Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Suzanne Elaine Keeling"'
Autor:
Lisa E. Ranshaw, Tracy Jane Shipley, Suzanne Elaine Keeling, Colin David Eldred, Nicola Mary Aston, B. Judkins, Ed Robinson, Kam Gohil, Naimisha Trivedi, Christopher James Lunniss, Andy Craven
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:137-140
Species specific conversion of the lead PDE4 inhibitor 1 to the quinolone 3 was identified as the major route of metabolism in the cynomolgus monkey. Modification of the template to give the cinnoline 9 retained potency and selectivity, and greatly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb271e1e882da928f3b0ee05c4c9fb31
https://doi.org/10.1016/j.bmcl.2009.11.010
https://doi.org/10.1016/j.bmcl.2009.11.010
Autor:
Fiona S. Lucas, Anthony William James Cooper, Ed Robinson, Ian Robert Baldwin, Charlotte J. Hardy, Giovanni Vitulli, Suzanne Elaine Keeling, Daniel Thomas, Joelle Le, Christopher James Lunniss, Sarah Smith, Zoe Alicia Harrison, Angela M. Deakin, Augustin Amour, Stefano Livia, Stephen Barry Guntrip, Yoshiaki Washio, Leigh M. Felton, Katherine Louise Jones, Nigel J. Parr, Kenneth David Down, Paul Jones, J. Nicole Hamblin, Paul Rowland
Publikováno v:
Journal of medicinal chemistry. 58(18)
Optimization of lead compound 1, through extensive use of structure-based design and a focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties, led to the discovery of clinical candidates 2 (GSK2269557) and 3 (GSK2292767) for the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f87d4bbb39df1904e25ad08de8b274b
https://pubmed.ncbi.nlm.nih.gov/26301626
https://pubmed.ncbi.nlm.nih.gov/26301626