Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Suzanne, Skolnik"'
Autor:
Upendra Argikar, Markus Blatter, Dallas Bednarczyk, Zhuoliang Chen, Young Shin Cho, Michaël Doré, Jennifer L. Dumouchel, Samuel Ho, Klemens Hoegenauer, Toshio Kawanami, Simon Mathieu, Erik Meredith, Henrik Möbitz, Stephen K. Murphy, Saravanan Parthasarathy, Carole Pissot Soldermann, Jobette Santos, Serena Silver, Suzanne Skolnik, Aleksandar Stojanovic
Publikováno v:
Journal of medicinal chemistry. 65(18)
An imidazolone → triazolone replacement addressed the limited passive permeability of a series of protein arginine methyl transferase 5 (PRMT5) inhibitors. This increase in passive permeability was unexpected given the increase in the hydrogen bond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1191a9529fb31bd9232e1a139ca91e82
https://pubmed.ncbi.nlm.nih.gov/36069672
https://pubmed.ncbi.nlm.nih.gov/36069672
Autor:
Shankara Anand, Stephane Rodde, Suzanne Skolnik, Peter Gedeck, William A. Shirley, Mika Lindvall, Brian Kelley, Mai Nguyen, Yipin Lu, Weiping Jia
Publikováno v:
Journal of Chemical Information and Modeling. 59:4706-4719
The acid–base dissociation constant, pKa, is a key parameter to define the ionization state of a compound and directly affects its biopharmaceutical profile. In this study, we developed a novel app...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00fbc3c4bb91c7c5502f38bf7b11d2e5
https://doi.org/10.1021/acs.jcim.9b00498
https://doi.org/10.1021/acs.jcim.9b00498
Publikováno v:
Journal of Chemical Information and Modeling. 57:1847-1858
It is widely understood that QSAR models greatly improve if more data are used. However, irrespective of model quality, once chemical structures diverge too far from the initial data set, the predictive performance of a model degrades quickly. To inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c6af0dea4f0a83b5ad75a540e441a3
https://doi.org/10.1021/acs.jcim.7b00315
https://doi.org/10.1021/acs.jcim.7b00315
Autor:
Yipin, Lu, Shankara, Anand, William, Shirley, Peter, Gedeck, Brian P, Kelley, Suzanne, Skolnik, Stephane, Rodde, Mai, Nguyen, Mika, Lindvall, Weiping, Jia
Publikováno v:
Journal of chemical information and modeling. 59(11)
The acid-base dissociation constant, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb1117075830bb05d250ede12ecbf29a
https://pubmed.ncbi.nlm.nih.gov/31647238
https://pubmed.ncbi.nlm.nih.gov/31647238
Publikováno v:
Journal of pharmaceutical sciences. 107(1)
Increasingly, in vitro assays evaluate a compound's tendency to maintain supersaturation toward improving oral absorption. Throughput remains a challenge and only small sets of compounds are evaluated in reported studies. The present work describes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7bc5e1d3674b52753b3a7110c26a3b
https://pubmed.ncbi.nlm.nih.gov/28551426
https://pubmed.ncbi.nlm.nih.gov/28551426
Autor:
Xuena Lin, Kelli Kuhen, Tao Wu, Elizabeth A. Winzeler, Christoph Fischli, Chun Li, Kerstin Gagaring, Jared Ek, Tiffany Chuan, Suresh B. Lakshminarayana, Rachel Borboa, Thomas Hollenbeck, Arnab K. Chatterjee, Fenghua Liu, Thierry T. Diagana, Richard Glynne, Caroline Francek, Reto Brun, Advait Nagle, John Isbell, Bo Liu, Christopher Caldwell, David C. Tully, David Plouffe, Tove Tuntland, Philip B. Alper, Suzanne Skolnik, Jonathan Chang, Jianling Wang, Matthias Rottmann, Zhong Chen
Publikováno v:
Journal of Medicinal Chemistry
On the basis of the initial success of optimization of a novel series of imidazolopiperazines, a second generation of compounds involving changes in the core piperazine ring was synthesized to improve antimalarial properties. These changes were carri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67dd0822748c0b26acd0f3ad90e7ef8
https://doi.org/10.1021/jm300041e
https://doi.org/10.1021/jm300041e
Autor:
Chen Christine Hiu-Tung, Remiszewski Stacy W, Jianmei Fan, Alex Fekete, Brant Firestone, Joseph D. Growney, Christopher T. Meta, Joe Eckman, Dyuti Majumdar, Ping Wang, Peter Atadja, Vinita Uttamsingh, Liping Zhou, Laszlo Urban, Qiang Lu, Meier Hsu, Suzanne Skolnik, Lei Jiang, Tim Ramsey, Martin Traebert, Yan Yan-Neale, Minying Pu, Julie Flynn, Lawrence Blas Perez, Yung-Mae Yao, Xueying Cao, Franco Lombardo, Steven Whitebread, Mats Holmqvist, Lewis Whitehead, Young Shin Cho, Paul Kwon, N Davis, Jack Green, Daniel Jansson, Michael Shultz, Gang Liu
Publikováno v:
Journal of Medicinal Chemistry. 54:4752-4772
Histone deacetylase (HDAC) inhibitors have shown promise in treating various forms of cancer. However, many HDAC inhibitors from diverse structural classes have been associated with QT prolongation in humans. Inhibition of the human ether a-go-go rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c444090ceb6d32a590072a95df83c006
https://doi.org/10.1021/jm200388e
https://doi.org/10.1021/jm200388e
Publikováno v:
Journal of Pharmaceutical Sciences. 99:3246-3265
We systematically validated a robust 96-well Caco-2 assay via an extended set of 93 marketed drugs with diverse transport mechanisms and quantified by LC/MS/MS, to investigate its predictive utility while dealing with challenging discovery compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342e32b267ccefb5622d7a82482724b7
https://doi.org/10.1002/jps.22080
https://doi.org/10.1002/jps.22080
Autor:
Weiping Jia, Stephane Rodde, Riccardo Vianello, Gavin Dollinger, Peter Gedeck, Franco Lombardo, Suzanne Skolnik, Bernard Faller, Yipin Lu, Giuliano Berellini
Publikováno v:
Journal of chemical information and modeling. 55(7)
The ionization state of drugs influences many pharmaceutical properties such as their solubility, permeability, and biological activity. It is therefore important to understand the structure property relationship for the acid-base dissociation consta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a930663653f83e15e0297cb0f42d467
https://pubmed.ncbi.nlm.nih.gov/26052622
https://pubmed.ncbi.nlm.nih.gov/26052622
Publikováno v:
Predictive ADMET: Integrative Approaches in Drug Discovery and Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2affe8d7597d0c960f30a11ad2a3febb
https://doi.org/10.1002/9781118783344.ch4
https://doi.org/10.1002/9781118783344.ch4
