Výsledky vyhledávání - "Suzanne M. Hickerson"

Inositol phosphorlyceramide synthase null Leishmania major are viable and virulent in animal infections where salvage of host sphingomyelin predominates

Autor: F. Matthew Kuhlmann, Phillip N. Key, Suzanne M. Hickerson, John Turk, Fong-Fu Hsu, Stephen M. Beverley

Many pathogens synthesize inositolphosphorylceramide (IPC) as the major sphingolipid (SL), differing from the mammalian host where sphingomyelin (SM) or more complex SLs predominate, and the divergence between IPCS and mammalian sphingolipid synthase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4e9af684edeed28e3c6a78412ce5079
https://doi.org/10.1101/2022.06.14.496188

Zobrazit plný text záznamu

Akademický článek

Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A.

Autor: Mary-Anne Hartley, Eliane Bourreau, Matteo Rossi, Patrik Castiglioni, Remzi Onur Eren, Florence Prevel, Pierre Couppié, Suzanne M Hickerson, Pascal Launois, Stephen M Beverley, Catherine Ronet, Nicolas Fasel

Publikováno v: PLoS Pathogens, Vol 12, Iss 9, p e1005852 (2016)

Cutaneous leishmaniasis has various outcomes, ranging from self-healing reddened papules to extensive open ulcerations that metastasise to secondary sites and are often resistant to standard therapies. In the case of L. guyanensis (L.g), about 5-10%

Externí odkaz: https://doaj.org/article/0a44ffda5fb54cbb8624a4f7be6a9e16

Zobrazit plný text záznamu

Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response

Autor: F. Matthew Kuhlmann, Nicolas Fasel, Jahangheer S. Shaik, Suzanne M. Hickerson, Stephen M. Beverley, Haroun Zangger, Lon-Fye Lye, Erin A. Brettmann, Katherine Owens, Natalia S. Akopyants, Catherine Ronet, Dayna M. Oschwald

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 43, pp. 11998-12005

Many Leishmania (Viannia) parasites harbor the double-stranded RNA virus Leishmania RNA virus 1 (LRV1), which has been associated with increased disease severity in animal models and humans and with drug treatment failures in humans. Remarkably, LRV1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38901f3493f223efa5bc8b27ca72304
http://www.pnas.org/content/113/43/11998.long

Zobrazit plný text záznamu

Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells

Autor: Nicholas S. Geraci, Suzanne M. Hickerson, Mary Ann McDowell, Michelle A. Favila, Janet Mostrom, Salvatore J. Turco, Stephen M. Beverley, Asha Jayakumar

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 12, p e0004238 (2015)
PLoS Neglected Tropical Diseases

Background Leishmania major infection induces robust interleukin-12 (IL12) production in human dendritic cells (hDC), ultimately resulting in Th1-mediated immunity and clinical resolution. The surface of Leishmania parasites is covered in a dense gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3d2379afb9899d1e0591b4828cbc27
http://europepmc.org/articles/PMC4667916?pdf=render

Zobrazit plný text záznamu

Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice

Autor: Melissa Showalter, Rafael Balaña-Fouce, Suzanne M. Hickerson, Rosa M. Reguera, Stephen M. Beverley

Publikováno v: Molecular and Biochemical Parasitology. 165:48-56

Polyamines are essential metabolites in eukaryotes participating in a variety of proliferative processes, and in trypanosomatid protozoa play an additional role in the synthesis of the critical thiol trypanothione. Whereas the polyamine biosynthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b3bc6955d2b23155c749bc509678bc
https://doi.org/10.1016/j.molbiopara.2009.01.001

Zobrazit plný text záznamu

Comparisons of Mutants Lacking the Golgi UDP-Galactose or GDP-Mannose Transporters Establish that Phosphoglycans Are Important for Promastigote but Not Amastigote Virulence in Leishmania major

Autor: Suzanne M. Hickerson, Althea A. Capul, Stephen M. Beverley, Tamara Barron, Salvatore J. Turco

Publikováno v: Infection and Immunity. 75:4629-4637

Abundant surface Leishmania phosphoglycans (PGs) containing [Gal(β1,4)Man(α1-PO 4 )]-derived repeating units are important at several points in the infectious cycle of this protozoan parasite. PG synthesis requires transport of activated nucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcf89ceb6677129ddb8b61c0bcd00c9
https://doi.org/10.1128/iai.00735-07

Zobrazit plný text záznamu

Localization of IFN-γ-Activated Stat1 and IFN Regulatory Factors 1 and 2 in Breast Cancer Cells

Autor: Suzanne M. Hickerson, Gerard M. Doherty, Judith M. Connett, Susan J. Wu, Steven R. Hunt

Publikováno v: Journal of Interferon & Cytokine Research. 23:621-630

The aim of the present work was to evaluate the induction and localization of Stat1, interferon (IFN) regulatory factor-1 (IRF-1), and IRF-2 after IFN-gamma exposure of human breast cancer cell lines, SKBR3, MDA468, MCF7, and BT20. Results from growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2790195333e50e043ed779e03d953c
https://doi.org/10.1089/107999003322558755

Zobrazit plný text záznamu

Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A

Autor: Remzi Onur Eren, Florence Prevel, Nicolas Fasel, Matteo Rossi, Pierre Couppié, Pascal Launois, Stephen M. Beverley, Suzanne M. Hickerson, Mary-Anne Hartley, Eliane Bourreau, Catherine Ronet, Patrik Castiglioni

Publikováno v: Plos Pathogens
PLoS Pathogens
PLOS Pathogens
PLoS Pathogens, vol. 12, no. 9, pp. e1005852
PLoS Pathogens, Vol 12, Iss 9, p e1005852 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea14ee817b117bd2baadd413eb5283c
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005852

Zobrazit plný text záznamu

Killed but metabolically active Leishmania infantum as a novel whole-cell vaccine for visceral leishmaniasis

Autor: Ron Birnbaum, Stephen M. Beverley, Kevin W. Bruhn, Mary E. Wilson, Thu Anh Tran, Suzanne M. Hickerson, Jacquelyn Haskell, Noah Craft, Stephanie Greger, Rupa Narayan, Pei-Lin Chang, Veena Vanchinathan

Publikováno v: Clinical and vaccine immunology : CVI. 19(4)

There are currently no effective vaccines for visceral leishmaniasis, the second most deadly parasitic infection in the world. Here, we describe a novel whole-cell vaccine approach usingLeishmania infantum chagasipromastigotes treated with the psoral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b00cd7c3f51c37d25e96c3ef533240e
https://pubmed.ncbi.nlm.nih.gov/22913255

Zobrazit plný text záznamu

Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis

Autor: Stephen M. Beverley, Silvia A. Fuertes-Marraco, Lon-Fye Lye, Giulia Ruzzante, Mélanie Revaz-Breton, Suzanne M. Hickerson, Haroun Zangger, Florence Prevel, Catherine Ronet, Nicolas Fasel, Slavica Masina, Pascal Launois, Frédéric Schütz, Hans Acha-Orbea, Annette Ives

Publikováno v: Science, vol. 331, no. 6018, pp. 775-778
Science (New York N.Y.)

Mucocutaneous leishmaniasis is caused by infections with intracellular parasites of the Leishmania Viannia subgenus, including Leishmania guyanensis. The pathology develops after parasite dissemination to nasopharyngeal tissues, where destructive met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b798ff98dc10c23a73df16225357c2b5
https://serval.unil.ch/notice/serval:BIB_8FAE2070D6E0

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání