The Insulin-like Growth Factor-I–mTOR Signaling Pathway Induces the Mitochondrial Pyrimidine Nucleotide Carrier to Promote Cell Growth

Autor: Edmund R.S. Kunji, Dirk Jan Slotboom, Rosemary O'Connor, Giuseppe Trigiante, Suzanne Floyd, Ferdinando Palmieri, Cedric Favre, Gary Loughran, Madeline Leahy, Alexander Marx, Francesco M. Lasorsa, Katie O'Callaghan, Carlo M.T. Marobbio, Philipp Stroebel

Publikováno v: Molecular biology of the cell 18 (2007): 3545–3555. doi:10.1091/mbc.E06-12-1109
info:cnr-pdr/source/autori:Floyd S, Favre C, Lasorsa FM, Leahy M, Trigiante G, Stroebel P, Marx A, Loughran G, O'Callaghan K, Marobbio CM, Slotboom DJ, Kunji ER, Palmieri F, O'Connor R./titolo:The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth./doi:10.1091%2Fmbc.E06-12-1109/rivista:Molecular biology of the cell/anno:2007/pagina_da:3545/pagina_a:3555/intervallo_pagine:3545–3555/volume:18

The insulin/insulin-like growth factor (IGF) signaling pathway to mTOR is essential for the survival and growth of normal cells and also contributes to the genesis and progression of cancer. This signaling pathway is linked with regulation of mitocho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ea62a774407842fcc1f05c8c2b2fa6
https://doi.org/10.1091/mbc.e06-12-1109

Eukaryotic membrane protein overproduction in

Autor: Edmund R.S. Kunji, Dirk Jan Slotboom, Ka Wai Chan, Rosemary O'Connor, Suzanne Floyd, Magnus Monné

Publikováno v: Current Opinion in Biotechnology. 16:546-551

Eukaryotic membrane proteins play many vital roles in the cell and are important drug targets. Approximately 25% of all genes identified in the genome are known to encode membrane proteins, but the vast majority have no assigned function. Although th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3395ed8a434187fa4cc6178fb24a92fd
https://doi.org/10.1016/j.copbio.2005.08.006

A low-volume platform for cell-respirometric screening based on quenched-luminescence oxygen sensing

Autor: Rosemary O'Connor, James Hynes, Suzanne Floyd, Jan Krüger, John Alderman, Dmitri B. Papkovsky

Publikováno v: Biosensors and Bioelectronics. 19:1529-1535

Cell viability assays represent an important technology in modern cell biology, drug discovery and biotechnology, where currently there is a high demand for simple, sensitive and cost-effective screening methods. We have developed a new methodology a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9f54b23c0c3940a19a1dee01fd3370
https://doi.org/10.1016/j.bios.2003.12.008

Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1

Autor: Oliver T. Fackler, Chiara Marcozzi, Maria De Luca, Nicola Whiffin, Johnathan Watkins, Catherine Lindon, Mingwei Min, Suzanne Floyd, Stefan Kutscheidt, Kathryn Chung, Maria P. Gavilan

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Floyd, Suzanne et al.
Spatiotemporal regulation of mitotic kinase activity underlies the extensive rearrangement of cellular components required for cell division. One highly dynamic mitotic kinase is Aurora-B (AurB), which has multiple roles de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59f7eed45a59a1bbe67dfa3ecec0f45
http://hdl.handle.net/10261/122684