Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Suzan Stelloo"'
Autor:
Chia-Chi Flora Huang, Shreyas Lingadahalli, Tunc Morova, Dogancan Ozturan, Eugene Hu, Ivan Pak Lok Yu, Simon Linder, Marlous Hoogstraat, Suzan Stelloo, Funda Sar, Henk van der Poel, Umut Berkay Altintas, Mohammadali Saffarzadeh, Stephane Le Bihan, Brian McConeghy, Bengul Gokbayrak, Felix Y. Feng, Martin E. Gleave, Andries M. Bergman, Colin Collins, Faraz Hach, Wilbert Zwart, Eldon Emberly, Nathan A. Lack
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background Androgen receptor (AR) is critical to the initiation, growth, and progression of prostate cancer. Once activated, the AR binds to cis-regulatory enhancer elements on DNA that drive gene expression. Yet, there are 10–100× more b
Externí odkaz:
https://doaj.org/article/f44c462b807b4890bf2fd42d2752fc95
Autor:
Suzan Stelloo, Ekaterina Nevedomskaya, Yongsoo Kim, Karianne Schuurman, Eider Valle-Encinas, João Lobo, Oscar Krijgsman, Daniel Simon Peeper, Seiwon Laura Chang, Felix Yi-Chung Feng, Lodewyk Frederik Ary Wessels, Rui Henrique, Carmen Jerónimo, Andries Marinus Bergman, Wilbert Zwart
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The Androgen Receptor (AR) is the main driver of prostate cancer and functions in conjunction with chromatin modifications. Here, the authors comprehensively profile 100 primary prostate carcinomas by sequencing RNA transcripts in combination with Ch
Externí odkaz:
https://doaj.org/article/effc0af426e44531a865abc7a1346937
Autor:
Sander AL Palit, Daniel Vis, Suzan Stelloo, Cor Lieftink, Stefan Prekovic, Elise Bekers, Ingrid Hofland, Tonći Šuštić, Liesanne Wolters, Roderick Beijersbergen, Andries M Bergman, Balázs Győrffy, Lodewyk FA Wessels, Wilbert Zwart, Michiel S van der Heijden
Publikováno v:
eLife, Vol 8 (2019)
Androgen receptor (AR) inhibitors represent the mainstay of prostate cancer treatment. In a genome-wide CRISPR-Cas9 screen using LNCaP prostate cancer cells, loss of co-repressor TLE3 conferred resistance to AR antagonists apalutamide and enzalutamid
Externí odkaz:
https://doaj.org/article/caac5d360d0a4963af4d216fca34abf4
Autor:
Bianca Cioni, Ekaterina Nevedomskaya, Monique H. M. Melis, Johan vanBurgsteden, Suzan Stelloo, Emma Hodel, Daniele Spinozzi, Jeroen deJong, Henk vander Poel, Jan Paul deBoer, Lodewyk F. A. Wessels, Wilbert Zwart, Andries M. Bergman
Publikováno v:
Molecular Oncology, Vol 12, Iss 8, Pp 1308-1323 (2018)
Fibroblasts are abundantly present in the prostate tumor microenvironment (TME), including cancer‐associated fibroblasts (CAFs) which play a key role in cancer development. Androgen receptor (AR) signaling is the main driver of prostate cancer (PCa
Externí odkaz:
https://doaj.org/article/2fbada9ef3c642f4ad347138544195c4
Autor:
Suzan Stelloo, Ekaterina Nevedomskaya, Henk G van der Poel, Jeroen de Jong, Geert JLH van Leenders, Guido Jenster, Lodewyk FA Wessels, Andries M Bergman, Wilbert Zwart
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 11, Pp 1450-1464 (2015)
Abstract Prostate cancer is the second most prevalent malignancy in men. Biomarkers for outcome prediction are urgently needed, so that high‐risk patients could be monitored more closely postoperatively. To identify prognostic markers and to determ
Externí odkaz:
https://doaj.org/article/90f6ed52c3cb49288248300a76c053b7
Autor:
Ekaterina Nevedomskaya, Suzan Stelloo, Henk G. van der Poel, Jeroen de Jong, Lodewyk F.A. Wessels, Andries M. Bergman, Wilbert Zwart
Publikováno v:
Genomics Data, Vol 7, Iss , Pp 124-126 (2016)
Prostate cancer (PCa) is the second most common cancer in men. The Androgen Receptor (AR) is the major driver of PCa and the main target of therapy in the advanced setting. AR is a nuclear receptor that binds the chromatin and regulates transcription
Externí odkaz:
https://doaj.org/article/b998e6103c6047ab991fb8c113c9c991
Autor:
Wilbert Zwart, Andries M. Bergman, Henk van der Poel, Nathan A. Lack, Lisa M. Butler, Lodewyk F.A. Wessels, Matthew L. Freedman, Amina Zoubeidi, Felix Y. Feng, René H. Medema, Maarten Altelaar, Bogdan Pasaniuc, Ji-Heui Seo, Claudia Giambartolomei, Iris de Rink, Roelof J.C. Kluin, Jeroen de Jong, Dorine C. Hintzen, Anniek Zaalberg, Martin Sjöström, Sylvan C. Baca, Yongsoo Kim, Liesbeth Hoekman, Umut Berkay Altintas, Tunc Morova, Chia-Chi Flora Huang, Joyce Sanders, Tesa M. Severson, Elise M. Bekers, Maartje Alkemade, Hilda de Barros, Karianne Schuurman, Nils Eickhoff, Suzan Stelloo, Marlous Hoogstraat, Simon Linder
Supplementary Figure from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f42b86f8b15f67e1989e728942677f1
https://doi.org/10.1158/2159-8290.22541192
https://doi.org/10.1158/2159-8290.22541192
Autor:
Wilbert Zwart, Andries M. Bergman, Henk van der Poel, Nathan A. Lack, Lisa M. Butler, Lodewyk F.A. Wessels, Matthew L. Freedman, Amina Zoubeidi, Felix Y. Feng, René H. Medema, Maarten Altelaar, Bogdan Pasaniuc, Ji-Heui Seo, Claudia Giambartolomei, Iris de Rink, Roelof J.C. Kluin, Jeroen de Jong, Dorine C. Hintzen, Anniek Zaalberg, Martin Sjöström, Sylvan C. Baca, Yongsoo Kim, Liesbeth Hoekman, Umut Berkay Altintas, Tunc Morova, Chia-Chi Flora Huang, Joyce Sanders, Tesa M. Severson, Elise M. Bekers, Maartje Alkemade, Hilda de Barros, Karianne Schuurman, Nils Eickhoff, Suzan Stelloo, Marlous Hoogstraat, Simon Linder
In prostate cancer, androgen receptor (AR)–targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ac6a409e8171f21c2df0636766df70
https://doi.org/10.1158/2159-8290.c.6549566
https://doi.org/10.1158/2159-8290.c.6549566
Autor:
Wilbert Zwart, Andries M. Bergman, Henk van der Poel, Nathan A. Lack, Lisa M. Butler, Lodewyk F.A. Wessels, Matthew L. Freedman, Amina Zoubeidi, Felix Y. Feng, René H. Medema, Maarten Altelaar, Bogdan Pasaniuc, Ji-Heui Seo, Claudia Giambartolomei, Iris de Rink, Roelof J.C. Kluin, Jeroen de Jong, Dorine C. Hintzen, Anniek Zaalberg, Martin Sjöström, Sylvan C. Baca, Yongsoo Kim, Liesbeth Hoekman, Umut Berkay Altintas, Tunc Morova, Chia-Chi Flora Huang, Joyce Sanders, Tesa M. Severson, Elise M. Bekers, Maartje Alkemade, Hilda de Barros, Karianne Schuurman, Nils Eickhoff, Suzan Stelloo, Marlous Hoogstraat, Simon Linder
Supplementary Data from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bc06dbadf0cd7246e380aada412ad4
https://doi.org/10.1158/2159-8290.22541195
https://doi.org/10.1158/2159-8290.22541195
Autor:
Patrick W.B. Derksen, Jos Jonkers, Paul J. van Diest, Elsken van der Wall, Ton Peeters, Petra van der Groep, Jeroen F. Vermeulen, Tanya M. Braumuller, Milou Tenhagen, Miranda van Amersfoort, Suzan Stelloo, Eva J. Vlug, Sjoerd Klarenbeek, Ron C.J. Schackmann
PDF - 346K, Loss of p120 and subsequent AJ inactivation does not induce autocrine survival pathways or increased EGF binding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0403ffdeade0f50227a0509e355ea3e6
https://doi.org/10.1158/0008-5472.22398096
https://doi.org/10.1158/0008-5472.22398096