Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Suzanne M Appleyard"'
Autor:
Damien eGuimond, Diabe eDiabira, Christophe ePorcher, Francesca eBader, Nadine eFerrand, Mingyan eZhu, Suzanne M Appleyard, Gary A Wayman, Jean-luc eGaiarsa
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
It is becoming increasingly clear that leptin is not only a hormone regulating energy homeostasis but also a neurotrophic factor impacting a number of brain regions, including the hippocampus. Although leptin promotes the development of GABAergic tra
Externí odkaz:
https://doaj.org/article/b5da3606a9764a8995e283963df9cb0e
Autor:
Adam Lesiak, Carl Pelz, Hideaki Ando, Mingyan Zhu, Monika Davare, Talley J Lambert, Katelin F Hansen, Karl Obrietan, Suzanne M Appleyard, Soren Impey, Gary A Wayman
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e64658 (2013)
Neurotrophin-regulated gene expression is believed to play a key role in long-term changes in synaptic structure and the formation of dendritic spines. Brain-derived neurotrophic factor (BDNF) has been shown to induce increases in dendritic spine for
Externí odkaz:
https://doaj.org/article/a3c8cf67529047d79eb49e6cf3031e8d
Autor:
Soren Impey, Tyler Bland, Suzanne M. Appleyard, Crystal Dillon, Gulcan Semra Sahin, Gary A. Wayman, Mingyan Zhu
Publikováno v:
Endocrinology
Leptin has neurotrophic actions in the hippocampus to increase synapse formation and stimulate neuronal plasticity. Leptin also enhances cognition and has antidepressive and anxiolytic-like effects, two hippocampal-dependent behaviors. In contrast, m
Autor:
Mingyan Zhu, Elana Henning, Beata K. Blaszczyk, Julia M. Keogh, Gary A. Wayman, Takuhiro Sonoyama, Peter Kirwan, Suzanne M. Appleyard, Magdalena Jura, Inês Barroso, I. Sadaf Farooqi, Bas Brouwers, Florian T. Merkle, Marko Hyvönen, David C. DeWitt, Lukas K. J. Stadler, Fuki M. Hisama
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation and plasticity. In rodents, genetic disruption of Bdnf and TrkB leads to weig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddd268bbaac5938f458eea7a20b0c87
https://www.repository.cam.ac.uk/handle/1810/323400
https://www.repository.cam.ac.uk/handle/1810/323400
Autor:
Suzanne M. Appleyard, Jose Luis Rodriguez-Llamas, Tyler Bland, Crystal Dillon, Gulcan Semra Sahin, Mingyan Zhu, Gary A. Wayman
Publikováno v:
Endocrinology
Activation of the leptin receptor, LepRb, by the adipocytokine/neurotrophic factor leptin in the central nervous system has procognitive and antidepressive effects. Leptin has been shown to increase glutamatergic synaptogenesis in multiple brain regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b40a07457f5315186c88031f5ab60ce
https://europepmc.org/articles/PMC7015580/
https://europepmc.org/articles/PMC7015580/
Autor:
Mingyan Zhu, Gary A. Wayman, Soren Impey, Crystal Dillon, Talley J. Lambert, Gulcan Semra Sahin, Suzanne M. Appleyard, Hiroko Shiina, Matasha Dhar, Bradley D. Winters
Publikováno v:
Mol Cell Neurosci
Normal development of neuronal connections in the hippocampus requires neurotrophic signals, including the cytokine leptin. During neonatal development, leptin induces formation and maturation of dendritic spines, the main sites of glutamatergic syna
Autor:
Gary A. Wayman, Drew Neyens, Robert C. Ritter, Huan Zhao, Suzanne M. Appleyard, Nathaneal J. Huston
Publikováno v:
J Neurosci
Leptin signaling within the nucleus of the solitary tract (NTS) contributes to the control of food intake, and injections of leptin into the NTS reduce meal size and increase the efficacy of vagus-mediated satiation signals. Leptin receptors (LepRs)
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 316(1)
Nicotine is an addictive drug that has broad effects throughout the brain. One site of action is the nucleus of the solitary tract (NTS), where nicotine initiates a stress response and modulates cardiovascular and gastric function through nicotinic a
Autor:
Suzanne M. Appleyard, Benjamin W. Thompson, Mingyan Zhu, Jacqueline M. Ho, James E. Blevins, Bang H. Hwang, Denis G. Baskin, Vishwanath T. Anekonda, R. W. Curry, Michael W. Schwartz, Gregory J. Morton
Publikováno v:
Endocrinology. 155:2845-2857
Oxytocin (OT)-elicited hypophagia has been linked to neural activity in the nucleus of the solitary tract (NTS). Because plasma OT levels increase after a meal, we hypothesized that circulating OT acts at both peripheral and hindbrain OT receptors (O
Autor:
Gary A. Wayman, Suzanne M. Appleyard, Soren Impey, Matasha Dhar, Tyler Bland, Ilia N. Karatsoreos, Takanobu Nakazawa, Talley J. Lambert, Mingyan Zhu
Publikováno v:
Molecular Endocrinology. 28:1073-1087
Leptin acts in the hippocampus to enhance cognition and reduce depression and anxiety. Cognitive and emotional disorders are associated with abnormal hippocampal dendritic spine formation and synaptogenesis. Although leptin has been shown to induce s