Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Suzanne Egyhazi Brage"'
Autor:
Linda Vidarsdottir, Alireza Azimi, Ishani Das, Ingibjorg Sigvaldadottir, Aldwin Suryo Rahmanto, Andreas Petri, Sakari Kauppinen, Christian Ingvar, Göran Jönsson, Håkan Olsson, Marianne Frostvik Stolt, Rainer Tuominen, Olle Sangfelt, Katja Pokrovskaja Tamm, Johan Hansson, Dan Grandér, Suzanne Egyházi Brage, Per Johnsson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract BRAF inhibitors (BRAFi) selectively target oncogenic BRAFV600E/K and are effective in 80% of advanced cutaneous malignant melanoma cases carrying the V600 mutation. However, the development of drug resistance limits their clinical efficacy.
Externí odkaz:
https://doaj.org/article/f88ae22862f24b9684552bdca23e8edf
Autor:
Alireza Azimi, Stefano Caramuta, Brinton Seashore‐Ludlow, Johan Boström, Jonathan L Robinson, Fredrik Edfors, Rainer Tuominen, Kristel Kemper, Oscar Krijgsman, Daniel S Peeper, Jens Nielsen, Johan Hansson, Suzanne Egyhazi Brage, Mikael Altun, Mathias Uhlen, Gianluca Maddalo
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 3, Pp 1-16 (2018)
Abstract Novel therapies are undergoing clinical trials, for example, the Hsp90 inhibitor, XL888, in combination with BRAF inhibitors for the treatment of therapy‐resistant melanomas. Unfortunately, our data show that this combination elicits a het
Externí odkaz:
https://doaj.org/article/6c5b851e266f45048761038c0f72ccff
Autor:
Johan Falkenius, Hemming Johansson, Rainer Tuominen, Marianne Frostvik Stolt, Johan Hansson, Suzanne Egyhazi Brage
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-9 (2017)
Abstract Background The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might ben
Externí odkaz:
https://doaj.org/article/5fa8545fb29f49a5a271587254cb505a
Autor:
Anna-Maria Georgoudaki, Kajsa E. Prokopec, Vanessa F. Boura, Eva Hellqvist, Silke Sohn, Jeanette Östling, Rony Dahan, Robert A. Harris, Mattias Rantalainen, Daniel Klevebring, Malin Sund, Suzanne Egyhazi Brage, Jonas Fuxe, Charlotte Rolny, Fubin Li, Jeffrey V. Ravetch, Mikael C.I. Karlsson
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 2000-2011 (2016)
Tumors are composed of multiple cell types besides the tumor cells themselves, including innate immune cells such as macrophages. Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells present in the tumor microenvironmen
Externí odkaz:
https://doaj.org/article/cc3f009b26304544ac716a2b2776c512
Autor:
Fernanda Costa Svedman, Warangkana Lohcharoenkal, Matteo Bottai, Suzanne Egyhazi Brage, Enikö Sonkoly, Johan Hansson, Andor Pivarcsi, Hanna Eriksson
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206942 (2018)
BACKGROUND:Mitogen activated-protein kinase pathway inhibitors (MAPKis) improve treatment outcome in patients with disseminated BRAFV600 mutant cutaneous malignant melanoma (CMM) but responses are of limited duration due to emerging resistance. Altho
Externí odkaz:
https://doaj.org/article/c260dd7c8fc24f79b60ab83a1633c66f
Autor:
Ingrid Hedenfalk, Thomas Hatschek, Mårten Fernö, Thomas M. Walz, Martin Söderberg, Per-Olof Malmström, Niklas Loman, Barbro Linderholm, Elisabet Lidbrink, Zakaria Einbeigi, Lena Carlsson, Lambert Skoog, Marianne Frostvik Stolt, Suzanne Egyhazi Brage, Srinivas Veerla, Anna Danielsson, Ida Johansson, Siker Kimbung
Gene ontology analysis showing significantly enriched GO-terms for biological process among the significantly altered genes in breast cancer liver metastases compared to metastases from other sites.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b38291e98dcb4c049cac8d51d74590
https://doi.org/10.1158/1078-0432.22460037
https://doi.org/10.1158/1078-0432.22460037
Autor:
Ingrid Hedenfalk, Thomas Hatschek, Mårten Fernö, Thomas M. Walz, Martin Söderberg, Per-Olof Malmström, Niklas Loman, Barbro Linderholm, Elisabet Lidbrink, Zakaria Einbeigi, Lena Carlsson, Lambert Skoog, Marianne Frostvik Stolt, Suzanne Egyhazi Brage, Srinivas Veerla, Anna Danielsson, Ida Johansson, Siker Kimbung
Unsupervised HCL of an external dataset of breast cancer metastases (GSE14018) using the 358 "breast cancer liver metastasis-selective genes" derived from SAM analyses of metastases in the test dataset.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1fa17f99938b222b87207b9d6168b9
https://doi.org/10.1158/1078-0432.22460055
https://doi.org/10.1158/1078-0432.22460055
Autor:
Ingrid Hedenfalk, Thomas Hatschek, Mårten Fernö, Thomas M. Walz, Martin Söderberg, Per-Olof Malmström, Niklas Loman, Barbro Linderholm, Elisabet Lidbrink, Zakaria Einbeigi, Lena Carlsson, Lambert Skoog, Marianne Frostvik Stolt, Suzanne Egyhazi Brage, Srinivas Veerla, Anna Danielsson, Ida Johansson, Siker Kimbung
Purpose: The complete molecular basis of the organ-specificity of metastasis is elusive. This study aimed to provide an independent characterization of the transcriptional landscape of breast cancer metastases with the specific objective to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cea53a481eab204813314df3fe5f86
https://doi.org/10.1158/1078-0432.c.6524385
https://doi.org/10.1158/1078-0432.c.6524385
Autor:
Ingrid Hedenfalk, Thomas Hatschek, Mårten Fernö, Thomas M. Walz, Martin Söderberg, Per-Olof Malmström, Niklas Loman, Barbro Linderholm, Elisabet Lidbrink, Zakaria Einbeigi, Lena Carlsson, Lambert Skoog, Marianne Frostvik Stolt, Suzanne Egyhazi Brage, Srinivas Veerla, Anna Danielsson, Ida Johansson, Siker Kimbung
Baseline clinical and tumor pathological characteristics. Data are shown for all patients with metastatic breast cancer included in the TEX clinical trial and the subset of patients included in whole genome transcriptional analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b9b3d39a28dca193f54afc6023a2b5
https://doi.org/10.1158/1078-0432.22460043
https://doi.org/10.1158/1078-0432.22460043
Autor:
Ingrid Hedenfalk, Thomas Hatschek, Mårten Fernö, Thomas M. Walz, Martin Söderberg, Per-Olof Malmström, Niklas Loman, Barbro Linderholm, Elisabet Lidbrink, Zakaria Einbeigi, Lena Carlsson, Lambert Skoog, Marianne Frostvik Stolt, Suzanne Egyhazi Brage, Srinivas Veerla, Anna Danielsson, Ida Johansson, Siker Kimbung
Genes differential expressed between liver metastases compared to other metastatic sites. Two class SAM analyses was performed within the subset of ER positive tumors using the site (liver versus other) of metastasis as supervising variable. Genes we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2262e1206b526f9a5a2e3a8a042c2da6
https://doi.org/10.1158/1078-0432.22460040.v1
https://doi.org/10.1158/1078-0432.22460040.v1