Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis.

Autor: Mikhail Lomonosov, El Kahina Meziane, Hongtao Ye, David E Nelson, Suzanne J Randle, Heike Laman

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e21165 (2011)

Fbxo7 is an unusual F box protein that augments D-type cyclin complex formation with Cdk6, but not Cdk4 or Cdk2, and its over-expression has been demonstrated to transform immortalised fibroblasts in a Cdk6-dependent manner. Here we present new evide

Externí odkaz: https://doaj.org/article/153ac863f59348c4b49bbdc5327612de

Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors

Autor: David B. Chou, Brooke A. Furlong, Ryan R. Posey, Christos Kyprianou, Lucy R. O’Sullivan, Rhiannon David, Suzanne J. Randle, Urszula M. Polanska, Jon Travers, Jelena Urosevic, John N. Hutchinson, Jianwei Che, Anna M. Howley, Robert P. Hasserjian, Rachelle Prantil-Baun, Donald E. Ingber

Publikováno v: Nature Communications. 13

Drug-induced cytopenias are a prevalent and significant issue that worsens clinical outcomes and hinders the effective treatment of cancer. While reductions in blood cell numbers are classically associated with traditional cytotoxic chemotherapies, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697ee99f28cb9514bae81925d3610705
https://doi.org/10.1038/s41467-022-33672-4

The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway

Autor: Patrícia Maria Siqueira dos Passos, Natália Borges Simaroli, Felipe R. Teixeira, Tycho E. T. Mevissen, Joice S. Oliveira, Marcelo D. Gomes, Heike Laman, Valentine Spagnol, Camila R.S.T.B. de Correia, Suzanne J. Randle, David Komander, Caio Almeida Batista de Oliveira, Ana C. Medeiros

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Biochimica et Biophysica Acta. General Subjects

Background Ubiquitously eXpressed Transcript isoform 2 (UXT—V2) is a prefoldin-like protein involved in NF-κB signaling, apoptosis, and the androgen and estrogen response. UXT-V2 is a cofactor in the NF-κB transcriptional enhanceosome, and its kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f95f5b0ac07eecea9d520eac11761e
https://www.repository.cam.ac.uk/handle/1810/310834

Analysis of the FBXO7 promoter reveals overlapping Pax5 and c-Myb binding sites functioning in B cells

Autor: Suzanne J. Randle, Heike Laman

Fbxo7 is a key player in the differentiation and function of numerous blood cell types, and in neurons, oligodendrocytes and spermatocytes. In an effort to gain insight into the physiological and pathological settings where Fbxo7 is likely to play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1a76e871823382c9697ddc8840a827

Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27

Autor: Suzanne J. Randle, Heike Laman, Anne Cooke, Shachi P. Patel, Sarah Gibbs

Publikováno v: Cellular and Molecular Life Sciences

G1 phase cell cycle proteins, such as cyclin-dependent kinase 6 (Cdk6) and its activating partners, the D-type cyclins, are important regulators of T-cell development and function. An F-box protein, called F-box only protein 7 (Fbxo7), acts as a cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bc6d8848fd25085672bd191a86e974
https://doi.org/10.1007/s00018-016-2427-3