Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Suzanne J, Hodgkinson"'
Autor:
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. Spicer, Nirupama D. Verma, Suzanne J. Hodgkinson, Bruce M. Hall
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The immune response to an allograft activates lymphocytes with the capacity to cause rejection. Activation of CD4+CD25+Foxp3+T regulatory cells (Treg) can down-regulate allograft rejection and can induce immune tolerance to the allograft. Treg repres
Externí odkaz:
https://doaj.org/article/9ec5c407df9a4a2ba527e4ce261d5650
Autor:
Nirupama D. Verma, Andrew D. Lam, Christopher Chiu, Giang T. Tran, Bruce M. Hall, Suzanne J. Hodgkinson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Resting and activated subpopulations of CD4+CD25+CD127loT regulatory cells (Treg) and CD4+CD25+CD127+ effector T cells in MS patients and in healthy individuals were compared. Peripheral blood mononuclear cells isolated using Ficoll Hypaque
Externí odkaz:
https://doaj.org/article/e08842a8d1044209a7ddc91f273c3f39
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The quest to understand how allogeneic transplanted tissue is not rejected and how tolerance is induced led to fundamental concepts in immunology. First, we review the research that led to the Clonal Deletion theory in the late 1950s that has since d
Externí odkaz:
https://doaj.org/article/63316bdc9d1e43d484326c936946be51
Autor:
Bruce M. Hall, Rachael M. Hall, Giang T. Tran, Catherine M. Robinson, Paul L. Wilcox, Prateek K. Rakesh, Chuanmin Wang, Alexandra F. Sharland, Nirupama D. Verma, Suzanne J. Hodgkinson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
CD4+CD25+Foxp3+T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cyto
Externí odkaz:
https://doaj.org/article/886ca1e1c5ef4eb18f1eef7445395015
Autor:
Nirupama D. Verma, Catherine M. Robinson, Nicole Carter, Paul Wilcox, Giang T. Tran, Chaunmin Wang, Alexandra Sharland, Masaru Nomura, Karren M. Plain, G. Alexander Bishop, Suzanne J. Hodgkinson, Bruce M. Hall
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells. Naïve tTreg from DA rats cultured wit
Externí odkaz:
https://doaj.org/article/80a584ad7fdd4a2d8602aba5e8068f8a
Autor:
Giang T. Tran, Paul L. Wilcox, Lindsay A. Dent, Catherine M. Robinson, Nicole Carter, Nirupama D. Verma, Bruce M. Hall, Suzanne J. Hodgkinson
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
ObjectiveTo examine if the protective effect of parasite infection on experimental autoimmune encephalomyelitis (EAE) was due to interleukin (IL)-5, a cytokine produced by a type-2 response that induces eosinophilia. We hypothesize that, in parasite
Externí odkaz:
https://doaj.org/article/7a495cbb719d4aff8d021e4f3366a103
Autor:
Bruce M. Hall, Catherine M. Robinson, Karren M. Plain, Nirupama D. Verma, Giang T. Tran, Masaru Nomura, Nicole Carter, Rochelle Boyd, Suzanne J. Hodgkinson
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Transplant tolerance induced in adult animals is mediated by alloantigen-specific CD4+CD25+ T cells, yet in many models, proliferation of CD4+ T cells from hosts tolerant to specific-alloantigen in vitro is not impaired. To identify changes that may
Externí odkaz:
https://doaj.org/article/161a845792b248a7b4dd11571defab37
Autor:
Jason, Cheung, Beata, Zahorowska, Michael, Suranyi, Jeffrey K W, Wong, Jason, Diep, Stephen T, Spicer, Nirupama D, Verma, Suzanne J, Hodgkinson, Bruce M, Hall
Publikováno v:
Frontiers in immunology. 13
The immune response to an allograft activates lymphocytes with the capacity to cause rejection. Activation of CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74dcef2a063d47915c7543f94b752659
https://pubmed.ncbi.nlm.nih.gov/36426347
https://pubmed.ncbi.nlm.nih.gov/36426347
Autor:
Nirupama Darshan Verma, Bruce Milne Hall, Karren Michelle Plain, Catherine M. Robinson, Rochelle eBoyd, Giang eTran, Chuanmin eWang, G. Alex eBishop, Suzanne J. Hodgkinson
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
In rat models, CD4+CD25+T regulatory cells (Treg) play a key role in the induction and maintenance of antigen specific transplant tolerance, especially in DA rats with PVG cardiac allografts(1, 2). We have previously described generation of alloantig
Externí odkaz:
https://doaj.org/article/b7dc6499fa174657bed254afd2d1e749
Autor:
Bruce Milne Hall, giang T Tran, Nirupama eVerma, Karren ePlain, Catherine M Robinson, Masaru eNomura, Suzanne J Hodgkinson
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Antigen specific Treg are often CD4+CD25+FoxP3+T cells, with a phenotype similar to natural Treg (nTreg). It is assumed that nTreg cannot develop into an antigen specific Treg as repeated culture with IL-2 and a specific antigen does not increase the
Externí odkaz:
https://doaj.org/article/cd9c4b0e106e4f02b3b254850319bd28