Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Suzana Hadjur"'
Autor:
Hayley Porter, Yang Li, Maria Victoria Neguembor, Manuel Beltran, Wazeer Varsally, Laura Martin, Manuel Tavares Cornejo, Dubravka Pezić, Amandeep Bhamra, Silvia Surinova, Richard G Jenner, Maria Pia Cosma, Suzana Hadjur
Publikováno v:
eLife, Vol 12 (2023)
Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion that the SA subunit is not a m
Externí odkaz:
https://doaj.org/article/c75b957f25434498af13a92ce3fcf355
Autor:
Emily Brookes, Braulio Martinez De La Cruz, Paraskevi Boulasiki, Ho Yu Alan Au, Wazeer Varsally, Christopher Barrington, Suzana Hadjur, Antonella Riccio
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105695- (2023)
Summary: Brain-derived neurotrophic factor (BDNF) promotes neuronal differentiation and survival and is implicated in the pathogenesis of many neurological disorders. Here, we identified a novel intergenic enhancer located 170 kb from the Bdnf gene,
Externí odkaz:
https://doaj.org/article/d50510c3558141e0825d0e225c4889b8
Autor:
Christopher Barrington, Dimitra Georgopoulou, Dubravka Pezic, Wazeer Varsally, Javier Herrero, Suzana Hadjur
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Eukaryotic genomes fold into topologically associated domains (TAD). Here the authors characterise a TAD regulatory architecture underlying lineage-specific gene regulation, finding that stripe TADs are associated with poised and active chromatin lan
Externí odkaz:
https://doaj.org/article/4079930968d542f19a66096e3016823b
Autor:
Matteo Vietri Rudan, Christopher Barrington, Stephen Henderson, Christina Ernst, Duncan T. Odom, Amos Tanay, Suzana Hadjur
Publikováno v:
Cell Reports, Vol 10, Iss 8, Pp 1297-1309 (2015)
Topological domains are key architectural building blocks of chromosomes, but their functional importance and evolutionary dynamics are not well defined. We performed comparative high-throughput chromosome conformation capture (Hi-C) in four mammals
Externí odkaz:
https://doaj.org/article/cc59aeeb53de47679cf94e6a2d71441c
Autor:
Emily Brookes, Braulio Martinez De La Cruz, Paraskevi Boulasiki, Ho Yu Alan Au, Wazeer Varsally, Christopher Barrington, Suzana Hadjur, Antonella Riccio
Brain-derived neurotrophic factor (BDNF) promotes neuronal differentiation and survival and is implicated in the pathogenesis of many neurological disorders. Here, we identified a novel intergenic enhancer located 170 kb from the Bdnf gene, which pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810cc02c25540cb814435a6bf3292df2
https://eprints.soton.ac.uk/474269/
https://eprints.soton.ac.uk/474269/
Autor:
Emily, Brookes, Braulio, Martinez De La Cruz, Paraskevi, Boulasiki, Ho Yu Alan, Au, Wazeer, Varsally, Christopher, Barrington, Suzana, Hadjur, Antonella, Riccio
Publikováno v:
iScience. 26(1)
Brain-derived neurotrophic factor (BDNF) promotes neuronal differentiation and survival and is implicated in the pathogenesis of many neurological disorders. Here, we identified a novel intergenic enhancer located 170 kb from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d1d3593f4d930bd9edb6f062f27ca11
https://pubmed.ncbi.nlm.nih.gov/36582820
https://pubmed.ncbi.nlm.nih.gov/36582820
Autor:
Laura Martin, Amandeep Bhamra, Maria Victoria Neguembor, Wazeer Varsally, Manuel Beltran, Suzana Hadjur, Silvia Surinova, Yun Li, Porter H, Cornejo Mt, Maria Pia Cosma, Richard G. Jenner, Dubravka Pezic
Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion that the SA subunit is not a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddf6cac010cd1c460fff0aa0aee132f4
https://doi.org/10.1101/2021.02.20.432055
https://doi.org/10.1101/2021.02.20.432055
Autor:
Steve M Pollard, Pooran Singh Dewari, Weeks S, Dubravka Pezic, Suzana Hadjur, Miguel R. Branco, Wazeer Varsally
Several studies have shown a role for Stag proteins in cell identity. Our understanding of how Stag proteins contribute to cell identity have largely been focused on its roles in chromosome topology as part of the cohesin complex and the impact on pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7713761673a4d1bb25a337654f006866
https://doi.org/10.1101/2021.02.14.429938
https://doi.org/10.1101/2021.02.14.429938
Autor:
Ye Zhan, Hongbo Yang, Lijun Zhang, William Stafford Noble, Dubravka Pezic, Victoria T. Le, Duncan T. Odom, Rajinder Kaul, David M. Gilbert, Christopher Pool, Ross C. Hardison, James R. Broach, Job Dekker, Suzana Hadjur, Vishnu Dileep, Darrin V. Bann, Jesse R. Dixon, Ferhat Ay, Tingting Liu, Yanli Wang, Jie Xu, Bryan R. Lajoie, Sriranga Iyyanki, Christina Ernst, John A. Stamatoyannopoulos, Michael Buckley, Abhijit Chakraborty, Juan Carlos Rivera-Mulia, Feng Yue, Takayo Sasaki, Kristen Lee, Royden A. Clark, Morgan Diegel, Lin An, Hakan Ozadam, Galip Gürkan Yardımcı, Fan Song
Publikováno v:
Nature Genetics. 50:1388-1398
Structural variants can contribute to oncogenesis through a variety of mechanisms. Despite their importance, the identification of structural variants in cancer genomes remains challenging. Here, we present a framework that integrates optical mapping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb10305ce347ee812c83011a65c0df3e
https://doi.org/10.1038/s41588-018-0195-8
https://doi.org/10.1038/s41588-018-0195-8
Publikováno v:
Chromosome Research
Extensive research has revealed that cohesin acts as a topological device, trapping chromosomal DNA within a large tripartite ring. In so doing, cohesin contributes to the formation of compact and organized genomes. How exactly the cohesin subunits i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359ecfddaa74fd0b2c19110d0bb8db9c
https://doi.org/10.1007/s10577-017-9550-3
https://doi.org/10.1007/s10577-017-9550-3