Výsledky vyhledávání - "Suzan El Anwar"

Akademický článek

The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX

Autor: Michael Kugler, Josef Holub, Jiří Brynda, Klára Pospíšilová, Suzan El Anwar, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, Milan Fábry, Bohumír Grüner, Pavlína Řezáčová

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1800-1810 (2020)

Human carbonic anhydrase IX (CA IX), a protein specifically expressed on the surface of solid tumour cells, represents a validated target both for anticancer therapy and diagnostics. We recently identified sulfonamide dicarbaboranes as promising inhi

Externí odkaz: https://doaj.org/article/4e570bd3c5e44b59a3ffde6f4d2e255b

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Focus on Chemistry of the 10-Dioxane-nido-7,8-dicarba-undecahydrido Undecaborate Zwitterion; Exceptionally Easy Abstraction of Hydrogen Bridge and Double-Action Pathways Observed in Ring Cleavage Reactions with OH− as Nucleophile

Autor: Mário Bakardjiev, Suzan El Anwar, Dmytro Bavol, Zdeňka Růžičková, Bohumír Grűner

Publikováno v: Molecules, Vol 25, Iss 4, p 814 (2020)

Ring cleavage of cyclic ether substituents attached to a boron cage via an oxonium oxygen atom are amongst the most versatile methods for conjoining boron closo-cages with organic functional groups. Here we focus on much less tackled chemistry of the

Externí odkaz: https://doaj.org/article/c97b5f4ef9534a6396c0053593bdcaba

Zobrazit plný text záznamu

Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials

Autor: Suzan El Anwar, Lucia Pazderová, Dmytro Bavol, Mário Bakardjiev, Zdeňka Růžičková, Ondřej Horáček, Lukáš Fojt, Radim Kučera, Bohumír Grűner

Publikováno v: Chemical Communications. 58:2572-2575

We report the difunctional modification of an anionic cobalta bis(dicarbollide)(1-) cluster with a B(8,8')-oxygen bridging unit that provides structural rigidity and an organic alkylazide substituent(s) on the carbon atoms of the metallacarborane cag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba735a36d58bb20a7d38a463d628ee82
https://doi.org/10.1039/d1cc06979a

Zobrazit plný text záznamu

Extraction characteristics and radiation stability of the CHALMEX process for separation of Am(III) and Eu(III) at different temperatures

Autor: Miriam Mindova, Petr Distler, Jan John, Karel Stamberg, Dmytro Bavol, Suzan El Anwar, Bohumir Gruner

Publikováno v: Separation and Purification Technology. 314:123534

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a67f3ba6ba359cebca7a429b921a97e
https://doi.org/10.1016/j.seppur.2023.123534

Zobrazit plný text záznamu

Tetrazole Ring Substitution at Carbon and Boron Sites of the Cobalt Bis(dicarbollide) Ion Available via Dipolar Cycloadditions

Autor: Dmytro Bavol, Suzan El Anwar, Lukáš Fojt, Zdeňka Růžičková, Bohumír Grüner

Publikováno v: Inorganic Chemistry. 59:17430-17442

Herein, we describe the synthesis of two families of compounds accessible from [3 + 2] cycloaddition reactions of known B8-substituted isonitrilium and new C1-alkylnitrile and C(1,1')-dialkylnitrile derivatives of the [(1,2-C2B9H11)2-3,3'-Co(III)]- i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4620f38f5f26444166b8601cdb3ff672
https://doi.org/10.1021/acs.inorgchem.0c02719

Zobrazit plný text záznamu

Direct Introduction of an Alkylsulfonamido Group on C‐sites of Isomeric Dicarba‐ closo ‐dodecaboranes: The Influence of Stereochemistry on Inhibitory Activity against the Cancer‐Associated Carbonic Anhydrase IX Isoenzyme

Autor: K. Pospisilova, Pavlína Řezáčová, Jan Nekvinda, Zdeňka Růžičková, Bohumír Grüner, Suzan El Anwar, Jiří Brynda, Josef Holub, M. Kugler

Publikováno v: Chemistry – A European Journal. 26:16541-16553

Carbonic anhydrase IX (CA IX), a tumor-associated metalloenzyme, represents a validated target for cancer therapy and diagnostics. Herein, we report the inhibition properties of isomeric families of sulfonamidopropyl-dicarba-closo-dodecaboranes group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908302526305d1f537475e2775022970
https://doi.org/10.1002/chem.202002809

Zobrazit plný text záznamu

Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds

Autor: Marian Hajduch, Bohumír Grüner, Jan Nekvinda, K. Pospisilova, Pavlína Řezáčová, Václav Šícha, Milan Fábry, Josef Holub, Viswanath Das, Jiří Brynda, Vlastimil Král, M. Kugler, Suzan El Anwar, Václav Kašička

Publikováno v: Chembiochem : a European journal of chemical biology. 22(18)

This review describes recent progress in the design and development of inhibitors of human carbonic anhydrase IX (CA IX) based on space-filling carborane and cobalt bis(dicarbollide) clusters. CA IX enzyme is known to play a crucial role in cancer ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f775f6a731302a55ab224f3696706f
https://pubmed.ncbi.nlm.nih.gov/33939874

Zobrazit plný text záznamu

The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX

Autor: Jiří Brynda, Pavlína Řezáčová, Suzan El Anwar, K. Pospisilova, Josef Holub, Milan Fábry, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, M. Kugler, Bohumír Grüner

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1800-1810 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449c33e7427effc015e0730de6c6a47c
https://pubmed.ncbi.nlm.nih.gov/32962427

Zobrazit plný text záznamu

Plný text ve formátu HTML

Vyhledávací nástroje:

Upřesnit hledání