Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Suzana D. Savkovic"'
Autor:
Jenisha Ghimire, Rida Iftikhar, Harrison M. Penrose, Patricia Snarski, Emmanuelle Ruiz, Suzana D. Savkovic
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9730 (2023)
Inflammatory bowel disease (IBD), characterized by infiltration of polymorphonuclear neutrophils (PMNs), increases the risk of colon cancer. PMN activation corresponds to the accumulation of intracellular Lipid Droplets (LDs). As increased LDs are ne
Externí odkaz:
https://doaj.org/article/9025387fd6c4439aa9ed162655b02fa0
Autor:
Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Joshua S. Samudre, Morgan E. Collins, Alifiani B. Hartono, Sean B. Lee, Frank Lau, Melody Baddoo, Erik F. Flemington, Susan E. Crawford, Suzana D. Savkovic
Publikováno v:
Oncogenesis, Vol 10, Iss 11, Pp 1-10 (2021)
Abstract Obesity is a worldwide epidemic associated with increased risk and progression of colon cancer. Here, we aimed to determine the role of adipose triglyceride lipase (ATGL), responsible for intracellular lipid droplet (LD) utilization, in obes
Externí odkaz:
https://doaj.org/article/dad0fa3c4c914a0ebba7e45d5f2c7f93
Autor:
Harrison M. Penrose, Rida Iftikhar, Morgan E. Collins, Eman Toraih, Emmanuelle Ruiz, Nathan Ungerleider, Hani Nakhoul, Erik F. Flemington, Emad Kandil, Shamita B. Shah, Suzana D. Savkovic
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The heterogeneous pathobiology underlying Ulcerative Colitis (UC) is not fully understood. Using publicly available transcriptomes from adult UC patients, we identified the immune cell landscape, molecular pathways, and differentially expres
Externí odkaz:
https://doaj.org/article/e760a94f0fe148a6a82d2a1f02490469
Autor:
Rida Iftikhar, Patricia Snarski, Angelle N. King, Jenisha Ghimire, Emmanuelle Ruiz, Frank Lau, Suzana D. Savkovic
Publikováno v:
Cancers, Vol 15, Iss 3, p 977 (2023)
The obesity epidemic is associated with increased colorectal cancer (CRC) risk and progression, the mechanisms of which remain unclear. In obese individuals, hypertrophic epiploic adipose tissue (EPAT), attached to the colon, has unique characteristi
Externí odkaz:
https://doaj.org/article/74ef834fdbae4cdb804aadb9112657f8
Autor:
Botle Precious Damane, Thanyani Victor Mulaudzi, Sayed Shakeel Kader, Pragalathan Naidoo, Suzana D. Savkovic, Zodwa Dlamini, Zilungile Lynette Mkhize-Kwitshana
Publikováno v:
Cancers, Vol 15, Iss 3, p 748 (2023)
The advancement of HIV treatment has led to increased life expectancy. However, people living with HIV (PLWH) are at a higher risk of developing colorectal cancers. Chronic inflammation has a key role in oncogenesis, affecting the initiation, promoti
Externí odkaz:
https://doaj.org/article/03f227d62efc470f9dcbdae158de0525
Autor:
Emmanuelle Ruiz, Harrison M. Penrose, Sandra Heller, Hani Nakhoul, Melody Baddoo, Erik F. Flemington, Emad Kandil, Suzana D. Savkovic
Publikováno v:
Gut Microbes, Vol 11, Iss 3, Pp 350-363 (2020)
Inflammatory bowel disease (IBD) has been linked to active signaling with bacterial components and reduced mitochondrial ATP production; however, synergism between both of these disease characteristics remains unclear. We aimed to determine in human
Externí odkaz:
https://doaj.org/article/15355e26874241f1bf6b0de62ccbd1f3
Autor:
Suzana D. Savkovic
Publikováno v:
Gut Microbes, Vol 11, Iss 3, Pp 249-252 (2020)
Externí odkaz:
https://doaj.org/article/2f06dcef80bd489faf9ff41ac0056ab1
Autor:
Harrison M. Penrose, Chloe Cable, Sandra Heller, Nathan Ungerleider, Hani Nakhoul, Melody Baddoo, Alifiani B. Hartono, Sean B. Lee, Matthew E. Burow, Erik F. Flemington, Susan E. Crawford, Suzana D. Savkovic
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 391-408 (2019)
Background & Aims: Diminished forkhead box O3 (FOXO3) function drives inflammation and cancer growth; however, mechanisms fostering these pathobiologies are unclear. Here, we aimed to identify in colon loss of FOXO3-dependent cellular and molecular c
Externí odkaz:
https://doaj.org/article/7337e8aa807f4d11a94daa9ce23793f7
Autor:
Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Joshua S. Samudre, Morgan E. Collins, Alifiani B. Hartono, Sean B. Lee, Frank Lau, Melody Baddoo, Erik F. Flemington, Susan E. Crawford, Suzana D. Savkovic
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/df3e440f84514614aa5dd372b8cc26ab
Autor:
Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Yunah Kim, Emmanuelle Ruiz, Emad Kandil, Heather L. Machado, Suzana D. Savkovic
Publikováno v:
Metabolites, Vol 12, Iss 3, p 250 (2022)
Obesity, characterized by augmented inflammation and tumorigenesis, is linked to genetic predispositions, such as FOXO3 polymorphisms. As obesity is associated with aberrant macrophages infiltrating different tissues, including the colon, we aimed to
Externí odkaz:
https://doaj.org/article/8360caa076894cf0a3351031caf80f12