Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Suzanna Noy"'
Autor:
Phillip M. Muza, Marta Pérez, Suzanna Noy, Miyu Kurosawa, Loukia Katsouri, Victor L. J. Tybulewicz, Elizabeth M.C. Fisher, Steven J. West
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract Traditional histological analysis is conducted on thin tissue sections, limiting the data capture from large tissue volumes to 2D profiles, and requiring stereological methods for 3D assessment. Recent advances in microscopical and tissue cl
Externí odkaz:
https://doaj.org/article/7ae576e69dd646e7b72e01c4b67feac0
Autor:
Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris van Dalen, Martijn Verdoes, Elizabeth M. C. Fisher, Frances K. Wiseman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer’s disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (CSTB) is encoded on chromosome 21. Thus, individuals who have Down syndrome
Externí odkaz:
https://doaj.org/article/fdd398815b864621914e2872780af98c
Autor:
Eva Lana-Elola, Heather Cater, Sheona Watson-Scales, Simon Greenaway, Jennifer Müller-Winkler, Dorota Gibbins, Mihaela Nemes, Amy Slender, Tertius Hough, Piia Keskivali-Bond, Cheryl L. Scudamore, Eleanor Herbert, Gareth T. Banks, Helene Mobbs, Tara Canonica, Justin Tosh, Suzanna Noy, Miriam Llorian, Patrick M. Nolan, Julian L. Griffin, Mark Good, Michelle Simon, Ann-Marie Mallon, Sara Wells, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes. However, these dosage-sensitive cau
Externí odkaz:
https://doaj.org/article/2e0de4e621364f88bbb0ae2f68e17fe9
Autor:
Yixing Wu, Heather T Whittaker, Suzanna Noy, Karen Cleverley, Veronique Brault, Yann Herault, Elizabeth M C Fisher, Frances K Wiseman
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0242236 (2021)
People with Down syndrome (DS), caused by trisomy of chromosome 21 have a greatly increased risk of developing Alzheimer's disease (AD). This is in part because of triplication of a chromosome 21 gene, APP. This gene encodes amyloid precursor protein
Externí odkaz:
https://doaj.org/article/ef70aabd7c9645f4a1ceae65bf660fef
Autor:
Pishan Chang, Daniel Bush, Stephanie Schorge, Mark Good, Tara Canonica, Nathanael Shing, Suzanna Noy, Frances K. Wiseman, Neil Burgess, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth M.C. Fisher
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Summary: Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down syndrome (DS). Here, we demonstrate non-overlapping behavioral differences associ
Externí odkaz:
https://doaj.org/article/0726a09e79f942f28afb7ca0608d677c
Autor:
Phillip M. Muza, Marta Perez-Gonzalez, Suzanna Noy, Miyu Kurosawa, Loukia Katsouri, Victor L. J. Tybulewicz, Elizabeth M.C. Fisher, Steven J. West
Traditional histological analysis is conducted on thin tissue sections, limiting the data capture from large tissue volumes to 2D profiles, and requiring stereological methods for 3D assessment. Recent advances in microscopical and tissue clearing me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7645a5f9dbbd1f36e20411e893a88ffb
https://doi.org/10.21203/rs.3.rs-1991149/v1
https://doi.org/10.21203/rs.3.rs-1991149/v1
Autor:
Paige Mumford, Suzanna Noy, Victor L Tybulewicz, Elizabeth Fisher, Soyon Hong, Frances K Wiseman
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d05be627190d90f342d746f603e020d
https://doi.org/10.1002/alz.049216
https://doi.org/10.1002/alz.049216
The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model
Autor:
Véronique Brault, Heather T. Whittaker, Yixing Wu, Elizabeth M. C. Fisher, Suzanna Noy, Yann Herault, Frances K. Wiseman, Karen Cleverley
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2021, 16, ⟨10.1371/journal.pone.0242236⟩
PLoS ONE, Vol 16, Iss 7, p e0242236 (2021)
PLoS ONE, Public Library of Science, 2021, 16, ⟨10.1371/journal.pone.0242236⟩
PLoS ONE, Vol 16, Iss 7, p e0242236 (2021)
People with Down syndrome (DS), caused by trisomy of chromosome 21 have a greatly increased risk of developing Alzheimer’s disease (AD). This is in part because of triplication of a chromosome 21 gene, APP. This gene encodes amyloid precursor prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4483d113ebe945273be5872d7c1c25da
https://hal.archives-ouvertes.fr/hal-03373441/document
https://hal.archives-ouvertes.fr/hal-03373441/document
Autor:
Karen Cleverley, Yixing Wu, Heather T. Whittaker, Elizabeth M. C. Fisher, Suzanna Noy, Yann Herault, Véronique Brault, Frances K. Wiseman
People with Down syndrome (DS), caused by trisomy of chromosome 21 have a greatly increased risk of developing Alzheimer’s disease (AD). This is in part because of triplication of a chromosome 21 gene,APP. This gene encodes amyloid precursor protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10debea78dba60103fed3ab84a54af49
https://doi.org/10.1101/2020.10.30.362004
https://doi.org/10.1101/2020.10.30.362004
Autor:
Elizabeth M. C. Fisher, Suzanna Noy, Nathanael Shing, Stephanie Schorge, Daniel Bush, Victor L. J. Tybulewicz, Neil Burgess, Tara Canonica, Frances K. Wiseman, Mark Andrew Good, Pishan Chang, Matthew C. Walker
Publikováno v:
1163.e4
Cell Reports
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Cell Reports
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Summary Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down syndrome (DS). Here, we demonstrate non-overlapping behavioral differences associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5e6699f0a3da2804dd4e465cb08d89
http://hdl.handle.net/10044/1/76727
http://hdl.handle.net/10044/1/76727