Výsledky vyhledávání - "Suzanne E. Wahrle"

Akademický článek

Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β

Autor: Masayuki Morikawa, John D. Fryer, Patrick M. Sullivan, Erin A. Christopher, Suzanne E. Wahrle, Ronald B. DeMattos, Mark A. O'Dell, Anne M. Fagan, Hilal A. Lashuel, Thomas Walz, Kiyofumi Asai, David M. Holtzman

Publikováno v: Neurobiology of Disease, Vol 19, Iss 1, Pp 66-76 (2005)

The apolipoprotein E (apoE) genotype is an important genetic risk factor for Alzheimer's disease (AD). In the central nervous system (CNS), most apoE is produced by astrocytes and is present in unique high-density lipoprotein (HDL)-like particles tha

Externí odkaz: https://doaj.org/article/214fb0a157034797bffabec2f2d2b9c9

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Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β

Autor: David M. Holtzman, Anne M. Fagan, Erin Christopher, Mark A. O'Dell, Thomas Walz, Patrick Sullivan, Suzanne E. Wahrle, Ronald B. DeMattos, Masayuki Morikawa, John D. Fryer, Hilal A. Lashuel, Kiyofumi Asai

Publikováno v: Neurobiology of Disease, Vol 19, Iss 1, Pp 66-76 (2005)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2003ac09f98a81f343014df4cf2a81a4
http://www.sciencedirect.com/science/article/pii/S0969996104002797

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ABCA1 Is Required for Normal Central Nervous System ApoE Levels and for Lipidation of Astrocyte-secreted apoE

Autor: Suzanne E. Wahrle, Tomasz Kowalewski, Maia Parsadanian, David M. Holtzman, Justin Legleiter, Xianlin Han, Hong Jiang, John D. Fryer

Publikováno v: Journal of Biological Chemistry. 279:40987-40993

ABCA1 is an ATP-binding cassette protein that transports cellular cholesterol and phospholipids onto high density lipoproteins (HDL) in plasma. Lack of ABCA1 in humans and mice causes abnormal lipidation and increased catabolism of HDL, resulting in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d67274b9202599483b3d85ff2c06e24
https://doi.org/10.1074/jbc.m407963200

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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

Autor: Suzanne E. Wahrle, Kelly R. Bales, Jungsu Kim, Aimin Li, Steven M. Paul, David M. Holtzman, Amanda Knoten, Cheryl L. Wellington, Hong Jiang, Veronica Hirsch-Reinshagen, Maia Parsadanian, Sanjay Jain

APOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD). ABCA1, a member of the ATP-binding cassette family of active transporters, lipidates apoE in the CNS. Abca1(-/-) mice have decreased lipid associated with apoE and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2f1ece6a5bf6f335aaab39b0cb617c
https://europepmc.org/articles/PMC2200302/

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Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice

Autor: Suzanne E. Wahrle, Celina V. Zerbinatti, Judy Cam, Hyungjin Kim, Steven M. Paul, Kelly R. Bales, David M. Holtzman, Guojun Bu

Publikováno v: The Journal of biological chemistry. 281(47)

The low density lipoprotein receptor-related protein (LRP) is highly expressed in the brain and has been shown to alter the metabolism of amyloid precursor protein and amyloid-beta peptide (Abeta) in vitro. Previously we developed mice that overexpre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847d0334407097ae6e609807b93418f3
https://pubmed.ncbi.nlm.nih.gov/17012232

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Extragenic suppressors of the nimX2(cdc2) mutation of Aspergillus nidulans affect nuclear division, septation and conidiation

Autor: Peyton L. Hays, Robert L. Carter, Angela M. Payne, Melanie D. Schrader, Dana L. Roe, Suzanne E. Wahrle, Jerry L. C. Mamaril, Allison T. McElvaine, Sarah Lea McGuire, Sean P. Grace, Brett W. Carter, Gene A. Lang, Chad D. Young

Publikováno v: Scopus-Elsevier

The Aspergillus nidulans NIMXCDC2 protein kinase has been shown to be required for both the G2/M and G1/S transitions, and recent evidence has implicated a role for NIMXCDC2 in septation and conidiation. While much is understood of its G2/M function,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a68c8e46e77aecefc90a1aac1af89b
https://europepmc.org/articles/PMC1461382/

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