA encodes a secreted TGF-α signal that specifies dorsal structures, and i

Externí odkaz: https://doaj.org/article/2cf15b9d93b64c938db1174521559772

Trypanosome RNA helicase KREH2 differentially controls noncanonical editing and putative repressive structure via a novel proposed 'bifunctional' gRNA in mRNA A6

Autor: Joshua Meehan, Suzanne M McDermott, Alasdair Ivens, Zachary Goodall, Zihao Chen, Zihao Yu, Jia Woo, Tyler Rodshagen, Laura McCleskey, Rebecca Sechrist, Kenneth Stuart, Lanying Zeng, Silvi Rouskin, Nicholas J Savill, Achim Schnaufer, Xiuren Zhang, Jorge Cruz-Reyes

Publikováno v: Meehan, J, McDermott, S M, Ivens, A, Goodall, Z, Chen, Z, Yu, Z, Woo, J, Rodshagen, T, McCleskey, L, Seachrist, R, Stuart, K D, Zeng, L, Rouskin, S, Savill, N J, Schnaufer, A, Zhang, X & Cruz-Reyes, J 2023, ' Trypanosome RNA helicase KREH2 differentially controls noncanonical editing and putative repressive structure via a novel proposed “bifunctional” gRNA in mRNA A6 ', NAR Genomics and Bioinformatics . https://doi.org/10.1093/nar/gkad453

U-insertion/deletion (U-indel) RNA editing in trypanosome mitochondria is directed by guide RNAs (gRNAs). This editing may developmentally control respiration in bloodstream forms (BSF) and insect procyclic forms (PCF). Holo-editosomes include the ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68bf9857675bb3b3d84828313abec39
https://www.pure.ed.ac.uk/ws/files/353452655/gkad453.pdf

mt-LAF3 is a pseudouridine synthase ortholog required for mitochondrial rRNA and mRNA gene expression in Trypanosoma brucei

Autor: Suzanne M McDermott, Vy Pham, Isaac Lewis, Maxwell Tracy, Kenneth Stuart

Publikováno v: bioRxiv

Trypanosoma bruceiand related kinetoplastid parasites possess unique RNA processing pathways, including in their mitochondria, that regulate metabolism and development. Altering RNA composition or conformation through nucleotide modifications is one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9ee5fc6aab83cce7091cf1e8078de2
https://europepmc.org/articles/PMC9980140/

Domain function and predicted structure of three heterodimeric endonuclease subunits of RNA editing catalytic complexes in Trypanosoma brucei

Autor: Jason Carnes, Suzanne M McDermott, Isaac Lewis, Maxwell Tracy, Kenneth Stuart

Publikováno v: Nucleic acids research. 50(17)

Each of the three similar RNA Editing Catalytic Complexes (RECCs) that perform gRNA-directed uridine insertion and deletion during Trypanosoma brucei mitochondrial (mt) mRNA editing has a distinct endonuclease activity that requires two related RNase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4577b96547f0573ffa271713a96f62b9
https://pubmed.ncbi.nlm.nih.gov/36095119