Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Suzanne M McDermott"'
Autor:
Damian A Oyong, Fergal J Duffy, Maxwell L Neal, Ying Du, Jason Carnes, Katharine V Schwedhelm, Nina Hertoghs, Seong-Hwan Jun, Helen Miller, John D Aitchison, Stephen C De Rosa, Evan W Newell, M Juliana McElrath, Suzanne M McDermott, Kenneth D Stuart
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011051 (2023)
Understanding immune mechanisms that mediate malaria protection is critical for improving vaccine development. Vaccination with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) induces high level of sterilizing immunity against malaria
Externí odkaz:
https://doaj.org/article/5e95f5d58ff341c091cc9cbb0bcf49d6
Autor:
Ying Du, Nina Hertoghs, Fergal J Duffy, Jason Carnes, Suzanne M McDermott, Maxwell L Neal, Katharine V Schwedhelm, M Juliana McElrath, Stephen C De Rosa, John D Aitchison, Kenneth D Stuart
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010282 (2022)
Immunization with radiation-attenuated sporozoites (RAS) can confer sterilizing protection against malaria, although the mechanisms behind this protection are incompletely understood. We performed a systems biology analysis of samples from the Immuni
Externí odkaz:
https://doaj.org/article/6c701424a6214177b0d5fae85a2fb05a
Autor:
Jason Carnes, Atashi Anupama, Oliver Balmer, Andrew Jackson, Michael Lewis, Rob Brown, Igor Cestari, Marc Desquesnes, Claire Gendrin, Christiane Hertz-Fowler, Hideo Imamura, Alasdair Ivens, Luděk Kořený, De-Hua Lai, Annette MacLeod, Suzanne M McDermott, Chris Merritt, Severine Monnerat, Wonjong Moon, Peter Myler, Isabelle Phan, Gowthaman Ramasamy, Dhileep Sivam, Zhao-Rong Lun, Julius Lukeš, Ken Stuart, Achim Schnaufer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e3404 (2015)
Two key biological features distinguish Trypanosoma evansi from the T. brucei group: independence from the tsetse fly as obligatory vector, and independence from the need for functional mitochondrial DNA (kinetoplast or kDNA). In an effort to better
Externí odkaz:
https://doaj.org/article/d09946f575ea4622a4e33eb7a7d8ce64
Autor:
Suzanne M McDermott, Ilan Davis
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69978 (2013)
In the Drosophila oocyte, gurken (grk) mRNA encodes a secreted TGF-α signal that specifies the future embryonic dorso-ventral axes by altering the fate of the surrounding epithelial follicle cells. We previously identified a number of RNA binding pr
Externí odkaz:
https://doaj.org/article/fba757c160304d879a499fba4c7d822c
Publikováno v:
RNA. 29:228-240
Mitochondrial gene expression in trypanosomes requires numerous multiprotein complexes that are unique to kinetoplastids. Among these, the most well characterized are RNA editing catalytic complexes (RECCs) that catalyze the guide RNA (gRNA)-specifie
Autor:
Joshua Meehan, Suzanne M McDermott, Alasdair Ivens, Zachary Goodall, Zihao Chen, Zihao Yu, Jia Woo, Tyler Rodshagen, Laura McCleskey, Rebecca Sechrist, Kenneth Stuart, Lanying Zeng, Silvi Rouskin, Nicholas J Savill, Achim Schnaufer, Xiuren Zhang, Jorge Cruz-Reyes
Publikováno v:
Meehan, J, McDermott, S M, Ivens, A, Goodall, Z, Chen, Z, Yu, Z, Woo, J, Rodshagen, T, McCleskey, L, Seachrist, R, Stuart, K D, Zeng, L, Rouskin, S, Savill, N J, Schnaufer, A, Zhang, X & Cruz-Reyes, J 2023, ' Trypanosome RNA helicase KREH2 differentially controls noncanonical editing and putative repressive structure via a novel proposed “bifunctional” gRNA in mRNA A6 ', NAR Genomics and Bioinformatics . https://doi.org/10.1093/nar/gkad453
U-insertion/deletion (U-indel) RNA editing in trypanosome mitochondria is directed by guide RNAs (gRNAs). This editing may developmentally control respiration in bloodstream forms (BSF) and insect procyclic forms (PCF). Holo-editosomes include the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68bf9857675bb3b3d84828313abec39
https://www.pure.ed.ac.uk/ws/files/353452655/gkad453.pdf
https://www.pure.ed.ac.uk/ws/files/353452655/gkad453.pdf
Autor:
Brittney Davidge, Suzanne M McDermott, Jason Carnes, Isaac Lewis, Maxwell Tracy, Kenneth D. Stuart
Publikováno v:
bioRxiv
The gRNA directed U-insertion and deletion editing of mitochondrial mRNAs that is essential in different life cycle stages for the protozoan parasiteTrypanosoma bruceiis performed by three similar multi-protein catalytic complexes (CCs) that contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ceac94ce7c1b8a24855985e6b8926b
https://europepmc.org/articles/PMC10153193/
https://europepmc.org/articles/PMC10153193/
Publikováno v:
bioRxiv
Trypanosoma bruceiand related kinetoplastid parasites possess unique RNA processing pathways, including in their mitochondria, that regulate metabolism and development. Altering RNA composition or conformation through nucleotide modifications is one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9ee5fc6aab83cce7091cf1e8078de2
https://europepmc.org/articles/PMC9980140/
https://europepmc.org/articles/PMC9980140/
Autor:
Damian A Oyong, Fergal J Duffy, Maxwell L Neal, Ying Du, Jason Carnes, Katharine V Schwedhelm, Nina Hertoghs, Seong-Hwan Jun, Helen Miller, John D Aitchison, Stephen C De Rosa, Evan W Newell, M Juliana McElrath, Suzanne M McDermott, Kenneth D Stuart
Understanding immune mechanisms that mediate malaria protection is critical for improving vaccine development. Vaccination with radiation-attenuatedPlasmodium falciparumsporozoites (PfRAS) induces high level of sterilizing immunity against malaria an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7a30050acd8d6f2752f2d9d23d3eff
https://doi.org/10.1101/2022.12.09.519706
https://doi.org/10.1101/2022.12.09.519706
Publikováno v:
Nucleic acids research. 50(17)
Each of the three similar RNA Editing Catalytic Complexes (RECCs) that perform gRNA-directed uridine insertion and deletion during Trypanosoma brucei mitochondrial (mt) mRNA editing has a distinct endonuclease activity that requires two related RNase