Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Suzana T. Cunha Lima"'
Autor:
Nadja Aparecida M. de Lima, Laila Gabriel Ecard, Edson Rodrigues, Luciana Veiga, Carlos Eduardo Sampaio Guedes, Solange Andrade, Suzana T. Cunha Lima
Publikováno v:
Industrial Biotechnology. 18:77-82
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::945d6dea4822a145ff53921fee208188
https://doi.org/10.1089/ind.2022.0008
https://doi.org/10.1089/ind.2022.0008
Publikováno v:
Journal of Endocrinology. 210:125-134
We previously reported that mutations in the thyroid hormone receptor (TR) surface that mediates dimer and heterodimer formation do not alter affinity for cognate hormone (triiodothyronine (T3)) yet dramatically enhance T3 association and dissociatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f163d9c9fc751818746c33370bb54af5
https://doi.org/10.1530/joe-11-0019
https://doi.org/10.1530/joe-11-0019
Autor:
Ben Sandler, John D. Baxter, Robert J. Fletterick, James W. Apriletti, Hoa Nguyen, Brian L. West, B. Russell Huber, Suzana T. Cunha Lima
Publikováno v:
Molecular Endocrinology. 17:643-652
Resistance to hormones is commonly due to mutations in genes encoding receptors. Resistance to thyroid hormone is due mostly to mutations of the beta-form of the human (h) thyroid hormone receptor (hTRbeta). We determined x-ray crystal structures of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f885b69bb9cb1385d541db352fa350c4
https://doi.org/10.1210/me.2002-0095
https://doi.org/10.1210/me.2002-0095
Autor:
James W. Apriletti, Ngoc Ha Nguyen, Paul Webb, Suzana T. Cunha Lima, Thomas S. Scanlan, John D. Baxter
Publikováno v:
Journal of Medicinal Chemistry. 45:3310-3320
Recent efforts have focused on the design and synthesis of thyroid hormone (T(3)) antagonists as potential therapeutic agents and chemical probes to understand hormone-signaling pathways. We previously reported the development of novel first-generati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee07e7cf813211f912970edd404996d0
https://doi.org/10.1021/jm0201013
https://doi.org/10.1021/jm0201013
Autor:
B. Russell Huber, Suzana T. Cunha Lima, Andrew K. Shiau, Alexander E. Kelly, Robert J. Fletterick, Richard L. Wagner, Brian L. West, James W. Apriletti, Thomas S. Scanlan, John D. Baxter
Publikováno v:
Molecular Endocrinology. 15:398-410
Separate genes encode thyroid hormone receptor subtypes TRalpha (NR1A1) and TRbeta (NR1A2). Products from each of these contribute to hormone action, but the subtypes differ in tissue distribution and physiological response. Compounds that discrimina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f71bb11f38a70a08812d0ae8bca0d0
https://doi.org/10.1210/mend.15.3.0608
https://doi.org/10.1210/mend.15.3.0608
Publikováno v:
Thyroid and Parathyroid Diseases-New Insights into Some Old and Some New Issues
Nuclear receptors (NRs) are transcription factors that regulate gene expression in response to small signaling molecules. The NR family includes receptors for thyroid hormone (TH) (Yen, 2001), retinoids, vitamin D, steroid hormones, fatty acids, bile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5312d779287a55b7fd53817d4ab55f0b
https://doi.org/10.5772/35134
https://doi.org/10.5772/35134
Autor:
Marie Togashi, James W. Apriletti, Robert J. Fletterick, John D. Baxter, Ben Sandler, Suzana T. Cunha Lima, Sanja Juric, Stefan Nilsson, Paul Webb, B. Russell Huber, Richard L. Wagner
Publikováno v:
Repositório Institucional da UnB
Universidade de Brasília (UnB)
instacron:UNB
Universidade de Brasília (UnB)
instacron:UNB
Thyroid hormone (TH) actions are mediated by nuclear receptors (TRs alpha and beta) that bind triiodothyronine (T(3), 3,5,3'-triiodo-l-thyronine) with high affinity, and its precursor thyroxine (T(4), 3,5,3',5'-tetraiodo-l-thyronine) with lower affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc54155a7aafb2699a928015b23462f0
http://repositorio.unb.br/handle/10482/13249
http://repositorio.unb.br/handle/10482/13249
Autor:
Paul Webb, Sabine Borngraeber, Marie Togashi, Suzana T. Cunha-Lima, Robert J. Fletterick, Thomas S. Scanlan, Mary Jane Budny, Grazia Chiellini, John D. Baxter
Selective therapeutics for nuclear receptors would revolutionize treatment for endocrine disease. Specific control of nuclear receptor activity is challenging because the internal cavities that bind hormones can be virtually identical. Only one highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ab4d66596b3c74818379a00c69c847
https://europepmc.org/articles/PMC307572/
https://europepmc.org/articles/PMC307572/
Autor:
Suzana T. Cunha Lima, Paul Webb, Ralff C. J. Ribeiro, Robert J. Fletterick, Thomas S. Scanlan, Grazia Chiellini, Ngoc Ha Nguyen, Brian L. West, James W. Apriletti, Adhirai Marimuthu, Karin Mellstrom, Hikari A. I. Yoshihara, Patrick Goede, John D. Baxter, Peter J. Kushner, Stefan Nilsson
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 83(1-5)
It is desirable to obtain TR antagonists for treatment of hyperthyroidism and other conditions. We have designed TR antagonists from first principles based on TR crystal structures. Since agonist ligands are buried in the fold of the TR ligand bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ec0d71506d47e0c2975dba76e50add
https://pubmed.ncbi.nlm.nih.gov/12650702
https://pubmed.ncbi.nlm.nih.gov/12650702
Autor:
Suzana T. Cunha-Lima, Robert J. Fletterick, Marion Desclozeaux, Holly A. Ingraham, Hoa Nguyen, John D. Baxter, Brian L. West, B. Russell Huber
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 17(1)
Resistance to thyroid hormone (RTH) syndrome is associated with mutations in the human thyroid hormone receptor-beta (hTRbeta), many of which show marked reduction in hormone binding. Here, we investigated the structural consequences of two RTH mutan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a94360f43633b523d48c34a6f0b6cae
https://pubmed.ncbi.nlm.nih.gov/12511610
https://pubmed.ncbi.nlm.nih.gov/12511610