Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Suzan H M, Rooijakkers"'
Autor:
Sjors P. A. van der Lans, Bart W. Bardoel, Maartje Ruyken, Carla J. C. de Haas, Stan Baijens, Remy M. Muts, Lisette M. Scheepmaker, Piet C. Aerts, Marije F. L. van ’t Wout, Johannes Preiner, Renoud J. Marijnissen, Janine Schuurman, Frank J. Beurskens, Priscilla F. Kerkman, Suzan H. M. Rooijakkers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Antibody-dependent complement activation plays a key role in the natural human immune response to infections. Currently, the understanding of which antibody-antigen combinations drive a potent complement response on bacteria is limited. Here
Externí odkaz:
https://doaj.org/article/a558f4acbc8844f0b4f524c388b29ef9
Autor:
Frerich M. Masson, Salvör Káradóttir, Sjors P. A. van der Lans, Dennis J. Doorduijn, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Bart W. Bardoel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant strains. The human complement system is an important part of our innate immune resp
Externí odkaz:
https://doaj.org/article/95f5d01250314a67b82131f20bab09f7
Autor:
Stian Foss, Siri A. Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz, Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg, Simone Mester, Malin Bern, Mitchell Evers, Diane B. Bratlie, Terje E. Michaelsen, Tilman Schlothauer, Devin Sok, Jayanta Bhattacharya, Jeanette Leusen, Thomas Valerius, Sanjay Ram, Suzan H. M. Rooijakkers, Inger Sandlie, Jan Terje Andersen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dos
Externí odkaz:
https://doaj.org/article/e2bf31ade1774fb9ab1a7bfa70490845
Autor:
Remy M. Muts, Maurits A. den Boer, Bart W. Bardoel, Piet C. Aerts, Carla J. C. de Haas, Albert J. R. Heck, Suzan H. M. Rooijakkers, Dani A. C. Heesterbeek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Antibodies play a key role in the immune defence against Gram-negative bacteria. After binding to bacterial surface antigens, IgG and IgM can activate the complement system and trigger formation of lytic membrane attack complex (MAC) pores.
Externí odkaz:
https://doaj.org/article/d8056fd0ab184a219de2c9b130cb1b1f
Autor:
Sjors P. A. van der Lans, Manon Janet-Maitre, Frerich M. Masson, Kimberly A. Walker, Dennis J. Doorduijn, Axel B. Janssen, Willem van Schaik, Ina Attrée, Suzan H. M. Rooijakkers, Bart W. Bardoel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Due to multi-drug resistance, physicians increasingly use the last-resort antibiotic colistin to treat infections with the Gram-negative bacterium Klebsiella pneumoniae. Unfortunately, K. pneumoniae can also develop colistin resistance. Inte
Externí odkaz:
https://doaj.org/article/4bc1a41af8354a7b8bc4d6d07f58d7bd
Autor:
Julia E. Egido, Catherine Toner-Bartelds, Ana Rita Costa, Stan J. J. Brouns, Suzan H. M. Rooijakkers, Bart W. Bardoel, Pieter-Jan Haas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Bacteriophages (phages) are viruses that specifically attack bacteria. Their use as therapeutics, which constitutes a promising alternative to antibiotics, heavily relies on selecting effective lytic phages against the pathogen of interest.
Externí odkaz:
https://doaj.org/article/69c7c55bb74c4019bbaf24c109984a49
Autor:
Elena Boero, Ronald D. Gorham, Emmet A. Francis, Jonathan Brand, Lay Heng Teng, Dennis J. Doorduijn, Maartje Ruyken, Remy M. Muts, Christian Lehmann, Admar Verschoor, Kok P. M. van Kessel, Volkmar Heinrich, Suzan H. M. Rooijakkers
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The complement system provides vital immune protection against infectious agents by labeling them with complement fragments that enhance phagocytosis by immune cells. Many details of complement-mediated phagocytosis remain elusive, partly be
Externí odkaz:
https://doaj.org/article/f3257d792e8348a29273436ad98c183c
Autor:
Anne Tvilum, Mikkel I. Johansen, Lærke N. Glud, Diana M. Ivarsen, Amanda B. Khamas, Sheiliza Carmali, Snehit Satish Mhatre, Ane B. Søgaard, Emma Faddy, Lisanne deVor, Suzan H. M. Rooijakkers, Lars Østergaard, Nis P. Jørgensen, Rikke L. Meyer, Alexander N. Zelikin
Publikováno v:
Advanced Science, Vol 10, Iss 23, Pp n/a-n/a (2023)
Abstract The treatment of implant‐associated bacterial infections and biofilms is an urgent medical need and a grand challenge because biofilms protect bacteria from the immune system and harbor antibiotic‐tolerant persister cells. This need is a
Externí odkaz:
https://doaj.org/article/c14c4fbfa5824745a650ffdb22b17f9d
Autor:
Julia E. Egido, Simon O. Dekker, Catherine Toner-Bartelds, Cédric Lood, Suzan H. M. Rooijakkers, Bart W. Bardoel, Pieter-Jan Haas
Publikováno v:
Viruses, Vol 15, Iss 11, p 2211 (2023)
Therapeutic bacteriophages (phages) are primarily chosen based on their in vitro bacteriolytic activity. Although anti-phage antibodies are known to inhibit phage infection, the influence of other immune system components is less well known. An impor
Externí odkaz:
https://doaj.org/article/ae71707406a24274beddaf20d409c971
Autor:
Manon Janet-Maitre, Stéphane Pont, Frerich M Masson, Serena Sleiman, Julian Trouillon, Mylène Robert-Genthon, Benoît Gallet, Chantal Dumestre-Perard, Sylvie Elsen, Christine Moriscot, Bart W Bardoel, Suzan H M Rooijakkers, François Cretin, Ina Attrée
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011023 (2023)
Pseudomonas aeruginosa, an opportunistic Gram-negative pathogen, is a leading cause of bacteremia with a high mortality rate. We recently reported that P. aeruginosa forms a persister-like sub-population of evaders in human plasma. Here, using a gain
Externí odkaz:
https://doaj.org/article/1a979eee135b46a9a780f929880fc55a