Available upon all requests? How and why we should better incentivize the sharing of biomaterials.

Autor: Suzannah J Rihn, Alexander Harms

Publikováno v: PLoS Biology, Vol 21, Iss 10, p e3002360 (2023)

Biomaterial sharing offers enormous benefits for research and for the scientific community. Individuals, funders, institutions, and journals can overcome the barriers to sharing and work together to promote a better sharing culture.

Externí odkaz: https://doaj.org/article/e70b73f7f83a47c094ba818360473e92

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction.

Autor: Hataf Khan, Helena Winstone, Jose M Jimenez-Guardeño, Carl Graham, Katie J Doores, Caroline Goujon, David A Matthews, Andrew D Davidson, Suzannah J Rihn, Massimo Palmarini, Stuart J D Neil, Michael H Malim

Publikováno v: PLoS Pathogens, Vol 17, Iss 11, p e1009820 (2021)

Interferons play a critical role in regulating host immune responses to SARS-CoV-2, but the interferon (IFN)-stimulated gene (ISG) effectors that inhibit SARS-CoV-2 are not well characterized. The IFN-inducible short isoform of human nuclear receptor

Externí odkaz: https://doaj.org/article/cc928219677448eabb1717d19393c336

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.

Autor: Suzannah J Rihn, Andres Merits, Siddharth Bakshi, Matthew L Turnbull, Arthur Wickenhagen, Akira J T Alexander, Carla Baillie, Benjamin Brennan, Fiona Brown, Kirstyn Brunker, Steven R Bryden, Kerry A Burness, Stephen Carmichael, Sarah J Cole, Vanessa M Cowton, Paul Davies, Chris Davis, Giuditta De Lorenzo, Claire L Donald, Mark Dorward, James I Dunlop, Matthew Elliott, Mazigh Fares, Ana da Silva Filipe, Joseph R Freitas, Wilhelm Furnon, Rommel J Gestuveo, Anna Geyer, Daniel Giesel, Daniel M Goldfarb, Nicola Goodman, Rory Gunson, C James Hastie, Vanessa Herder, Joseph Hughes, Clare Johnson, Natasha Johnson, Alain Kohl, Karen Kerr, Hannah Leech, Laura Sandra Lello, Kathy Li, Gauthier Lieber, Xiang Liu, Rajendra Lingala, Colin Loney, Daniel Mair, Marion J McElwee, Steven McFarlane, Jenna Nichols, Kyriaki Nomikou, Anne Orr, Richard J Orton, Massimo Palmarini, Yasmin A Parr, Rute Maria Pinto, Samantha Raggett, Elaine Reid, David L Robertson, Jamie Royle, Natalia Cameron-Ruiz, James G Shepherd, Katherine Smollett, Douglas G Stewart, Meredith Stewart, Elena Sugrue, Agnieszka M Szemiel, Aislynn Taggart, Emma C Thomson, Lily Tong, Leah S Torrie, Rachel Toth, Margus Varjak, Sainan Wang, Stuart G Wilkinson, Paul G Wyatt, Eva Zusinaite, Dario R Alessi, Arvind H Patel, Ali Zaid, Sam J Wilson, Suresh Mahalingam

Publikováno v: PLoS Biology, Vol 19, Iss 2, p e3001091 (2021)

The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the underlying cause of Coronavirus Disease 2019 (COVID-19), has led to a worldwide pandemic causing substantial morbidity, mortality, and economic devastation. In

Externí odkaz: https://doaj.org/article/cc007f107e3a422ab1bfef32714d1945

Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity

Autor: Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett

Publikováno v: PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)

Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469a676bb0e1666248dc84b8e1cb1c58
http://europepmc.org/articles/PMC8423302

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

Autor: Natalia Cameron-Ruiz, Siddharth Bakshi, Mark Dorward, Agnieszka M. Szemiel, Wilhelm Furnon, Matthew Elliott, Kathy Li, Rory Gunson, Giuditta De Lorenzo, Kirstyn Brunker, James G Shepherd, Anne Orr, Laura Sandra Lello, Dario R. Alessi, Stuart G. Wilkinson, Aislynn Taggart, Fiona Brown, Leah S. Torrie, C. James Hastie, Paul G. Wyatt, Margus Varjak, Joseph Hughes, Jamie Royle, Rajendra Lingala, Jenna Nichols, Daniel Mair, Xiang Liu, David Robertson, Vanessa M. Cowton, Chris Davis, Colin Loney, Kyriaki Nomikou, Nicola Goodman, James I. Dunlop, Sarah Cole, Natasha Johnson, Sam J. Wilson, Steven McFarlane, Kerry A. Burness, Claire L. Donald, Clare Johnson, Alain Kohl, Mazigh Fares, Rommel J. Gestuveo, Elaine Reid, Douglas G. Stewart, Paul Davies, Marion McElwee, E. Thomson, Akira J T Alexander, Daniel M. Goldfarb, Ali Zaid, Carla Baillie, Hannah Leech, Arthur Wickenhagen, Arvind H. Patel, Sainan Wang, Samantha Raggett, Gauthier Lieber, Benjamin Brennan, Katherine Smollett, Rute Maria Pinto, Vanessa Herder, Rachel Toth, Lily Tong, Joseph R Freitas, Eva Zusinaite, Suresh Mahalingam, Suzannah J. Rihn, Ana da Silva Filipe, Massimo Palmarini, Anna Geyer, Daniel M. Giesel, Steven R. Bryden, Andreas Merits, Richard J. Orton, Stephen Carmichael, Meredith Stewart, Elena Sugrue, Matthew L. Turnbull, Yasmin A Parr, Karen Kerr

Publikováno v: PLoS Biology
PLoS Biology, Vol 19, Iss 2, p e3001091 (2021)

The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the underlying cause of Coronavirus Disease 2019 (COVID-19), has led to a worldwide pandemic causing substantial morbidity, mortality, and economic devastation. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c299bf38b69d78c808a36826826130ef
https://eprints.gla.ac.uk/232858/1/232858.pdf