Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Suzanne F. Jones"'
Autor:
Melissa L Johnson, Manish R Patel, Raid Aljumaily, Suzanne F Jones, Howard A Burris, III, David R Spigel
Publikováno v:
The Oncologist.
Background This was an open-label, multicenter, single-arm phase Ib dose-escalation study of oral LCL161 administered in combination with oral topotecan in patients with relapsed/refractory small cell lung cancer (SCLC) and select gynecological cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::730af561bf4e796f75ca9047bd5f8cec
https://doi.org/10.1093/oncolo/oyad029
https://doi.org/10.1093/oncolo/oyad029
Autor:
Howard A. Burris, Jurgen Moll, Bernard Laffranchi, Silvia Comis, Roberta Ceruti, Maurizio Rocchetti, Mariangela Mariani, F. Anthony Greco, David R. Spigel, Jonathan Cheng, Margaret von Mehren, Charu Aggarwal, Suzanne F. Jones, Roger B. Cohen
Purpose: This study was conducted to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the i.v. pan-aurora kinase inhibitor PHA-739358, danusertib, in patients with advanced solid tumors.Experimental Design: In part 1, patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f464a8357ae84ce0b861e75ce7c7794
https://doi.org/10.1158/1078-0432.c.6517320
https://doi.org/10.1158/1078-0432.c.6517320
Autor:
Howard A. Burris, Stew Kroll, Hank Lee, Virginia K. Langmuir, Mario E. Lacouture, Suzanne F. Jones, Karen Lewandowski, Ramesh K. Ramanathan, Raoul Tibes, Julian R. Molina, Johanna C. Bendell, Mitesh J. Borad, E. Gabriela Chiorean, Jeffrey R. Infante, Glen J. Weiss
Purpose: The objectives of this phase 1, first-in-human study were to determine the dose-limiting toxicities (DLT), maximum tolerated dose (MTD), safety, pharmacokinetics, and preliminary activity of the hypoxia-activated prodrug TH-302 in patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbc6a5db7a51be43e7c571e20161d9d
https://doi.org/10.1158/1078-0432.c.6519608
https://doi.org/10.1158/1078-0432.c.6519608
Autor:
Howard A. Burris, Stew Kroll, Hank Lee, Virginia K. Langmuir, Mario E. Lacouture, Suzanne F. Jones, Karen Lewandowski, Ramesh K. Ramanathan, Raoul Tibes, Julian R. Molina, Johanna C. Bendell, Mitesh J. Borad, E. Gabriela Chiorean, Jeffrey R. Infante, Glen J. Weiss
Supplementary Figures S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ceda0ff5f30f766bc57e9960cb49ec5
https://doi.org/10.1158/1078-0432.22442993
https://doi.org/10.1158/1078-0432.22442993
Autor:
Karen A. Cadoo, David R. Spigel, Suzanne F. Jones, Juliann Chmielecki, Zhongwu Lai, Ganesh M. Mugundu, Sanjeev Kumar, Esteban Rodrigo Imedio, Janiel M. Cragun, Tiffany A. Troso-Sandoval, Jill J.J. Geenen, Daniel L. Spitz, Steven C. Plaxe, Gottfried E. Konecny, Sharad A. Ghamande, Amit M. Oza, Lee-may Chen, Erika P. Hamilton, Setsuko K. Chambers, Kathleen N. Moore
Supplementary tables S1-S3 and Supplementary figures S1-Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55af112ceb8321e8d2dd7167f8a42155
https://doi.org/10.1158/1078-0432.22484450.v1
https://doi.org/10.1158/1078-0432.22484450.v1
Autor:
Sunil Sharma, Matthew L. Sherman, Kenneth M. Attie, Ty McClure, Yijun Yang, Amelia E. Pearsall, Dawn Wilson, Carolyn H. Condon, Neeraj Agarwal, Gerard C. Blobe, David S. Mendelson, Suzanne F. Jones, Herbert I. Hurwitz, Michael S. Gordon, Johanna C. Bendell
PDF file - 7635K, Mean (plus-minus standard error) serum concentration of dalantercept versus time after first dose for each dose level.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6d6200a1a761ab7af3099097e0a6f7
https://doi.org/10.1158/1078-0432.22449399.v1
https://doi.org/10.1158/1078-0432.22449399.v1
Autor:
Karen A. Cadoo, David R. Spigel, Suzanne F. Jones, Juliann Chmielecki, Zhongwu Lai, Ganesh M. Mugundu, Sanjeev Kumar, Esteban Rodrigo Imedio, Janiel M. Cragun, Tiffany A. Troso-Sandoval, Jill J.J. Geenen, Daniel L. Spitz, Steven C. Plaxe, Gottfried E. Konecny, Sharad A. Ghamande, Amit M. Oza, Lee-may Chen, Erika P. Hamilton, Setsuko K. Chambers, Kathleen N. Moore
Purpose:This study assessed the efficacy, safety, and pharmacokinetics of adavosertib in combination with four chemotherapy agents commonly used in patients with primary platinum-resistant ovarian cancer.Patients and Methods:Women with histologically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329c4cb04a3b96cf79664f7505b8f71f
https://doi.org/10.1158/1078-0432.c.6530816
https://doi.org/10.1158/1078-0432.c.6530816
Autor:
Sunil Sharma, Matthew L. Sherman, Kenneth M. Attie, Ty McClure, Yijun Yang, Amelia E. Pearsall, Dawn Wilson, Carolyn H. Condon, Neeraj Agarwal, Gerard C. Blobe, David S. Mendelson, Suzanne F. Jones, Herbert I. Hurwitz, Michael S. Gordon, Johanna C. Bendell
Purpose: The angiogenesis inhibitor dalantercept (formerly ACE-041) is a soluble form of activin receptor–like kinase-1 (ALK1) that prevents activation of endogenous ALK1 by bone morphogenetic protein-9 (BMP9) and BMP10 and exhibits antitumor activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694c17cd967138109973f4aa65b00ace
https://doi.org/10.1158/1078-0432.c.6521646.v1
https://doi.org/10.1158/1078-0432.c.6521646.v1
Autor:
Howard A. Burris, Jurgen Moll, Bernard Laffranchi, Silvia Comis, Roberta Ceruti, Maurizio Rocchetti, Mariangela Mariani, F. Anthony Greco, David R. Spigel, Jonathan Cheng, Margaret von Mehren, Charu Aggarwal, Suzanne F. Jones, Roger B. Cohen
Supplementary Data from A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e396a140f5dd4ac23e5e39cd5e57d6
https://doi.org/10.1158/1078-0432.22439934
https://doi.org/10.1158/1078-0432.22439934
Autor:
Sunil Sharma, Matthew L. Sherman, Kenneth M. Attie, Ty McClure, Yijun Yang, Amelia E. Pearsall, Dawn Wilson, Carolyn H. Condon, Neeraj Agarwal, Gerard C. Blobe, David S. Mendelson, Suzanne F. Jones, Herbert I. Hurwitz, Michael S. Gordon, Johanna C. Bendell
PDF file - 43K, Tumor blood flow response to dalantercept as assessed by DCE-MRI. Best response measured as maximum percent change from baseline in median Ktrans at day 15.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59fcff9fc33fd65f00d8305b4563e2a0
https://doi.org/10.1158/1078-0432.22449396
https://doi.org/10.1158/1078-0432.22449396