Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Suzanne M. Bock"'
Autor:
Russell F. Ross, Tejal A. Desai, Jubin Ryu, Theodora M. Mauro, Suzanne M. Bock, Michael Koval, Laura A. Walsh
Publikováno v:
Nano Letters. 15:2434-2441
Transdermal delivery of therapeutics is restricted by narrow limitations on size and hydrophobicity. Nanotopography has been shown to significantly enhance high molecular weight paracellular transport in vitro. Herein, we demonstrate for the first ti
Autor:
Tejal A. Desai, William T. Koval, Samuel A. Molina, James W. Lillard, Michael Koval, Tarianna Stewart, Suzanne M. Bock, Russell F. Ross
Publikováno v:
Experimental cell research, vol 355, iss 2
Transport of therapeutic agents across epithelial barriers is an important element in drug delivery. Transepithelial flux is widely used as a measure of transit across an epithelium, however it is most typically employed as a relative as opposed to a
Autor:
Russell F. Ross, Suzanne M. Bock, Jeremy Ollerenshaw, Tarianna Hutto, James W. Lillard, Snehasikta Swarnakar, Michael Koval
Publikováno v:
The FASEB Journal. 28
Paracellular permeability between epithelial cells is regulated by tight junctions (TJs) which act as a barrier to drug delivery across the epithelium. Previous studies (Kam et al., Nano Lett. (201...
Autor:
Russell F. Ross, Kathleen E. Fischer, Tejal A. Desai, Michael Koval, Laura A. Walsh, Kimberly R. Kam, Suzanne M. Bock
Publikováno v:
Nano letters. 13(1)
Herein, we demonstrate that nanotopographical cues can be utilized to enable biologics >66 kDa to be transported across epithelial monolayers. When placed in contact with epithelial monolayers, nanostructured thin films loosen the epithelial barrier