Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Suzanne M, Cutts"'
Autor:
Anna Konopka, Donna R. Whelan, Md Shafi Jamali, Emma Perri, Hamideh Shahheydari, Reka P. Toth, Sonam Parakh, Tina Robinson, Alison Cheong, Prachi Mehta, Marta Vidal, Audrey M. G. Ragagnin, Ivan Khizhnyak, Cyril J. Jagaraj, Jasmin Galper, Natalie Grima, Anand Deva, Sina Shadfar, Garth A. Nicholson, Shu Yang, Suzanne M. Cutts, Zuzana Horejsi, Toby D. M. Bell, Adam K. Walker, Ian P. Blair, Julie D. Atkin
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-28 (2020)
Abstract Background Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in TDP-43 are also present in ALS. Loss and gain of TDP-43 functions
Externí odkaz:
https://doaj.org/article/3003b649896947f29c746f302d459637
Autor:
Wil Gardner, David A. Winkler, Suzanne M. Cutts, Steven A. Torney, Geoffrey A. Pietersz, Benjamin W. Muir, Paul J. Pigram
Publikováno v:
Analytical Chemistry. 94:7804-7813
Feature extraction algorithms are an important class of unsupervised methods used to reduce data dimensionality. They have been applied extensively for time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging─commonly, matrix factorization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d564e54e9aba7092dd3ed364acef150
https://doi.org/10.1021/acs.analchem.1c05453
https://doi.org/10.1021/acs.analchem.1c05453
Autor:
Oula C. Mansour, Abraham Nudelman, Ada Rephaeli, Don R. Phillips, Suzanne M. Cutts, Benny J. Evison
Publikováno v:
Cancer Chemotherapy and Pharmacology. 89:773-784
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb5e36acd66c676857317f6b24b4a17
https://doi.org/10.1007/s00280-022-04435-1
https://doi.org/10.1007/s00280-022-04435-1
Publikováno v:
Laboratory Animals. 55:367-374
NSG™ mice are highly immunocompromised thus demonstrate high efficiency engraftment of patient-derived xenografts (PDXs) for pre-clinical oncology research. It has previously been reported that NSG™ mice are hyper-sensitive to doxorubicin due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bf7993c96b6c21bafbdaa62b1716cf
https://doi.org/10.1177/00236772211009338
https://doi.org/10.1177/00236772211009338
Autor:
Alison Cheong, Sonam Parakh, Sina Shadfar, Prachi Mehta, Shu Yang, Anand K. Deva, Anna Konopka, Natalie Grima, Adam K. Walker, Cyril J. Jagaraj, Emma R. Perri, Suzanne M. Cutts, Tina Robinson, Garth A. Nicholson, Hamideh Shahheydari, Reka P. Toth, Shafi Jamali, Julie D. Atkin, Audrey Ragagnin, Ian P. Blair, Toby D. M. Bell, Zuzana Horejsi, Marta Vidal, Ivan Khizhnyak, Donna R. Whelan, Jasmin Galper
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-28 (2020)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in TDP-43 are also present in ALS. Loss and gain of TDP-43 functions are impli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1571ac2e421081930780f50d6d1b402b
http://link.springer.com/article/10.1186/s13024-020-00386-4
http://link.springer.com/article/10.1186/s13024-020-00386-4
Autor:
Wil Gardner, Benjamin W. Muir, Ruqaya Maliki, Paul J. Pigram, Suzanne M. Cutts, David A. Winkler, Davide Ballabio
Publikováno v:
Analytical Chemistry. 92:10450-10459
We present an optimization of the toroidal self-organizing map (SOM) algorithm for the accurate visualization of hyperspectral data. This represents a significant advancement on our previous work, in which we demonstrated the use of toroidal SOMs for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eee080a506893175f1b564f3db6c6e2
https://doi.org/10.1021/acs.analchem.0c00986
https://doi.org/10.1021/acs.analchem.0c00986
Autor:
Oula C, Mansour, Abraham, Nudelman, Ada, Rephaeli, Don R, Phillips, Suzanne M, Cutts, Benny J, Evison
Publikováno v:
Cancer chemotherapy and pharmacology. 89(6)
Pixantrone is a synthetic aza-anthracenedione currently used in the treatment of non-Hodgkin's lymphoma. The drug is firmly established as a poison of the nuclear enzyme topoisomerase II, however, pixantrone can also generate covalent drug-DNA adduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::229458ca9d75d78a77adf2e3d6bb47df
https://pubmed.ncbi.nlm.nih.gov/35460360
https://pubmed.ncbi.nlm.nih.gov/35460360
Autor:
Wil Gardner, David A. Winkler, Ruqaya Maliki, Suzanne M. Cutts, Sarah Ellis, Robin L. Anderson, Benjamin W. Muir, Paul J. Pigram
Publikováno v:
Advanced Materials Interfaces. 9:2201464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19bd8c7f19154b09ef99bb8d8c66b9df
https://doi.org/10.1002/admi.202201464
https://doi.org/10.1002/admi.202201464
Publikováno v:
Analytical Chemistry. 91:13855-13865
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a powerful surface characterization technique capable of producing high spatial resolution hyperspectral images, in which each pixel comprises an entire mass spectrum. Such images can provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466d2d5e24beaefcb93df23f39fbaab4
https://doi.org/10.1021/acs.analchem.9b03322
https://doi.org/10.1021/acs.analchem.9b03322
Autor:
Keith G. Watson, Benny J. Evison, Brad E. Sleebs, Don R. Phillips, Jelena Medan, Suzanne M. Cutts, Kurt Lackovic
Publikováno v:
Bioorganicmedicinal chemistry letters. 35
Current techniques for the identification of DNA adduct-inducing and DNA interstrand crosslinking agents include electrophoretic crosslinking assays, electrophoretic gel shift assays, DNA and RNA stop assays, mass spectrometry-based methods and 32P-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ae5ce5bb8656e0213c964940bc8181
https://pubmed.ncbi.nlm.nih.gov/33486050
https://pubmed.ncbi.nlm.nih.gov/33486050