Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Suzan Aschmies"'
Autor:
Brian F. Corbett, Jason C. You, Xiaohong Zhang, Mark S. Pyfer, Umberto Tosi, Daniel M. Iascone, Iraklis Petrof, Anupam Hazra, Chia-Hsuan Fu, Gabriel S. Stephens, Annie A. Ashok, Suzan Aschmies, Lijuan Zhao, Eric J. Nestler, Jeannie Chin
Publikováno v:
Cell Reports, Vol 20, Iss 2, Pp 344-355 (2017)
Alzheimer’s disease (AD) is characterized by cognitive decline and 5- to 10-fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear. We show that spontaneous seizures increase expression of
Externí odkaz:
https://doaj.org/article/cb35c2278b974e948a4663ea202778b5
Autor:
Daniel M. Iascone, Gabriel S. Stephens, Jeannie Chin, Chia-Hsuan Fu, Suzan Aschmies, Anupam Hazra, Iraklis Petrof, Annie A. Ashok, Brian F. Corbett, Lijuan Zhao, Mark S. Pyfer, Umberto Tosi, Jason C. You, Eric J. Nestler, Xiaohong Zhang
Publikováno v:
Cell Reports, Vol 20, Iss 2, Pp 344-355 (2017)
Alzheimer's disease (AD) is characterized by cognitive decline and 5- to 10-fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear. We show that spontaneous seizures increase expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0497e191008fc9b1eddaa78d07da9f7
https://doi.org/10.1016/j.celrep.2017.06.040
https://doi.org/10.1016/j.celrep.2017.06.040
Autor:
Ke Li, Jason C. You, Brian F. Corbett, Anupam Hazra, Jeannie Chin, Suzan Aschmies, Lijuan Zhao, Eric D. Marsh, Angelo C. Lepore
Publikováno v:
Neurobiology of Aging. 44:96-107
Alzheimer's disease is associated with cognitive decline and seizures. Growing evidence indicates that seizures contribute to cognitive deficits early in disease, but how they develop and impact cognition are unclear. To investigate potential mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72a98344657d09738b1bf88edf05739
https://doi.org/10.1016/j.neurobiolaging.2016.04.016
https://doi.org/10.1016/j.neurobiolaging.2016.04.016
Autor:
Shen Z, Tom A. Comery, David Smith, Brian J. Platt, Terrance H. Andree, Zhang Minsheng, Magid Abou-Gharbia, Sukoff-Rizzo Sj, Havran Lm, Chong Dc, Natasha Kagan, Zoë A. Hughes, Kelly Sullivan, Bach Ac rd, Boyd L. Harrison, Wayne E. Childers, Magda Asselin, Sharon Rosenzweig-Lipson, Claudine Pulicicchio, Steven M. Grauer, Marathias, George Theodore Grosu, Mark Day, Bicksler Jj, Chad E. Beyer, Adedayo Adedoyin, Christine Huselton, Sabb Al, Suzan Aschmies, Ronald L. Magolda, Warren D. Hirst, Kleintop T, Albert J. Robichaud
Publikováno v:
Journal of Medicinal Chemistry. 53:4066-4084
As part of an effort to identify 5-HT(1A) antagonists that did not possess typical arylalkylamine or keto/amido-alkyl aryl piperazine scaffolds, prototype compound 10a was identified from earlier work in a combined 5-HT(1A) antagonist/SSRI program. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8128f3b71923ae4c75a96a7c24e6d62e
https://doi.org/10.1021/jm1000908
https://doi.org/10.1021/jm1000908
Autor:
Cody Kelley, Marla Jean Williams, Kim Ji-In, Gregory J. Tawa, Katie Kubek, Joseph Raymond Stock, John W. Ellingboe, Thomas A. Comery, Suzan Aschmies, Warren D. Hirst, Brian J. Platt, William Ronald Solvibile, Xiaoping Ning, Jonathan Laird Gross, Albert J. Robichaud, Derek C. Cole
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1237-1240
Using a focused screen of biogenic amine compounds we identified a novel series of H3R antagonists. A preliminary SAR study led to reduction of MW while increasing binding affinity and potency. Optimization of the physical properties of the series le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9056c537f5642fa03e5ee54da0c7dc94
https://doi.org/10.1016/j.bmcl.2009.11.122
https://doi.org/10.1016/j.bmcl.2009.11.122
Autor:
Erik Wagner, Kevin Atchison, Julius Jefferson, Yolanda Kirksey, J. Steve Jacobsen, Helen K. Warwick, Peter J. Atkinson, Adrienne Parratt, David Riddell, Margaret M. Zaleska, Zhuting Li, Lin Xu, Peter H. Reinhart, Hua Zhou, Menelas N. Pangalos, J. Xu, Suzan Aschmies, Yun Hu
Publikováno v:
The Journal of Neuroscience. 28:11445-11453
Inheritance of the apoE4 allele (epsilon4) increases the risk of developing Alzheimer's disease; however, the mechanisms underlying this association remain elusive. Recent data suggest that inheritance of epsilon4 may lead to reduced apoE protein lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b63cdd1d3624dc219320bd1dd8ccc06
https://doi.org/10.1523/jneurosci.1972-08.2008
https://doi.org/10.1523/jneurosci.1972-08.2008
Autor:
Deborah L. Smith, Annmarie L. Saab, Heidi van der Lee, Terrance H. Andree, Wayne E. Childers, Zoe A. Hughes, Meiyi Zhang, Thomas A. Comery, Suzan Aschmies, John Kao, Michael G. Kelly, Lee E. Schechter, Warren D. Hirst, Sharon Rosenzweig-Lipson, Lee A. Dawson, Stacey J. Sukoff Rizzo, Mark Day, Cesario O. Tio, Steven M. Grauer, Kelly Sullivan, Irene B. Feingold, Boyd L. Harrison
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 325:134-145
5-Hydroxytryptamine (5-HT) 1A receptors play an important role in multiple cognitive processes, and compelling evidence suggests that 5-HT 1A antagonists can reverse cognitive impairment. We have examined the therapeutic potential of a potent ( K i =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2afe00ebb88c6f091a09af7c416f2132
https://doi.org/10.1124/jpet.107.133082
https://doi.org/10.1124/jpet.107.133082
Autor:
Karen L. Marquis, Suzan Aschmies, Hua Zhou, Robert Martone, Kevin Atchison, June Sonnenberg-Reines, Anthony Kreft, Menelas N. Pangalos, Thomas A. Comery, J. Steven Jacobsen, George Diamantidis, Xiaohai Gong
Publikováno v:
The Journal of Neuroscience. 25:8898-8902
Transgenic mice (Tg2576) overexpressing the Swedish mutation of the human amyloid precursor protein display biochemical, pathological, and behavioral markers consistent with many aspects of Alzheimer's disease, including impaired hippocampal function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b492d9ca4d6361b6a9a861cd42e865
https://doi.org/10.1523/jneurosci.2693-05.2005
https://doi.org/10.1523/jneurosci.2693-05.2005
Autor:
Jean Zhang, Peter H. Reinhart, Deborah L. Smith, Zoë A. Hughes, Geraldine Ruth Mcfarlane, Dianne Kowal, Mei-Yi Zhang, Angela Kramer, Michael M. Monaghan, Guoming Zhang, Al J. Robichaud, Suzan Aschmies, Menelas N. Pangalos, Simon Haydar, Thomas A. Comery, Christine Huselton
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::534d3f0041ad68ef732f8f4afc6dc82c
https://doi.org/10.1016/j.jalz.2010.05.1830
https://doi.org/10.1016/j.jalz.2010.05.1830
Autor:
Dianne Kowal, Ugo Zanelli, Riccardo Zanaletti, Laura Maccari, Maurizio Varrone, Albert J. Robichaud, Tim Lock, Michela Valacchi, Renza Roncarati, Carla Scali, Li Di, Georg C. Terstappen, Iolanda Micco, Flora Jow, Cristiana Castaldo, Arianna Nencini, Angela Kramer, Thomas A. Comery, John Dunlop, Suzan Aschmies, Hendrick Bothmann, Karen L. Marquis, Elisa Turlizzi, Chiara Ghiron, Giuseppe Cocconcelli, Salvatore La Rosa, Simon Haydar, Boyd L. Harrison, Joanna Quinn, Steven M. Grauer
Publikováno v:
Journal of medicinal chemistry. 53(11)
Alpha-7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment. We report a series of novel, potent small molecule agonists (4-18) of the alpha7 nAChR deriving from our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e335cbea368c3d67bdfa12e50c49f4
https://pubmed.ncbi.nlm.nih.gov/20465311
https://pubmed.ncbi.nlm.nih.gov/20465311