Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Suzanne, Defelice"'
Publikováno v:
Marine Technology Society Journal. 45:88-100
The spatial and temporal variability of water quality within aquatic habitats in the Kaloko-Honokohau National Historical Park was examined over a 2-year period to quantitatively establish water quality benchmarks against which future data might be c
Autor:
Itay Perlstein, Erin Simmers, Amnon Hoffman, Suzanne DeFelice, Denise Y. Burton, Barry Campbell, Robert J. Levy, Kenneth Ryan, Jeanne M. Connolly
Publikováno v:
Human Gene Therapy. 16:906-910
The present study investigates a novel gene therapy approach for atrial arrhythmias, using a clarithromycin-responsive ion channel subunit mutation, hMiRP1-Q9E, cloned into an expression plasmid; wild-type expression plasmids encoding human minK-rela
Autor:
Jeanne M. Connolly, Elizabeth Palmatory, Navneet Narula, Jie Xu, Ivan S. Alferiev, Suzanne DeFelice, Naomi Eidelman, Robert J. Levy, Allyson Kronsteiner, Rachit Ohri, Narendra R. Vyavahare, Michael S. Sacks, Jocelyn N. Clark-Gruel
Publikováno v:
The American Journal of Pathology. 166:1-13
We investigated a novel polyepoxide crosslinker that was hypothesized to confer both material stabilization and calcification resistance when used to prepare bioprosthetic heart valves. Triglycidylamine (TGA) was synthesized via reacting epichlorhydr
Endovascular Microcoil Gene Delivery Using Immobilized Anti-adenovirus Antibody for Vector Tethering
Autor:
Robert J. Levy, John M. Abrahams, Scott L. Diamond, Cunxian Song, Suzanne DeFelice, M. Sean Grady
Publikováno v:
Stroke. 33:1376-1382
Background and Purpose — Endovascular microcoils are widely used in interventional procedures to treat cerebral aneurysms. In the present study we report for the first time successful use of an endovascular microcoil as a gene delivery system. Meth
Autor:
Xiumin Cui, Bruce D. Klugherz, Suzanne DeFelice, Zhiban Lu, Robert J. Levy, Robert L. Wilensky, J. Travis Hinson, Jeanne M. Connolly, Cunxian Song
Publikováno v:
Human Gene Therapy. 13:443-454
Deployment of coronary stents to relieve atherosclerotic obstruction has benefitted millions of patients. However, gene therapy to prevent in-stent restenosis, while promising in experimental studies, remains a challenge. Conventional strategies for
Autor:
K Ryan, Narendra R. Vyavahare, Robert J. Levy, J. Travis Hinson, Cunxian Song, Sruthi Tallapragada, Jeanne M. Connolly, Quanyi Li, Suzanne DeFelice
Publikováno v:
Gene Therapy. 8:659-667
Gene therapy with viral vectors has progressed to clinical trials. However, the localization of viral vector delivery to diseased target sites remains a challenge. We tested the hypothesis that an adenoviral vector could be successfully delivered by
Autor:
Marjan, Ghazvini-Boroujerdi, Jocelyn, Clark, Navneet, Narula, Elizabeth, Palmatory, Jeanne M, Connolly, Suzanne, DeFelice, Jie, Xu, Bo, Jian, Senator, Hazelwood, Robert J, Levy
Publikováno v:
The Journal of heart valve disease. 13(6)
Previous immunohistochemistry studies have shown that the transcription factor, Egr-1, is increased in human atherosclerotic lesions but is absent from the normal adjacent aortic wall. The hypothesis was investigated that Egr-1 is also increased in c
Autor:
Ivan S. Alferiev, Cunxian Song, Jeanne M. Connolly, Stanley J. Stachelek, Suzanne DeFelice, Richard W. Bianco, Robert J. Levy, Xiumin Cui
Publikováno v:
Gene therapy. 11(1)
The present study investigated a novel approach for gene therapy of heart valve disease and vascular disorders. We formulated and characterized implantable polyurethane films that could also function as gene delivery systems through the surface attac
Autor:
Denise Y. Burton, Robert J. Levy, Itay Perlstein, Suzanne DeFelice, Senator Hazelwood, Ilia Fishbein, Douglas A. Coulter, Cunxian Song, Quanyi Li, Jeanne M. Connolly
Publikováno v:
Human gene therapy. 14(9)
The present studies investigated the cardiac potassium channel missense mutation, Q9E-hMiRP1, for potential use as a gene therapy construct for cardiac arrhythmias. This gene abnormality is one of a number of mutations that can cause the long QT synd
Autor:
Xiumin Cui, Jeanne M. Connolly, Suzanne DeFelice, Bruce D. Klugherz, Weiliam Chen, Peter L. Jones, Robert J. Levy, Robert L. Wilensky, Nicolas F. Meneveau
Publikováno v:
Nature biotechnology. 18(11)
Expandable intra-arterial stents are widely used for treating coronary disease. We hypothesized that local gene delivery could be achieved with the controlled release of DNA from a polymer coating on an expandable stent. Our paper reports the first s