Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Suzanne Benjannet"'
Autor:
André J. Tremblay, Benoît Lamarche, Valéry Lemelin, Lizbeth Hoos, Suzanne Benjannet, Nabil G. Seidah, Jr. Harry R. Davis, Patrick Couture
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 3, Pp 558-565 (2011)
Inhibition of cholesterol synthesis by 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoAR) inhibitors has been associated with an increase in intestinal cholesterol absorption. This study examined how HMG-CoAR inhibition by atorvastatin modulates exp
Externí odkaz:
https://doaj.org/article/e0fff4ce37b64fb288719a8b97956b60
Autor:
Geneviève Dubuc, Michel Tremblay, Guillaume Paré, Hélène Jacques, Josée Hamelin, Suzanne Benjannet, Lucie Boulet, Jacques Genest, Lise Bernier, Nabil G. Seidah, Jean Davignon
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 1, Pp 140-149 (2010)
The proprotein convertase subtilisin kexin-9 (PCSK9) circulates in plasma as mature and furin-cleaved forms. A polyclonal antibody against human PCSK9 was used to develop an ELISA that measures total plasma PCSK9 rather than only the mature form. A c
Externí odkaz:
https://doaj.org/article/769387a049a44185b14c0a3457ca4a5a
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60095 (2013)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted inhibitor of the low-density lipoprotein (LDL) receptor and an important regulator of LDL metabolism. Elevated PCSK9 levels have been associated with cardiovascular risk. The purpose
Externí odkaz:
https://doaj.org/article/08aa8bed04584c339044572b353b279c
Autor:
Nabil G. Seidah, Annik Prat, Robert Day, Dorota Szumska, Rachid Essalmani, Shoumo Bhattacharya, Marie-Claude Asselin, Suzanne Benjannet, Ann Chamberland, Josée Hamelin, Daniel B. Constam, Delia Susan-Resiga
Bone morphogenetic protein 10 (BMP10) is a member of the TGF-β superfamily and plays a critical role in heart development. In the postnatal heart, BMP10 is restricted to the right atrium. The inactive pro-BMP10 (∼60 kDa) is processed into active B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c8264ee25ec01b3667d68fb07e18ff
https://doi.org/10.1074/jbc.m111.233577
https://doi.org/10.1074/jbc.m111.233577
Autor:
Subramanya N.M. Pandruvada, Jean Vacher, Monica Pata, Suzanne Benjannet, Nabil G. Seidah, Claude Lazure, Janie Beauregard
In humans and in mice, mutations in the Ostm1 gene cause the most severe form of osteopetrosis, a major bone disease, and neuronal degeneration, both of which are associated with early death. To gain insight into Ostm1 function, we first investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e0161d491b40fb9612b1b6d6c021b7
https://europepmc.org/articles/PMC4719428/
https://europepmc.org/articles/PMC4719428/
Publikováno v:
Journal of Biological Chemistry. 287:33745-33755
The proprotein convertase PCSK9 is a major target in the treatment of hypercholesterolemia because of its ability bind the LDL receptor (LDLR) and enhance its degradation in endosomes/lysosomes. In the endoplasmic reticulum, the zymogen pro-PCSK9 is
Autor:
Wilfried Le Goff, Josée Hamelin, Jean-Pierre Rabès, Zélie Julia, Dominique Bonnefont-Rousselot, Valérie Carreau, Olivier Meilhac, Mathilde Varret, Marianne Abifadel, Philippe Couvert, Nabil G. Seidah, Laurent Tosolini, Alain Carrié, John Chapman, Suzanne Benjannet, Eric Bruckert, Maryse Guerin, Jean-Baptiste Michel, Catherine Boileau, Annik Prat
Publikováno v:
Atherosclerosis. 223:394-400
Background The identification of mutations in PCSK9 (proprotein convertase subtilisin kexin9) in autosomal dominant hypercholesterolemia (ADH), has revealed the existence of a new player in cholesterol homeostasis. PCSK9 has been shown to enhance the
Autor:
Suzanne Benjannet, Jacques Genest, Nabil G. Seidah, Paul M. Ridker, Jean G. MacFadyen, Zuhier Awan, Daniel I. Chasman
Publikováno v:
Clinical Chemistry. 58:183-189
BACKGROUND Although statin therapy is known to increase concentrations of PCSK9, whether this effect is related to the magnitude of LDL reduction is uncertain. This study was undertaken to understand the extent of this effect and examine the relation
Autor:
Patrick Couture, Lizbeth Hoos, Valéry Lemelin, Benoît Lamarche, Jr. Harry R. Davis, Nabil G. Seidah, André J. Tremblay, Suzanne Benjannet
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 3, Pp 558-565 (2011)
Inhibition of cholesterol synthesis by 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoAR) inhibitors has been associated with an increase in intestinal cholesterol absorption. This study examined how HMG-CoAR inhibition by atorvastatin modulates exp
Publikováno v:
Journal of Biological Chemistry. 286:2728-2738
The zymogen activation mechanism and physiological functions of the most ancient and highly conserved basic amino acid-specific proprotein convertase 7 (PC7) are not known. Herein, we characterized the biosynthesis, subcellular localization, and traf