Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Suzanna, Paterson"'
Autor:
Stephanie Ascough, PhD, Pete Dayananda, MBChB, Mohini Kalyan, MSc, Seng Ung Kuong, MSc, Zoe Gardener, BSc, Emma Bergstrom, BSc, Suzanna Paterson, MbBChBAO, Satwik Kar, PhD, Vedika Avadhan, MRes, Ryan Thwaites, PhD, Ashley Sanchez Sevilla Uruchurtu, BSc, Tracy J Ruckwardt, PhD, Man Chen, MD, Deepika Nair, MS, Alexandrine Derrien-Colemyn, PhD, Barney S Graham, MD, Malcolm Begg, PhD, Edith Hessel, PhD, Peter Openshaw, ProfFMedSci, Christopher Chiu, ProfPhD
Publikováno v:
The Lancet. Healthy Longevity, Vol 3, Iss 6, Pp e405-e416 (2022)
Summary: Background: Respiratory viral infections are typically more severe in older adults. Older adults are more vulnerable to infection and do not respond effectively to vaccines due to a combination of immunosenescence, so-called inflamm-ageing,
Externí odkaz:
https://doaj.org/article/8d3c14033c20433d979206677c1a5568
Autor:
Benjamin H, Schott, Liuyang, Wang, Xinyu, Zhu, Alfred T, Harding, Emily R, Ko, Jeffrey S, Bourgeois, Erica J, Washington, Thomas W, Burke, Jack, Anderson, Emma, Bergstrom, Zoe, Gardener, Suzanna, Paterson, Richard G, Brennan, Christopher, Chiu, Micah T, McClain, Christopher W, Woods, Simon G, Gregory, Nicholas S, Heaton, Dennis C, Ko
Publikováno v:
Cell genomics. 2(11)
During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::375f0e4e6f2c25d65219308a87b43d6b
https://pubmed.ncbi.nlm.nih.gov/36465279
https://pubmed.ncbi.nlm.nih.gov/36465279
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Respiratory syncytial virus (RSV) and influenza are among the most important causes of severe respiratory disease worldwide. Despite the clinical need, barriers to developing reliably effective vaccines against these viruses have remained firmly in p
Externí odkaz:
https://doaj.org/article/137a3ad31ec74f708a722d529adcc066
Autor:
Benjamin H. Schott, Liuyang Wang, Xinyu Zhu, Alfred T. Harding, Emily R. Ko, Jeffrey S. Bourgeois, Erica J. Washington, Thomas W. Burke, Jack Anderson, Emma Bergstrom, Zoe Gardener, Suzanna Paterson, Richard G. Brennan, Christopher Chiu, Micah T. McClain, Christopher W. Woods, Simon G. Gregory, Nicholas S. Heaton, Dennis C. Ko
During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human in vitro susceptibility testing (scHi-HOST), a method for rapidly identifying genetic variants that confer resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ba3d18cfb5edf87a1e40e2fbe068b3
http://hdl.handle.net/10044/1/100790
http://hdl.handle.net/10044/1/100790
Autor:
Benjamin H. Schott, Liuyang Wang, Xinyu Zhu, Alfred T. Harding, Emily R. Ko, Jeffrey S. Bourgeois, Erica J. Washington, Thomas W. Burke, Jack Anderson, Emma Bergstrom, Zoe Gardener, Suzanna Paterson, Richard G. Brennan, Christopher Chiu, Micah T. McClain, Christopher W. Woods, Simon G. Gregory, Nicholas S. Heaton, Dennis C. Ko
SummaryDiversity in the human genome is one factor that confers resistance and susceptibility to infectious diseases. This is observed most dramatically during pandemics, where individuals exhibit large differences in risk and clinical outcomes again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67f3d505c6414d2fc1557705d16e6647
https://doi.org/10.1101/2022.01.30.478319
https://doi.org/10.1101/2022.01.30.478319
Autor:
John Sidney, Jie Zhu, Emma Bergstrom, Sebastian L. Johnston, Agnieszka Jozwik, Allan Paras, Jerico Del Rosario, Peter J. M. Openshaw, Christopher Chiu, Onn Min Kon, Mohini Kalyan, Aleks Guvenel, Ernie Wong, Satwik Kar, Suzanna Paterson, Patrick Mallia, Annemarie Sykes, Zoe Gardener, Maximillian S. Habibi, Alessandro Sette, Mark H. Almond, Mirae Park, Bjoern Peters, Jaideep Dhariwal, Stephanie Ascough, Seng Kuong Ung, Maria-Belen Trujillo-Torralbo
Publikováno v:
The Journal of Clinical Investigation
Guvenel, A, Jozwik, A, Ascough, S, Ung, S K, Paterson, S, Kalyan, M, Gardener, Z, Bergstrom, E, Kar, S, Habibi, M S, Paras, A, Zhu, J, Park, M, Dhariwal, J, Almond, M, Wong, E H C, Sykes, A, Del Rosario, J, Trujillo-torralbo, M, Mallia, P, Sidney, J, Peters, B, Kon, O M, Sette, A, Johnston, S L, Openshaw, P J & Chiu, C 2019, ' Epitope-specific airway-resident CD4 + T cell dynamics during experimental human RSV infection ', Journal of Clinical Investigation, vol. 130, no. 1, pp. 523-538 . https://doi.org/10.1172/JCI131696
Guvenel, A, Jozwik, A, Ascough, S, Ung, S K, Paterson, S, Kalyan, M, Gardener, Z, Bergstrom, E, Kar, S, Habibi, M S, Paras, A, Zhu, J, Park, M, Dhariwal, J, Almond, M, Wong, E H C, Sykes, A, Del Rosario, J, Trujillo-torralbo, M, Mallia, P, Sidney, J, Peters, B, Kon, O M, Sette, A, Johnston, S L, Openshaw, P J & Chiu, C 2019, ' Epitope-specific airway-resident CD4 + T cell dynamics during experimental human RSV infection ', Journal of Clinical Investigation, vol. 130, no. 1, pp. 523-538 . https://doi.org/10.1172/JCI131696
BACKGROUND. Respiratory syncytial virus (RSV) is an important cause of acute pulmonary disease and one of the last remaining major infections of childhood for which there is no vaccine. CD4+ T cells play a key role in antiviral immunity, but they hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad6fb3c7f29125e82058fb5fbe069af
https://doi.org/10.1172/jci131696
https://doi.org/10.1172/jci131696
Autor:
Christopher W. Woods, Zoe Gardener, Onn Min Kon, Agnieszka Jozwik, Peter J. M. Openshaw, Bradly P. Nicholson, Patrick Mallia, Satwik Kar, Suzanna Paterson, Jeroen Maertzdorf, Mohini Kalyan, Hans-Joachim Mollenkopf, Hannah Jarvis, January Weiner, Seng Kuong Ung, Akhilesh Jha, Stefan H. E. Kaufmann, Timothy Veldman, Joanna Zyla, Stephanie Ascough, Emma Bergstrom, Christopher Chiu
Publikováno v:
Am J Respir Crit Care Med
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
Rationale: Suboptimal vaccine immunogenicity and antigenic mismatch, compounded by poor uptake, means that influenza remains a major global disease. T cells recognizing peptides derived from conserved viral proteins could enhance vaccine-induced cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b7f8274beb78131939c09ac3102551
https://europepmc.org/articles/PMC8528532/
https://europepmc.org/articles/PMC8528532/