Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Suzanna Kwong"'
Autor:
Suzanna Kwong, Weijun Weng, Donna Yosmanovich, Maria Rotter, Mikhail N. Zakharov, Alexey Aprelev, Frank A. Ferrone, Robin W. Briehl
Publikováno v:
Journal of Molecular Biology. 369:1170-1174
Sickle cell disease arises from a genetic mutation of one amino acid in each of the two hemoglobin beta chains, leading to the polymerization of hemoglobin in the red cell upon deoxygenation, and is characterized by vascular crises and tissue damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f0183e327ca3b077ecd0f27d8f6148
https://doi.org/10.1016/j.jmb.2007.04.030
https://doi.org/10.1016/j.jmb.2007.04.030
Publikováno v:
Biophysical Journal. 89:2677-2684
Sickle hemoglobin polymerizes by two types of nucleation: homogeneous nucleation of aggregates in solution, and heterogeneous nucleation on preexisting polymers. It has been proposed that the same contact that is made in the interior of the polymer b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96335ab36247775a9219cd1f50d224c
https://doi.org/10.1529/biophysj.105.067785
https://doi.org/10.1529/biophysj.105.067785
Publikováno v:
Biophysical Journal. 79(2):1016-1022
The homogeneous and heterogeneous nucleation kinetics of sickle hemoglobin (HbS) have been studied for various degrees of solution crowding by substitution of cross-linked hemoglobin A, amounting to 50% of the total hemoglobin. By cross-linking hemog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39284cf02bf183c7bf749369ffb19cff
Publikováno v:
Artificial Cells, Blood Substitutes, and Biotechnology. 27:185-202
Polyethylene glycol conjugation to proteins and peptides (PEGylation) has been shown to promote increased retention time in the circulation as well as to blunt immune or allergic reactions. PEGylated bovine hemoglobin (PEG-Hb) is being explored in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76e3e2f256c39509976d69fecd5c9d6
https://doi.org/10.3109/10731199909117693
https://doi.org/10.3109/10731199909117693
Autor:
Robin W. Briehl, Suzanna Kwong
Publikováno v:
Biophysical Journal. 100(3)
Red cell rigidification and damage due to polymerization and gelation of deoxygenated sickle cell hemoglobin lie at the root of pathogenesis in sickle cell disease. Although the abnormal blood rheology and gel viscosity have been studied, viscoelasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea362b1ec1453f62b05a2c54bf76152
Autor:
Frank A. Ferrone, Alexey Aprelev, Antonio Emanuele, Suzanna Kwong, Yihua Wang, Robin W. Briehl
Publikováno v:
Biophysical Journal. 98(3)
We have developed a novel method for measuring light scattering to observe critical fluctuations in hemoglobin (Hb) solutions. A small rectangular cell (0.2 x 4.0 x 30 mm) is filled with 24 μL of Hb solution. An optical fiber with outer diameter of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd58e49fc0d66234855a7d3bfabc8c4
The stability of the heme-globin linkage in some normal, mutant, and chemically modified hemoglobins
Autor:
Suzanna Kwong, Ruth E. Benesch
Publikováno v:
Journal of Biological Chemistry. 265:14881-14885
The rates and equilibria of heme exchange between methemoglobin and serum albumin were measured using a simple new spectrophotometric method. It is based on the large difference between the spectrum of methemoglobin and that of methemealbumin at pH 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8a5ac3d0398ddc5f165b9919c2e096
https://doi.org/10.1016/s0021-9258(18)77197-4
https://doi.org/10.1016/s0021-9258(18)77197-4
Autor:
Hacene Boukari, Jiang Cheng Wang, Zakaria M'Rah, Thomas K. Aldrich, Suzanna Kwong, W. David Appel, Robin W. Briehl
Publikováno v:
Biophysical Journal. 104(2):559a-560a
Our kinetic studies have characterized the mechanisms of deoxyhemoglobin S polymer depolymerization when exposed to CO (used as a model for oxygen because rates can be controlled photolytically). Fibers dissolve slowly, losing monomers from their end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09904163a5f87f3fa542ef082bce4747
Autor:
Suzanna Kwong, Scott M. Cohen, Robin W. Briehl, Gunjan Agarwal, Frank A. Ferrone, Robert Josephs, Jiang Cheng Wang
Publikováno v:
Journal of molecular biology. 322(2)
We examined the depolymerization of hemoglobin (Hb) S fibers in the presence of CO by using photolysis of COHbS to create and isolate individual fibers, then removing photolysis to induce depolymerization. Depolymerization occurs at two sites, fiber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930de7865a34ccfd0b64c08639237e99
https://pubmed.ncbi.nlm.nih.gov/12217699
https://pubmed.ncbi.nlm.nih.gov/12217699
Autor:
Alexey Aprelev, Robin W. Briehl, Dana Dragos, Suzanna Kwong, Maria A. Rotter, Frank A. Ferrone
Publikováno v:
Clinical Pharmacology & Therapeutics. 75:248-249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0837985f01b8018a70b86a1f93a6b1f3
https://doi.org/10.1016/j.clpt.2003.10.009
https://doi.org/10.1016/j.clpt.2003.10.009