Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Suzanne A Hartford"'
Autor:
Suzanne A Hartford, Rajanikant Chittela, Xia Ding, Aradhana Vyas, Betty Martin, Sandra Burkett, Diana C Haines, Eileen Southon, Lino Tessarollo, Shyam K Sharan
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006236 (2016)
Human breast cancer susceptibility gene, BRCA2, encodes a 3418-amino acid protein that is essential for maintaining genomic integrity. Among the proteins that physically interact with BRCA2, Partner and Localizer of BRCA2 (PALB2), which binds to the
Externí odkaz:
https://doaj.org/article/63eebf230da248b88159d2f68914c5d8
Autor:
Yunhai Luo, Suzanne A Hartford, Ruizhu Zeng, Teresa L Southard, Naoko Shima, John C Schimenti
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004471 (2014)
Genome maintenance in germ cells is critical for fertility and the stable propagation of species. While mechanisms of meiotic DNA repair and chromosome behavior are well-characterized, the same is not true for primordial germ cells (PGCs), which aris
Externí odkaz:
https://doaj.org/article/9f08f75606b542ceae80a4632429fbd8
Autor:
Arun Prakash Mishra, Suzanne A. Hartford, Sounak Sahu, Kimberly Klarmann, Rajani Kant Chittela, Kajal Biswas, Albert B. Jeon, Betty K. Martin, Sandra Burkett, Eileen Southon, Susan Reid, Mary E. Albaugh, Baktiar Karim, Lino Tessarollo, Jonathan R. Keller, Shyam K. Sharan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mishra et al. have generated mice with a single amino acid substitution in BRCA2, which disrupts its interaction with DSS1 resulting in a severe HR defect. They show the interaction to be dispensable for HR at replication induced and meiotic DSBs.
Externí odkaz:
https://doaj.org/article/13f8d0d242734c8aae14e9ee7e9dbb0c
Autor:
Charleen Hunt, Suzanne A. Hartford, Derek White, Evangelos Pefanis, Timothy Hanna, Clarissa Herman, Jarrell Wiley, Heather Brown, Qi Su, Yurong Xin, Dennis Voronin, Hien Nguyen, Judith Altarejos, Keith Crosby, Jeffery Haines, Sarah Cancelarich, Meghan Drummond, Sven Moller-Tank, Ryan Malpass, Jacqueline Buckley, Maria del Pilar Molina-Portela, Gustavo Droguett, David Frendewey, Eric Chiao, Brian Zambrowicz, Guochun Gong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-Cas9 is a gene editing tool that can be used to modulate gene expression. Here, the authors report the generation of a mouse model that express all components of the CRISPR-Cas9 guide directed Synergistic Activation Mediator (SAM), demonstrate
Externí odkaz:
https://doaj.org/article/17fb14b41cbb4fa7890fbff2faf8ff19
Autor:
May E, Montasser, Cristopher V, Van Hout, Lawrence, Miloscio, Alicia D, Howard, Avraham, Rosenberg, Myrasol, Callaway, Biao, Shen, Ning, Li, Adam E, Locke, Niek, Verweij, Tanima, De, Manuel A, Ferreira, Luca A, Lotta, Aris, Baras, Thomas J, Daly, Suzanne A, Hartford, Wei, Lin, Yuan, Mao, Bin, Ye, Derek, White, Guochun, Gong, James A, Perry, Kathleen A, Ryan, Qing, Fang, Gannie, Tzoneva, Evangelos, Pefanis, Charleen, Hunt, Yajun, Tang, Lynn, Lee, Carole, Sztalryd-Woodle, Braxton D, Mitchell, Matthew, Healy, Elizabeth A, Streeten, Simeon I, Taylor, Jeffrey R, O'Connell, Aris N, Economides, Giusy, Della Gatta, Alan R, Shuldiner
Publikováno v:
Science (New York, N.Y.). 374(6572)
Increased blood levels of low-density lipoprotein cholesterol (LDL-C) and fibrinogen are independent risk factors for cardiovascular disease. We identified associations between an Amish-enriched missense variant (p.Asn352Ser) in a functional domain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b73b02316e34823aaf3cad8f3182e065
https://pubmed.ncbi.nlm.nih.gov/34855475
https://pubmed.ncbi.nlm.nih.gov/34855475
Autor:
Arun Prakash Mishra, Suzanne A. Hartford, Sounak Sahu, Kimberly Klarmann, Rajani Kant Chittela, Kajal Biswas, Albert B. Jeon, Betty K. Martin, Sandra Burkett, Eileen Southon, Susan Reid, Mary E. Albaugh, Baktiar Karim, Lino Tessarollo, Jonathan R. Keller, Shyam K. Sharan
Publikováno v:
Nature communications. 13(1)
The interaction between tumor suppressor BRCA2 and DSS1 is essential for RAD51 recruitment and repair of DNA double stand breaks (DSBs) by homologous recombination (HR). We have generated mice with a leucine to proline substitution at position 2431 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e70b63bffda9ce94432e0cdb3da695
https://pubmed.ncbi.nlm.nih.gov/35365640
https://pubmed.ncbi.nlm.nih.gov/35365640
Autor:
Jeremy O, Ward, Laura G, Reinholdt, Suzanne A, Hartford, Lawriston A, Wilson, Robert J, Munroe, Kerry J, Schimenti, Brian J, Libby, Marilyn, O'Brien, Janice K, Pendola, John, Eppig, John C, Schimenti
Publikováno v:
Biology of reproduction. 69(5)
The genetic control of mammalian gametogenesis is inadequately characterized because of a lack of mutations causing infertility. To further the discovery of genes required for mammalian gametogenesis, phenotype-driven screens were performed in mice u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdc937abfb327c62a6d790878779b2e7
https://pubmed.ncbi.nlm.nih.gov/12855593
https://pubmed.ncbi.nlm.nih.gov/12855593