Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Suzanne Doolen"'
Autor:
Carl Laflamme, Allan I. Levey, S. J. Sukoff Rizzo, Riham Ayoubi, Sean-Paul G. Williams, Haian Fu, Ranjita Betarbet, Elizabeth Zoeller, Suzanne Doolen
Publikováno v:
F1000Research, Vol 12 (2024)
Background A major goal of the Target Enablement to Accelerate Therapy Development for Alzheimer’s disease (TREAT-AD) program is to develop and identify high-quality tools to test target or mechanistic hypotheses. As part of this initiative, it is
Externí odkaz:
https://doaj.org/article/96d1e51f90f64bbbbbbbaf6c13b8cfc5
Autor:
Cynthia D. Jesudason, Emily R. Mason, Shaoyou Chu, Adrian L. Oblak, June Javens‐Wolfe, Mustapha Moussaif, Greg Durst, Philip Hipskind, Daniel E. Beck, Jiajun Dong, Ovini Amarasinghe, Zhong‐Yin Zhang, Adam K. Hamdani, Kratika Singhal, Andrew D. Mesecar, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Disha M. Soni, Murugesh Kandasamy, Andrea R. Masters, Sara K Quinney, Suzanne Doolen, Hasi Huhe, Stacey J. Sukoff Rizzo, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract INTRODUCTION The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate‐5‐phosphatase (INPP5D), which encodes Src homology 2 (SH2) domain–containing inositol polyphosphat
Externí odkaz:
https://doaj.org/article/4d6f6a10135b4cdbb5e5fc4dd51947a7
Autor:
Ryan B. Griggs, Diogo F. Santos, Don E. Laird, Suzanne Doolen, Renee R. Donahue, Caitlin R. Wessel, Weisi Fu, Ghanshyam P. Sinha, Pingyuan Wang, Jia Zhou, Sebastian Brings, Thomas Fleming, Peter P. Nawroth, Keiichiro Susuki, Bradley K. Taylor
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 76-86 (2019)
Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes. Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to PDN in patients and pain-like behavior in rodent models of type 1 and t
Externí odkaz:
https://doaj.org/article/2a91aed0dd5b454d922c700e5c7d24d4
Publikováno v:
Neurobiology of Pain, Vol 7, Iss , Pp - (2020)
Endogenous lipid mediators are proposed to contribute to headache and facial pain by activating trigeminal neurons (TN). We recently identified 11-hydroxy-epoxide- and 11-keto-epoxide derivatives of linoleic acid (LA) that are present in human skin a
Externí odkaz:
https://doaj.org/article/c00e0c75625b44efb2d6ecd8d4ba33d2
Autor:
Timothy I Richardson, Cynthia D Jesudason, Karen L Lobb, Gregory L Durst, Brent Clayton, Steven M Massey, Daniel E Beck, Zhong‐Yin Zhang, Jiajun Dong, Jianping Lin, Jinmin Miao, Karson S Putt, Andrew D Mesecar, Adam K Hamdani, Emma K Lendy, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Shaoyou Chu, Emily R Mason, Adrian L Oblak, Disha Soni, Sara K Quinney, Larissa L Silva, Murugesh Kandasamy, Andrea R Masters, Stacey J Sukoff Rizzo, Suzanne Doolen, Kun Huang, Jie Zhang, Bruce T Lamb, Alan D Palkowitz
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78be85314990ac6063212d386aa1803
https://doi.org/10.1002/alz.068781
https://doi.org/10.1002/alz.068781
Autor:
Pingyuan Wang, Suzanne Doolen, Bradley K. Taylor, Don E. Laird, Ryan B. Griggs, Jia Zhou, Renee R. Donahue, Peter P. Nawroth, Ghanshyam P. Sinha, Weisi Fu, Sebastian Brings, Diogo F. Santos, Caitlin R. Wessel, Thomas Fleming, Keiichiro Susuki
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 127, Iss, Pp 76-86 (2019)
Neurobiol. Dis. 127, 76-86 (2019)
Neurobiology of Disease, Vol 127, Iss, Pp 76-86 (2019)
Neurobiol. Dis. 127, 76-86 (2019)
Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes. Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to PDN in patients and pain-like behavior in rodent models of type 1 and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c6a541c1e3c40a78e25c4eff3920a4
https://doi.org/10.1016/j.nbd.2019.02.019
https://doi.org/10.1016/j.nbd.2019.02.019
Autor:
Jose A. Morón, Carolyn M. Grachen, Renee R. Donahue, Ghanshyam P. Sinha, Bradley K. Taylor, Suzanne Doolen
Publikováno v:
Experimental Neurology. 314:58-66
Acute inflammation induces sensitization of nociceptive neurons and triggers the accumulation of calcium permeable (CP) α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) in the dorsal horn of the spinal cord. This coincides wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5182eec7b19b6f34497920a0633cb207
https://doi.org/10.1016/j.expneurol.2019.01.003
https://doi.org/10.1016/j.expneurol.2019.01.003
Autor:
Diogo F. Santos, Tyler S. Nelson, Na Ye, Weisi Fu, Javier J. Polania Gutierrez, Bradley K. Taylor, Suzanne Doolen, Jia Zhou
Publikováno v:
Pain
Peripheral inflammation produces a long-lasting latent sensitization of spinal nociceptive neurons, that is, masked by tonic inhibitory controls. We explored mechanisms of latent sensitization with an established four-step approach: (1) induction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8ff7af612b139458d9195a451b77e5
https://doi.org/10.1097/j.pain.0000000000001557
https://doi.org/10.1097/j.pain.0000000000001557
Autor:
Ulrich Sure, Katrin Anne Becker, Kristen McQuerry, Erhard Bieberich, Stefka D. Spassieva, Laura Goins, Erich Gulbins, Anne-Kathrin Uerschels, Jacek Bielawski, Bradley K. Taylor, Suzanne Doolen
Publikováno v:
J Neurochem
A major dose-limiting side effect of docetaxel chemotherapy is peripheral neuropathy. Patients’ symptoms include pain, numbness, tingling and burning sensations, and motor weakness in the extremities. The molecular mechanism is currently not unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875914420943aa2cc32f81de735587fa
https://www.ncbi.nlm.nih.gov/pubmed/32058598
https://www.ncbi.nlm.nih.gov/pubmed/32058598
Autor:
Shinichi Kohsaka, Christopher N. Honda, Bradley K. Taylor, Kelley F. Kitto, Lucy Vulchanova, Jennifer Cook, Maureen S. Riedl, Suzanne Doolen, Carolyn A. Fairbanks
Publikováno v:
Glia. 65:1976-1989
The complement 3a receptor (C3aR1) participates in microglial signaling under pathological conditions and was recently shown to be activated by the neuropeptide TLQP-21. We previously demonstrated that TLQP-21 elicits hyperalgesia and contributes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c72fa339f06aea1208f1eaa2552bd34
https://doi.org/10.1002/glia.23208
https://doi.org/10.1002/glia.23208