Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Suzana Kovac"'
Autor:
Suzana Kovac, Preethne Böser, Yifang Cui, Dunja Ferring-Appel, Daniela Casarrubea, Lili Huang, Emma Fung, Andreas Popp, Bernhard K. Mueller, Matthias W. Hentze
Publikováno v:
Haematologica, Vol 101, Iss 5 (2016)
Externí odkaz:
https://doaj.org/article/21d9c65f352246baa8f40c09ab7c37c1
Autor:
Weranja K B Ranasinghe, Lin Xiao, Suzana Kovac, Mike Chang, Carine Michiels, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54251 (2013)
BackgroundCastrate-resistant prostate cancer (CRPC) is a lethal condition in patients receiving androgen deprivation therapy for prostate cancer (PC). Despite numerous studies showing the expression of HIF1α protein under normoxia in PC cell lines,
Externí odkaz:
https://doaj.org/article/8fdcdc1151e14acaa32d31f37447b1a2
Autor:
Emma Fung, Dunja Ferring-Appel, Matthias W. Hentze, Lili Huang, Andreas Popp, Bernhard K. Mueller, Yi-Fang Cui, Preethne Böser, Suzana Kovac, Daniela Casarrubea
Publikováno v:
Haematologica. 101(5)
Current therapies for anemia associated with high hepcidin have limited success. Humanized monoclonal antibodies targeting hemojuvelin decrease hepcidin and improve anemia in three preclinical models. The antihemojuvelin antibodies were successfully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff1168fd05e90e0e2795e37de9f9b04
https://pubmed.ncbi.nlm.nih.gov/26944476
https://pubmed.ncbi.nlm.nih.gov/26944476
Publikováno v:
Endocrinology. 153:3006-3016
Gastrin and its precursors have been shown to promote mitogenesis and angiogenesis in gastrointestinal tumors. Hypoxia stimulates tumor growth, but its effect on gastrin gene regulation has not been examined in detail. Here we have investigated the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbabeef3b341bf3d507c4ef3c044172
https://doi.org/10.1210/en.2011-2069
https://doi.org/10.1210/en.2011-2069
Publikováno v:
Biochemical Pharmacology. 83:524-530
The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated gastrins in vitro and in vivo. Bi3+ ions also bind to glycine-extended gastrin17 (Ggly), but inhibit Ggly-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7096cf48cf598ae3def5b2b4a68e9e
https://doi.org/10.1016/j.bcp.2011.11.030
https://doi.org/10.1016/j.bcp.2011.11.030
Publikováno v:
FEBS Letters. 584:4413-4418
The involvement of the gastrointestinal hormone gastrin in the development of gastrointestinal cancer is highly controversial. Here we demonstrate a positive-feedback loop whereby gastrin, acting via the CCK2 receptor, increases its own expression. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c177f84780df0e998c10b7699ace0f
https://doi.org/10.1016/j.febslet.2010.09.046
https://doi.org/10.1016/j.febslet.2010.09.046
Autor:
Shamilah Lachal, Gianni Bramante, Audrey Ferrand, Graham S. Baldwin, Arthur Shulkes, Suzana Kovac
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G220-G227
Precursors of the peptide hormone gastrin stimulate proliferation in the colorectal mucosa and promote the development of colorectal carcinoma. Gastrins bind two ferric ions selectively and with high affinity, and the biological activity of glycine-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9aafc832e4646d770901d648b9679b
https://doi.org/10.1152/ajpgi.00046.2010
https://doi.org/10.1152/ajpgi.00046.2010
Publikováno v:
FEBS Journal. 276:4866-4874
Transferrin is the main iron transport protein found in the circulation, and the level of transferrin saturation in the blood is an important indicator of iron status. The peptides amidated gastrin(17) (Gamide) and glycine-extended gastrin(17) (Ggly)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f18d507a8dd585725e672cab090902da
https://doi.org/10.1111/j.1742-4658.2009.07186.x
https://doi.org/10.1111/j.1742-4658.2009.07186.x
Autor:
Graham S. Baldwin, Gregory J. Anderson, Kelly A. Smith, Suzana Kovac, John Burgess, Arthur Shulkes
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 295:G855-G861
The observations that the peptide hormone gastrin interacts with transferrin in vitro and that circulating gastrin concentrations are increased in the iron-loading disorder hemochromatosis suggest a possible link between gastrin and iron homeostasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6d4338e41c07064c1e037f3e27331e
https://doi.org/10.1152/ajpgi.90359.2008
https://doi.org/10.1152/ajpgi.90359.2008
Publikováno v:
Applied and Environmental Microbiology. 71:8402-8410
Only one isolate each of the class “ Spartobacteria ” (subdivision 2 of the phylum Verrucomicrobia ) and of subdivision 3 of Verrucomicrobia have previously been reported to grow in laboratory culture. Using media that had been used successfully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e05220f564e1d84a0199b6926e956e
https://doi.org/10.1128/aem.71.12.8402-8410.2005
https://doi.org/10.1128/aem.71.12.8402-8410.2005