Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge.

Autor: Damian A Oyong, Fergal J Duffy, Maxwell L Neal, Ying Du, Jason Carnes, Katharine V Schwedhelm, Nina Hertoghs, Seong-Hwan Jun, Helen Miller, John D Aitchison, Stephen C De Rosa, Evan W Newell, M Juliana McElrath, Suzanne M McDermott, Kenneth D Stuart

Publikováno v: PLoS Pathogens, Vol 19, Iss 5, p e1011051 (2023)

Understanding immune mechanisms that mediate malaria protection is critical for improving vaccine development. Vaccination with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) induces high level of sterilizing immunity against malaria

Externí odkaz: https://doaj.org/article/5e95f5d58ff341c091cc9cbb0bcf49d6

Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry

Autor: Kamalakannan Vijayan, Igor Cestari, Fred D. Mast, Elizabeth K.K. Glennon, Suzanne M. McDermott, Heather S. Kain, Alyssa M. Brokaw, John D. Aitchison, Kenneth Stuart, Alexis Kaushansky

Publikováno v: iScience, Vol 21, Iss , Pp 603-611 (2019)

Summary: The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes, lysosomes are redistributed away from the nucleus, and surface exposure of lysosome-

Externí odkaz: https://doaj.org/article/71883b55b11447df94c7c0940ad75586

Trypanosome RNA helicase KREH2 differentially controls noncanonical editing and putative repressive structure via a novel proposed 'bifunctional' gRNA in mRNA A6

Autor: Joshua Meehan, Suzanne M McDermott, Alasdair Ivens, Zachary Goodall, Zihao Chen, Zihao Yu, Jia Woo, Tyler Rodshagen, Laura McCleskey, Rebecca Sechrist, Kenneth Stuart, Lanying Zeng, Silvi Rouskin, Nicholas J Savill, Achim Schnaufer, Xiuren Zhang, Jorge Cruz-Reyes

Publikováno v: Meehan, J, McDermott, S M, Ivens, A, Goodall, Z, Chen, Z, Yu, Z, Woo, J, Rodshagen, T, McCleskey, L, Seachrist, R, Stuart, K D, Zeng, L, Rouskin, S, Savill, N J, Schnaufer, A, Zhang, X & Cruz-Reyes, J 2023, ' Trypanosome RNA helicase KREH2 differentially controls noncanonical editing and putative repressive structure via a novel proposed “bifunctional” gRNA in mRNA A6 ', NAR Genomics and Bioinformatics . https://doi.org/10.1093/nar/gkad453

U-insertion/deletion (U-indel) RNA editing in trypanosome mitochondria is directed by guide RNAs (gRNAs). This editing may developmentally control respiration in bloodstream forms (BSF) and insect procyclic forms (PCF). Holo-editosomes include the ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68bf9857675bb3b3d84828313abec39
https://www.pure.ed.ac.uk/ws/files/353452655/gkad453.pdf

mt-LAF3 is a pseudouridine synthase ortholog required for mitochondrial rRNA and mRNA gene expression in Trypanosoma brucei

Autor: Suzanne M McDermott, Vy Pham, Isaac Lewis, Maxwell Tracy, Kenneth Stuart

Publikováno v: bioRxiv

Trypanosoma bruceiand related kinetoplastid parasites possess unique RNA processing pathways, including in their mitochondria, that regulate metabolism and development. Altering RNA composition or conformation through nucleotide modifications is one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9ee5fc6aab83cce7091cf1e8078de2
https://europepmc.org/articles/PMC9980140/

RNase III Domain of KREPB9 and KREPB10 Association with Editosomes in Trypanosoma brucei

Autor: Jason Carnes, Suzanne M. McDermott, Kenneth Stuart

Publikováno v: mSphere, Vol 3, Iss 1 (2018)

ABSTRACT Editosomes are the multiprotein complexes that catalyze the insertion and deletion of uridines to create translatable mRNAs in the mitochondria of kinetoplastids. Recognition and cleavage of a broad diversity of RNA substrates in vivo requir

Externí odkaz: https://doaj.org/article/ee24059b884847dbb972ed5ed619f950