Výsledky vyhledávání - "Suzanne M, Lohmann"

Thrombin and Collagen Induce a Feedback Inhibitory Signaling Pathway in Platelets Involving Dissociation of the Catalytic Subunit of Protein Kinase A from an NFκB-IκB Complex

Autor: Sabine Herterich, Natalia Rukoyatkina, Stepan Gambaryan, Joerg Geiger, Suzanne M. Lohmann, Ulrich Walter, Anna Kobsar, Albert Smolenski

Publikováno v: Journal of Biological Chemistry. 285:18352-18363

Protein kinase A (PKA) activation by cAMP phosphorylates multiple target proteins in numerous platelet inhibitory pathways that have a very important role in maintaining circulating platelets in a resting state. Here we show that in thrombin- and col

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6f9cfdefe5c170a25253578c34a6b1
https://doi.org/10.1074/jbc.m109.077602

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cGMP-dependent Protein Kinase Type I Inhibits TAB1-p38 Mitogen-activated Protein Kinase Apoptosis Signaling in Cardiac Myocytes

Autor: Christian Willenbockel, Helmut Drexler, Franz Hofmann, Suzanne M. Lohmann, Kai C. Wollert, Robert Feil, Beate Fiedler, Albert Smolenski

Publikováno v: Journal of Biological Chemistry. 281:32831-32840

Cardiac myocyte apoptosis during ischemia and reperfusion (I/R) is tightly controlled by a complex network of stress-responsive signaling pathways. One pro-apoptotic pathway involves the interaction of the scaffold protein TAB1 with p38 mitogen-activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ffc1142112ca30e60747406e55a942
https://doi.org/10.1074/jbc.m603416200

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A Sensitive Method for Determining the Phosphorylation Status of Natriuretic Peptide Receptors: cGK-Iα Does Not Regulate NPR-A

Autor: Susanne Feil, Lincoln Ross Potter, Paula M. Bryan, Dmitri Smirnov, Suzanne M Lohmann, Robert Feil, Franz Hofmann, Albert Smolenski

Publikováno v: Biochemistry. 45:1295-1303

Natriuretic peptide receptor A (NPR-A) and natriuretic peptide receptor B (NPR-B) are transmembrane guanylyl cyclases that catalyze the synthesis of cGMP in response to natriuretic peptides. Phosphorylation and dephosphorylation regulate these recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c17437df2b897eb76c525271f346e2
https://doi.org/10.1021/bi051253d

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Presynaptic and Postsynaptic Roles of NO, cGK, and RhoA in Long-Lasting Potentiation and Aggregation of Synaptic Proteins

Autor: Jan de Vente, Hong-Gang Wang, Ulrich Walter, Robert D. Hawkins, Eric R. Kandel, Hiroshi Udo, Iksung Jin, Irina Antonova, Fang Min Lu, Suzanne M. Lohmann

Publikováno v: Neuron. 45(3):389-403

SummaryRecent results suggest that long-lasting potentiation at hippocampal synapses involves the rapid formation of clusters or puncta of presynaptic as well as postsynaptic proteins, both of which are blocked by antagonists of NMDA receptors and an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3a3d5c46cab017b515ffaa8239f63d

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MKP-1 expression and stabilization and cGK Iα prevent diabetes- associated abnormalities in VSMC migration

Autor: Najma Begum, Suzanne M. Lohmann, Asha Jacob, Albert Smolenski

Publikováno v: American Journal of Physiology-Cell Physiology. 287:C1077-C1086

Diabetes mellitus is a major risk factor in the development of atherosclerosis and cardiovascular disease conditions, involving intimal injury and enhanced vascular smooth muscle cell (VSMC) migration. We report a mechanistic basis for divergences be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde2eb4b86816b40707f02ab4051c400
https://doi.org/10.1152/ajpcell.00477.2003

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Analysis of Drosophila cGMP-dependent Protein Kinases and Assessment of Their in Vivo Roles by Targeted Expression in a Renal Transporting Epithelium

Autor: Matthew R. MacPherson, Suzanne M. Lohmann, Shireen A. Davies

Publikováno v: Journal of Biological Chemistry. 279:40026-40034

cGMP-dependent protein kinase (cGK) forms encoded by the dg2 (for) gene are implicated in behavior and epithelial transport in Drosophila melanogaster. Here, we provide the first biochemical characterization and cellular localization of cGKs encoded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3e2a1bd44bf92380ae97dc29df6bf5
https://doi.org/10.1074/jbc.m405619200

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Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes

Autor: Danny König, Gunnar Klein, Jörn Tongers, Beate Fiedler, Jörg Heineke, Kai C. Wollert, Helmut Drexler, Suzanne M. Lohmann, Stepan Gambaryan, Tibor Kempf, Theresia Kraft

Publikováno v: Cardiovascular Research. 63:545-552

Objective: Heme oxygenases (HO) are the rate-limiting enzymes in heme degradation, catalyzing the breakdown of heme to equimolar quantities of biliverdin (BV), carbon monoxide (CO), and ferrous iron. The inducible HO isoform, HO-1, confers protection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea4d8d3e81c94b93ed78aec0f911ce1
https://doi.org/10.1016/j.cardiores.2004.04.015

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Increased effects of C-type natriuretic peptide on contractility and calcium regulation in murine hearts overexpressing cyclic GMP-dependent protein kinase I

Autor: Kai C. Wollert, Suzanne M. Lohmann, Frank Begrow, Ulrich Walter, Sevdalina Yurukova, Stepan Gambaryan, Ana Kilic, Michaela Kuhn, Beate Fiedler

Publikováno v: British Journal of Pharmacology. 140:1227-1236

C-type natriuretic peptide (CNP) and its receptor guanylyl cyclase (GC-B) are expressed in the heart and modulate cardiac contractility in a cGMP-dependent manner. Since the distal cellular signalling pathways remain unclear, we evaluated the peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f9c0a5a89ca30351275e84ebe469f80
https://doi.org/10.1038/sj.bjp.0705567

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Physiology and Pathophysiology of Vascular Signaling Controlled by Cyclic Guanosine 3′,5′-Cyclic Monophosphate–Dependent Protein Kinase

Autor: Robert Feil, Ulrich Walter, Franz Hofmann, Thomas Münzel, Suzanne M. Lohmann, Alexander Mülsch

Publikováno v: Circulation. 108:2172-2183

Despite impressive medical advances1 that have led to diminished cardiovascular death rates in some countries over the past 20 years, cardiovascular disease remains the leading cause of death in developed countries such as the United States. This pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ab88a023ff00e1fe84f1a02ea6f4b03
https://doi.org/10.1161/01.cir.0000094403.78467.c3

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Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice

Autor: Hugo R. de Jonge, Ulrich Walter, Robert Feil, Franz Hofmann, Suzanne M. Lohmann

Publikováno v: Circulation Research, 93, 907-916. Lippincott Williams & Wilkins

Signaling cascades initiated by nitric oxide (NO) and natriuretic peptides (NPs) play an important role in the maintenance of cardiovascular homeostasis. It is currently accepted that many effects of these endogenous signaling molecules are mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d22534de7856b0c0940d3d614f58029
https://pure.eur.nl/en/publications/dab29d6d-b804-4904-9335-94d047181648

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