Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Suzan S. Pezzoli"'
Autor:
James T. Patrie, Leon S. Farhy, Jianhua Liu, Bruce D. Gaylinn, Michael O. Thorner, Suzan S. Pezzoli, Ralf Nass
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 99:E1696-E1700
Ghrelin is a 28-amino acid peptide released from the stomach. Ghrelin is found in the circulation in two forms: acyl- and desacyl-ghrelin. Acyl- and desacyl-ghrelin concentrations increase at night, when cortisol concentrations are low. Acute ghrelin
Autor:
Suzan S. Pezzoli, Michael O. Thorner, Michael L. Johnson, Bruce D. Gaylinn, Leon S. Farhy, Jianhua Liu, Ralf Nass
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 99:602-608
Acyl-ghrelin is thought to have both orexigenic effects and to stimulate GH release. A possible cause of the anorexia of aging is an age-dependent decrease in circulating acyl-ghrelin levels.The purpose of the study was to compare acyl-ghrelin and GH
Autor:
Ralf Nass, H. Mario Geysen, Michael O. Thorner, Mary C. Oliveri, Paula P. Veldhuis, Michael L. Johnson, Suzan S. Pezzoli, Catherine E. Prudom, Leon S. Farhy, Jianhua Liu, Bruce D. Gaylinn
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:1988-1994
Context: The timing and frequency of GH secretory episodes is regulated by GHRH and somatostatin. This study provides evidence for amplification of these GH pulses by endogenous acyl-ghrelin. Design: Blood was sampled every 10 min for 26.5 h during a
Autor:
Ralf Nass, Mary C. Oliveri, Michael O. Thorner, Andrew D. Howard, Bruce D. Gaylinn, Catherine E. Prudom, H. Mario Geysen, Michael L. Johnson, David A. Gordon, Derrick R. Witcher, Paula P. Veldhuis, Suzan S. Pezzoli, Jianhua Liu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:1980-1987
Context: Ghrelin, an acylated peptide hormone secreted from the gut, regulates appetite and metabolism. Elucidating its pattern of secretion in the fed and fasted states is important in the face of the obesity epidemic. Objective: Our objective was t
Autor:
Michael O. Thorner, Stephen M Shalet, Ken H. Darzy, Helena Gleeson, Robert D Murray, Suzan S. Pezzoli
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:987-994
Context: In patients with severe radiation-induced GH deficiency, we previously demonstrated that pulsatile GH secretion and diurnal rhythm are maintained in the fed state, albeit with great attenuation of the pulse amplitude. However, it remained un
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 90:2794-2803
Dynamics of GH secretion in patients with GH deficiency due to radiation damage of the hypothalamic-pituitary (h-p) axis acquired in childhood has rarely been studied. Thus, we used a sensitive chemiluminescence GH assay to analyze 24-h GH profiles (
Autor:
Ralf Nass, Michael O. Thorner, Bruce D. Gaylinn, James T. Patrie, Mark L. Heiman, Suzan S. Pezzoli, Alexander Nikolayev, Leon S. Farhy, Jianhua Liu
Acyl-ghrelin is a 28-amino acid peptide released from the stomach. Ghrelin O-acyl transferase (GOAT) attaches an 8-carbon medium-chain fatty acid (MCFA) (octanoate) to serine 3 of ghrelin. This acylation is necessary for the activity of ghrelin. Anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8449247c050f9936342639e9b33dddf
https://europepmc.org/articles/PMC4283022/
https://europepmc.org/articles/PMC4283022/
Autor:
Judy Y. Weltman, Claude Bouchard, Michael O. Thorner, Jody L. Clasey, Mark L. Hartman, Arthur Weltman, Suzan S. Pezzoli, J Patrie
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 86:3845-3852
Numerous physiological factors modulate GH secretion, but these variables are not independent of one another. We studied 40 younger (20-29 yr.; 21 men and 19 women) and 62 older (57-80 yr.; 35 men and 27 women) adults to determine the contributions o
Autor:
Christian J. Strasburger, William F. Bennett, Michael O. Thorner, Martin Straume, Martin Bidlingmaier, Kenneth A. Zib, John C. Scarlett, Zida Wu, Suzan S. Pezzoli
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 84:2098-2103
B2036-PEG, a GH receptor (GH-R) antagonist, is an analog of GH that is PEG-modified to prolong its action. Nine mutations alter the binding properties of this molecule, preventing GH-R dimerization and GH action. A potential therapeutic role of B2036
Autor:
Michael O. Thorner, Raymond L. Hintz, Karen S. Pieper, Mark L. Hartman, Suzan S. Pezzoli, Ian Chapman, Emily H. Skiles
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:2836-2842
To determine the time course of recovery of GH release from insulin-like growth factor I (IGF-I) suppression, 11 healthy adults (18–29 yr) received, in randomized order, 4-h iv infusions of recombinant human IGF-I (rhIGF-I; 3 μg/kg·h) or saline (